Iron Decreased: Causes & Reasons

Possible Causes for Iron Decreased

Although the transferrin level is increased, the serum iron level decreases; transferrin saturation decreases. [msdmanuals.com]

Absolute ID/IDA, i.e. the decrease of total body iron, is easily diagnosed based on decreased levels of serum ferritin and transferrin saturation. [ncbi.nlm.nih.gov]

Serum iron ↓ ↓ ↑ Normal or decreased (↓) Iron-binding capacity ↑ ↓ Normal Normal or decreased (↓) % Saturation of transferrin < 10 0 > 50 Normal or decreased (0–50) Serum [msdmanuals.com]

Anemia of Chronic Disease

[…] well obviously ** DECREASE ** what does that do to TIBC [aka transferrin] ?? well no circulating iron so ** DECREASE ** what does that do to stored iron [ferritin]?? [usmleforum.com]

Disordered iron metabolism as manifested by a low serum iron, decreased serum transferrin, decreased transferrin saturation, increased serum ferritin, increased reticuloendothelial [ncbi.nlm.nih.gov]

[…] smear Anemia of Chronic Disease: Iron Studies Serum iron is decreased Transferrin and TIBC decreased Saturation is decreased, although usually not as low as in iron deficiency [quizlet.com]

Erythropoietic Protoporphyria

Iron stores, assessed by serum ferritin (sFn), were decreased by two-thirds, but normal serum soluble transferrin receptor-1 and iron concentrations suggested that erythropoiesis [ncbi.nlm.nih.gov]

We report the case of a patient with erythropoietic protoporphyria and abnormal results of liver function tests in whom oral iron therapy led to a substantial decrease in [annals.org]

FECH deficiency in EPP appears to lead to a steady state in which decreased erythropoiesis is matched by reduced iron absorption and supply. [ncbi.nlm.nih.gov]

Paroxysmal Nocturnal Hemoglobinuria

After 12 months, eculizumab treatment resulted in significant decrease in the kidney iron load in both cases. [ncbi.nlm.nih.gov]

(pigment nephropathy), decreased renal perfusion from renal vein thrombosis, and tubular obstruction with pigment casts. [emedicine.medscape.com]

In both patients, abnormal iron load within the kidneys was demonstrated by magnetic resonance imaging, which correlated with diffuse and numerous hemosiderin inclusions within [ncbi.nlm.nih.gov]

Deferoxamine

In the 18 subjects completing 12 months of therapy, median liver iron concentration decreased by 31% from 17.4 mg/g (range 3.9-38.2mg/g) to 12.0mg/g (range 0.96-26.7 mg/g, [ncbi.nlm.nih.gov]

The patient had received gastrointestinal decontamination, deferoxamine (DFO) infusion, and hemodialysis (HD) resulting in a decrease in serum iron concentration from 2150 [ncbi.nlm.nih.gov]

Both L1 and DF could also prevent iron absorption. The new oral chelator deferasirox (DFX) increases iron excretion and decreases liver iron in TM and TI. [ncbi.nlm.nih.gov]

Polycythemia Vera

Polycythemia Vera Laboratory findings Elevated Hct – often >60% Increased WBCs and platelets Serum EPO levels are low Decreased iron stores (Ferritin) Increased Vitamin B12 [slideshare.net]

Most commonly, microcytosis is the result of decreased iron availability or an underlying inherited haemoglobinopathy such as thalassemia. [casereports.bmj.com]

The removal of blood from the body induces iron deficiency, thereby decreasing the haemoglobin / hematocrit level, and reducing the risk of blood clots. [en.wikipedia.org]

Chronic Kidney Insufficiency

It is usually caused by deficient erythropoietin production due to a reduction of functional renal mass (see Overview of Decreased Erythropoiesis ). [merckmanuals.com]

It is usually caused by deficient erythropoietin production due to a reduction of functional renal mass (see Overview of Decreased Erythropoiesis). [msdmanuals.com]

[…] erythropoietin production is the principal factor responsible for the anemia of CRF133; however, shortened red blood cell survival,134 associated iron and folate deficiencies [jamanetwork.com]

Celiac Disease

Serum IgA tTG levels typically decrease as patients maintain a gluten-free diet. [ncbi.nlm.nih.gov]

[…] bone density, unusual skin rashes, unexplained iron deficiency, and infertility. [ncbi.nlm.nih.gov]

Since the diagnosis of celiac disease is often delayed, there can be significant issues with iron deficiency anemia, osteoporosis because of decreased levels of calcium and [medicinenet.com]

Childhood Celiac Disease

[…] deficiency anemia Decreased appetite Delayed growth or puberty Thin bones or frequent fractures Failure to thrive Short stature By the time these symptoms have appeared, [beyondceliac.org]

[…] deficiency (by full blood count and iron studies), folic acid and vitamin B 12 deficiency and hypocalcaemia (low calcium levels, often due to decreased vitamin D levels). [en.wikipedia.org]

Include: Chronic diarrhea or constipation Abdominal pain Vomiting Bloating and gas Fatigue Damaged or discolored tooth enamel Skin rashes (known as dermatitis herpetiformis) Iron [beyondceliac.org]

Portal Cirrhosis

[…] estradiol degradation in liver) Direct toxic effect of alcohol or iron Nodular liver Irregular, hard surface on palpation Fibrosis, irregular regeneration Hepatocellular [pathophys.org]

[…] hair pattern Benign proliferation of glandular male breast tissue Elevated estradiol levels Hypogonadism Mainly in alcoholic cirrhosis and hemochromotasis Raised estradiol (decreased [pathophys.org]

Rheumatoid Arthritis

Increased risk Female sex Exposure to tobacco smoke Occupational dust (silica) Air pollution High sodium, red meat, and iron consumption Obesity Low vitamin D intake and levels [physio-pedia.com]

Decreased risk Fish and omega-3 fatty acid consumption Moderate alcohol intake Healthy diet Statin use Oral contraceptive use/hormone replacement Microbes and mucosal processes [physio-pedia.com]

Malabsorption Syndrome

Hemogram- Microcytic anemia- Iron Macrocytic anemia- Vit B12, folate 2. Prothrombin time- Vitamin K level decreased 3. Serum albumin- Decreased (protein loss) 4. [histopathology-india.net]

Muscle cramp from decreased vitamin D, calcium absorption. [en.wikipedia.org]

Low albumin can result from poor intake, decreased synthesis in cirrhosis, or protein wasting. [msdmanuals.com]

Myeloproliferative Disease

Patients benefit from routine phlebotomies which decrease iron overload on body organs. [lecturio.com]

[…] numbers of cells. lack of iron making RBC formation difficult spread of other diseases to the bone marrow Diseases of the different cell types Cell types and functions: White [news-medical.net]

[…] biological parameters routinely assessed which are affected in case of inflammation include blood cell counts (in particular leukocyte, neutrophil, and platelet counts), iron [hindawi.com]

Subtotal Gastrectomy

Also other factors include: the failure to reduce the ferric to the ferrous form of iron due to lack of acid the bypass of the major resorptive site (the duodenum) decreased [inmo.ie]

Iron deficiency anemia develops because removal of the stomach often leads to a marked decrease in the production of gastric acid. [my.clevelandclinic.org]

[…] liberation of food-bound iron due to lack of proteolysis rapid GI transit increased losses due to occult bleeding. [inmo.ie]

Renal Cell Carcinoma

The blood tests showed the biological signs of malabsorption with profound hypoalbuminemia (15.5 g/L, N > 37), decreased serum level of iron (0.52 mg/L, N > 7.5) and folic [onlinelibrary.wiley.com]

In a manner analogous to stabilization of HIF via decreased hydroxylation, hypoxia was shown to suppress JARID1A (KDM5A) activity, resulting in increased H3K4me3 levels [doi.org]

Like HIF prolyl hydroxylase (PHD, EGLN3), histone demethylases are members of the dioxygenase superfamily, which requires oxygen as well as iron and 2-oxoglutarate for activity [doi.org]

Inflammatory Bowel Disease Type 1

Iron‐deficient anaemia is the predominant type, with anaemia of chronic disease second. [doi.org]

Decreased dietary intake, as a result of decreased appetite and food aversion, is the major cause of undernutrition in paediatric IBD. [doi.org]

Glucagonoma

Serum iron is normal as was in our case. [ijdvl.com]

Anaemia may be due to glucagon excess, because prolonged treatment with a long acting glucagon preparation decreases erythropoiesis in animals. ESR is always elevated. [ijdvl.com]

Ulcerative Colitis

Dietary iron supplementation increases lipid peroxidation, decreases antioxidant vitamins, and enhances DSS induced colitis in rats. 37 Studies investigating the effects of [doi.org]

[…] oral iron administration in humans are lacking, as well as clinical studies assessing the effects of antioxidants in patients with UC. [doi.org]

Nephrotic Syndrome

Hepcidin regulates systemic iron homeostasis by causing the internalization and degradation of ferroportin, resulting in decreased iron absorption in the small intestine, [link.springer.com]

Eskelinen S, Haikonen M, Raisanen S (1983) Ferene-S as the chromogen for serum iron determinations. [link.springer.com]

Warshaw BL, Check IJ, Hymes LC, DiRusso SC (1984) Decreased serum transferrin concentration in children with the nephrotic syndrome: effect on lymphocyte proliferation and [link.springer.com]

Gaucher Disease

[…] gastrointestinal iron absorption and decreased mobilization of iron stores from hepatocytes and macrophages (Fleming & Bacon, 2005). [onlinelibrary.wiley.com]

Hepcidin is a peptide produced in hepatocytes which regulates iron absorption from the gut and release of iron from macrophages; increased levels of hepcidin result in decreased [onlinelibrary.wiley.com]

Glanzmann Thrombasthenia

[…] due to bleeding and/or concomitant iron deficiency. [emedicine.medscape.com]

[…] and folate supplementation Complications Uncontrolled bleeding Prognosis Good with supportive care Generally, bleeding decreases with age [step2.medbullets.com]

Adults are generally healthy as bleeding decreases with age. Also, mortality is rare. [symptoma.com]

Peptic Ulcer

[…] absorption of iron Malabsorption of fat Decreased acid secretions, decreased pancreatic secretions, increased upper GI mobility 25. [slideshare.net]

Lack of acid results in iron and mineral deficiencies and incomplete digestion of proteins. [articles.mercola.com]

[…] gastrectomies Early-30 minutes after meals Vertigo, tachycardia, syncope, sweating, pallor, palpatations Late – 90 min-3 hours after meals Anemia Rapid gastric empyting decreases [slideshare.net]

Idiopathic Pulmonary Hemosiderosis

MR finding include relatively decreased lung parenchymal signal intensity on T2-weighted images due to the paramagnetic effect of ferric iron. [advancedradteaching.com]

IPH commonly presents with the triad of dyspnea, hemoptysis, and iron deficiency anemia in both children and adults. Our patient did not exhibit hemoptysis. [omicsonline.org]

Lymphangioleiomyomatosis Autologous bone marrow transplant Pulmonary veno-occlusive disease Table 2: Causes of alveolar hemorrhage Interval improvement in bilateral lung aeration with decrease [omicsonline.org]

Mucolipidosis

Bone marrow examination yielded normocellular marrow with erythroid hyperplasia and decreased iron stores. Slit lamp examination showed bilateral corneal clouding. [jpgmonline.com]

Malaria

[…] production of erythrocytes, including cell lysis as parasites replicate and exit erythrocytes, splenic removal and autoimmune lysis of immune-marked erythrocytes, poor iron [ncbi.nlm.nih.gov]

[…] showed lower initial brain volume or a downtrend over time.[33] Severe malarial anemia stems from TNF-alpha-mediated mechanisms involving both increased destruction and decreased [ncbi.nlm.nih.gov]

[…] incorporation into new heme molecules, and bone marrow suppression during severe infection leading to decreased production.[1][4] Blackwater fever is severe anemia with hemoglobinuria [ncbi.nlm.nih.gov]

Microangiopathic Hemolytic Anemia

[…] number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the most common type is iron [medical-dictionary.thefreedictionary.com]

[…] anemia ( Fanconi's hypoplastic anemia ) Fanconi's syndrome (def. 1). hypochromic anemia anemia in which the decrease in hemoglobin is proportionately much greater than the decrease [medical-dictionary.thefreedictionary.com]

Whipple Disease

As the gastrointestinal tract lesion in Whipple's disease is primarily in the upper small intestine, iron and folate concentrations may be decreased, though vitamin B-12 concentrations [pmj.bmj.com]

Cranial nerve examination was normal while motor examination revealed decreased muscle bulk but normal power. Sensory examination was normal. [caribbean.scielo.org]

Investigations revealed iron deficiency anaemia, normal electrolytes and hypoalbuminaemia. HIV and HTLV-1 tests were negative. Colonoscopy with biopsy was normal. [caribbean.scielo.org]

Kwashiorkor

CONCLUSIONS: 'Free' circulating iron may contribute to the oedema of kwashiorkor, and its sequestration could hasten recovery and decrease morbidity and mortality. [ncbi.nlm.nih.gov]

CONCLUSIONS ‘Free’ circulating iron may contribute to the oedema of kwashiorkor, and its sequestration could hasten recovery and decrease morbidity and mortality. kwashiorkor [adc.bmj.com]

Moderate anaemia (haemaglobin 80–100 g/L) is seen in most cases, but plasma free iron is raised. [ncbi.nlm.nih.gov]

Hookworm Infection

Patients with heavy hookworm infection showed a marked decrease of the serum B 12 as compared with normal subjects. [bloodjournal.org]

Serum ferritin and protoporphyrin levels are decreased. [symptoma.com]

Infection leads to blood loss and a decrease in the amount of iron, and this causes anemia (i.e., because of a lack of iron, the blood cannot carry oxygen efficiently). [doi.org]

Scurvy

In addition to these symptoms, deficiency of ascorbic acid may lead to an hypochromic microcytic anemia because of decreased absorption of iron, bleeding, and dietary deficiencies [hindawi.com]

[…] hemoglobin and hematocrit and low serum iron (8.8 gdL and 26%) Chest radiograph demonstrated mild diffuse osteoporosis Hypertrophic and bleeding gingiva MRI of knees revealed [physio-pedia.com]

Iron deficiency anemia can also occur due to increased bleeding and decreased nonheme iron absorption secondary to low vitamin C intake [ 6, 11 ]. [web.archive.org]