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834 Possible Causes for Iron Deficiency, Jaundice, Splenomegaly

  • Pernicious Anemia

    She was readmitted with jaundice and macrocytic anemia.[ncbi.nlm.nih.gov] Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Biology of Iron-Deficiency Anemia An iron deficiency can also disrupt hemoglobin function, causing iron-deficiency anemia.[livestrong.com]

  • Erythropoietic Protoporphyria

    A 21-year-old Japanese man was admitted to our hospital because of severe abdominal pain and jaundice.[ncbi.nlm.nih.gov] As hepatic complications worsen the patient will develop splenomegaly, leading to entrapment and hemolysis of erythrocytes.[clinicaladvisor.com] These disorders are often associated with iron deficiency anaemia (IDA).[ncbi.nlm.nih.gov]

  • Thalassemia

    Clinical description Patients present with moderate to severe anemia, jaundice and splenomegaly.[orpha.net] Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Red cell distribution width in iron deficiency anemia and β-thalassemia minor [letter]. Am J Clin Pathol. 2008 ; 130 : 313 – 314. 5..[doi.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] PNH through chronic intravascular hemolysis induces an urinary iron loss. This is the only cause of hemolytic anemia inducing iron deficiency.[ncbi.nlm.nih.gov]

  • Hemochromatosis

    Here we report the case of a 16-year-old Chinese boy, who was admitted with hepatalgia, jaundice, hyperpigmentation, and splenomegaly to our hospital.[ncbi.nlm.nih.gov] Regression on SF revealed significant associations: TS; male sex; age; GGT; transfusion units (positive); and splenomegaly (negative) (p 0.0001, 0.0016, 0.0281, 0.0025, 0.0001[ncbi.nlm.nih.gov] deficiency anemia - ferritin Brittenham GM.[medlineplus.gov]

  • Portal Hypertension

    […] and left abdominal pain or fullness as a result Because portal hypertension is commonly caused by cirrhosis, liver failure symptoms can also indicate portal hypertension: Jaundice[radiology.ucla.edu] We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] COMPLICATIONS • Variceal bleeding • Congestive gastropathy • Hypersplenism • Ascites • Iron deficiency anaemia • Renal failure • Hepatic encephalopathy 24.[slideshare.net]

  • Alpha Thalassemia

    BACKGROUND: Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice[ncbi.nlm.nih.gov] Serum ferritin level A normal serum ferritin level helps to exclude the diagnosis of iron deficiency anemia as iron stores will be low in iron deficiency anemia.[medicaljoyworks.com] Patients have variable microcytic hypochromic hemolytic anemia, splenomegaly (50 to 80%) and less commonly hepatomegaly (50%), mild jaundice (20-40%), and mild-to-moderate[orpha.net]

  • Hereditary Spherocytosis

    This case also highlights the fact that physicians should consider concomitant hemolytic disease in patients in whom jaundice and infections that rarely cause jaundice coexist[ncbi.nlm.nih.gov] Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Describing 6 typical cases, we demonstrate that occasional normal percentages of hyperchromic red blood cells occurring during phases of anemia and/or iron deficiency are[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Children develop life-threatening anemia, have failure to thrive, and may develop jaundice.[secure.ssa.gov] Splenomegaly, episodes of jaundice and roentgenologic evidence of bone involvement were prominent features.[jamanetwork.com] As in mild alpha thalassemia, physicians often mistake the small red blood cells of the person with beta thalassemia minor as a sign of iron-deficiency anemia and incorrectly[unicosandiego.org]

  • Pyruvate Kinase Deficiency

    Pyruvate kinase deficiency may cause pregnancy-associated jaundice.[ncbi.nlm.nih.gov] Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency.[ncbi.nlm.nih.gov] Iron overload has been reported with pyruvate kinase deficiency.[ncbi.nlm.nih.gov]

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