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855 Possible Causes for Iron Deficiency, Splenomegaly

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Biology of Iron-Deficiency Anemia An iron deficiency can also disrupt hemoglobin function, causing iron-deficiency anemia.[livestrong.com] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Gastrointestinal Hemorrhage

    This is often due to pre-existing liver disease and splenomegaly.[geekymedics.com] Chronic or occult gastrointestinal bleeding is not apparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia.[ncbi.nlm.nih.gov] Other signs to look for are ascites and erythema (chronic liver disease) and splenomegaly and dilated abdominal wall veins (portal hypertension).[uspharmacist.com]

  • Erythropoietic Protoporphyria

    As hepatic complications worsen the patient will develop splenomegaly, leading to entrapment and hemolysis of erythrocytes.[clinicaladvisor.com] These disorders are often associated with iron deficiency anaemia (IDA).[ncbi.nlm.nih.gov] Health problems associated with erythropoietic porphyrias include a low number of red blood cells ( anemia ) and enlargement of the spleen (splenomegaly).[ghr.nlm.nih.gov]

  • Thalassemia

    Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] Red cell distribution width in iron deficiency anemia and β-thalassemia minor [letter]. Am J Clin Pathol. 2008 ; 130 : 313 – 314. 5..[doi.org] KEYWORDS: Anemia; genotype-phenotype; hemolysis; relationship; splenomegaly; β-thalassemia intermedia (β-TI)[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] PNH through chronic intravascular hemolysis induces an urinary iron loss. This is the only cause of hemolytic anemia inducing iron deficiency.[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov]

  • Essential Thrombocythemia

    […] essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly[ncbi.nlm.nih.gov] -41 Nakasuji, Takasago 676-0812, Japan. shinim95@mbox.kyoto-inet.or.jp Abstract When elderly patients present with persistent thrombocytosis, myeloproliferative disease, iron-deficiency[ncbi.nlm.nih.gov] We present the case of a 41-year-old woman with thrombocytosis and mild splenomegaly. Clinical suspicion was of chronic myeloproliferative neoplasia (CMN).[ncbi.nlm.nih.gov]

  • Portal Hypertension

    We performed LS in 83 patients with massive splenomegaly ( 30 cm) secondary to portal hypertension and liver cirrhosis.[ncbi.nlm.nih.gov] COMPLICATIONS • Variceal bleeding • Congestive gastropathy • Hypersplenism • Ascites • Iron deficiency anaemia • Renal failure • Hepatic encephalopathy 24.[slideshare.net] […] in the body (hemochromatosis) Cystic fibrosis Copper accumulated in the liver (Wilson's disease) Poorly formed bile ducts (biliary atresia) Alpha-1 antitrypsin deficiency[mayoclinic.org]

  • Mucolipidosis

    […] conditions 'stand alone', 'walk without support' and 'speak single words' were impaired; however, the frequency of 'heart murmur', 'inguinal hernia' and 'hepatomegaly and/or splenomegaly[ncbi.nlm.nih.gov] For instance, anemia is treated by iron supplements. Some of the movement deficiencies may be corrected with orthopedic intervention.[en.wikipedia.org] Disturbance - see also Disease Fabry's disease (angiokeratoma corporis diffusum) 272.7 Gaucher's disease (adult) (cerebroside lipidosis) (infantile) 272.7 hepatomegaly 272.7 splenomegaly[icd9data.com]

  • Alpha Thalassemia

    BACKGROUND: Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice, splenomegaly[ncbi.nlm.nih.gov] It is 13 in patients affected by iron deficiency anemia and 13 in patients that have inherited thalassemia.[symptoma.com] Three deletions: Hb H Disease Patients with three alpha-globin deletions display a symptomatic microcytic anemia with moderate extravascular hemolysis that may yield splenomegaly[pathwaymedicine.org]

  • Schistosomiasis

    Initial investigation showed signs of liver fibrosis, portal hypertension and splenomegaly.[ncbi.nlm.nih.gov] deficiency as a result of blood loss/destruction, and general inflammation (Friedman, Kanzaria, and McGarvey 2005).[spring-nutrition.org] The hepatosplenic form of the disease is characterized by periportal hepatic fibrosis, pre-sinusoidal portal hypertension and splenomegaly.[ncbi.nlm.nih.gov]

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