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686 Possible Causes for Iron Deficiency, Leg Swelling, Peripheral Neuropathy

  • Hemophilia

    He suffered from peripheral neuropathy and had a total knee replacement. He lived and worked in Houston, TX.[hemophiliafed.org]

  • Hemophilia B

    Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene. According to the US Centers[…][hemophilia.org]

  • Celiac Disease

    A profoundly emaciated 43-year-old female presented with profuse diarrhoea, shortness of breath, left leg swelling with ulceration and immobility (Body Mass Index (BMI)   [ncbi.nlm.nih.gov] OBJECTIVE: To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease.[ncbi.nlm.nih.gov] […] manifestations, thus suggesting that CD should always be considered in the differential diagnosis of peripheral neuropathy in children.[ncbi.nlm.nih.gov]

  • Restless Legs Syndrome

    They can cause pain, burning discomfort, aching and itching as well as generalised aching, heaviness or swelling in the legs, cramps at night and restless leg syndrome.[healthdirect.gov.au] The main objective of the study was to find occurrence of RLS in patients with iron deficiency anemia and compare it to non-anemic healthy people.[ncbi.nlm.nih.gov] Parkinsonism [adjusted odds' ratio (adj-OR) 7.4 (95% CI: 5.3-10.4)], peripheral neuropathy [adj-OR 3.7 (95% CI: 3.3-4.1)], subjective cognitive impairment (SCI) [adj-OR 3.1[ncbi.nlm.nih.gov]

  • Cecal Adenocarcinoma

    We report a case of a perforated caecal adenocarcinoma presenting with right leg erythema, pain and swelling in the presence of a right lower lobe lung opacity.[casereports.bmj.com] A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia.[ncbi.nlm.nih.gov] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Multiple Myeloma

    swelling What are risk factors for multiple myeloma?[medicinenet.com] In each case, anemia was due to causes other than plasma-cell proliferation, such as iron deficiency, renal insufficiency, or myelodysplasia.[nejm.org] The mechanism of the development of the peripheral neuropathy is poorly understood.[ncbi.nlm.nih.gov]

  • Acute Intermittent Porphyria

    Pain may also occur in the neck, lower back, buttocks, or arms and legs.[rarediseases.org] Other conditions (iron deficiency) that affect heme synthesis do not produce neuropathic syndromes (6,7,12,13).[cyberleninka.org] Both had a very poor quality of life as a result of years of frequent acute porphyria symptoms, chronic peripheral neuropathy and renal failure requiring dialysis.[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    She had significant worsening of leg swelling after standing for short periods of time.[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov] Initial studies revealed iron-deficiency anemia and blood in the stool.[endoatlas.com]

  • Erythropoietic Protoporphyria

    These disorders are often associated with iron deficiency anaemia (IDA).[ncbi.nlm.nih.gov] Symptomatically, acute porphyrias primarily present with nervous system involvement, often with severe abdominal pain , vomiting , peripheral neuropathy and mental disturbances[house.wikia.com] ., whether it is the result of an absolute iron deficiency or the anemia of chronic disease (ACD).[ncbi.nlm.nih.gov]

  • Acute Hepatic Porphyria

    Pain may also occur in the neck, lower back, buttocks, or arms and legs.[rarediseases.org] Inducing iron deficiency improves erythropoiesis and photo sensivity in congenital erythropoietic porphyria. Blood. 2015;126(2):257–261.[medcraveonline.com] Features of Textbook of Peripheral Neuropathy Include : ̈ Practical yet comprehensiveóan accessible ìgo-toî reference for clinicians ̈ Covers all clinically relevant peripheral[books.google.com]

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