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45 Possible Causes for Iron Deficiency Anemia, Melena, Prothrombin Time Increased

  • Factor VII Deficiency

    At a Glance Acquired factor VII deficiency may be suspected in a patient who has an increased prothrombin time (PT) with a normal activated partial thromboplastin time (aPTT[clinicaladvisor.com] Other signs of bleeding include hematuria, melena, or hematochezia. Physical exam Bruising may be apparent on examination.[symptoma.com] However, obstetricians should consider this diagnosis whenever the prothrombin time is prolonged while the activated partial thromboplastin time is normal.[ncbi.nlm.nih.gov]

  • Duodenal Ulcer

    Prothrombin time more than 1.2 times control, 4. Altered mental status, 5.[slideshare.net] A 48-year-old woman was admitted to our hospital due to melena. An upper endoscopy revealed a small ulcer with oozing adjacent minor papilla.[ncbi.nlm.nih.gov] Seventy-nine percent of recurrences are asymptomatic with cirrhotic patients. 17 Patients of cirrhosis of liver can present with hematemesis, malena and iron deficiency anemia[pjmhsonline.com]

  • Essential Thrombocythemia

    Other laboratory findings in ET include: Normal or slightly increased thrombopoeitin Usually normal prothrombin time (PT) and activated partial thromboplastin time (aPTT)[labce.com] […] list of signs and symptoms mentioned in various sources for Hemorrhagic thrombocythemia includes the 18 symptoms listed below: * Spontaneous bleeding * Coughing up blood * Melena[checkorphan.org] -41 Nakasuji, Takasago 676-0812, Japan. [email protected] Abstract When elderly patients present with persistent thrombocytosis, myeloproliferative disease, iron-deficiency[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    time Hypoalbuminemia Liver enzyme levels Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels elevated, usually 300 U/L; AST/ALT ratio 2:1 Hematologic[clevelandclinicmeded.com] Hematemesis and melena: Mallory-Weiss syndrome. Tokai J Exp Clin Med. 1980 Jul;5(3):289-92.[bestpractice.bmj.com] Alcoholic gastritis often “oozes” blood, which can lead to iron-deficiency anemia, but it can also cause sudden and dramatic blood loss, especially if the condition progresses[livestrong.com]

  • Hemophilia

    A person with hemophilia would display an increased blood clotting time in their results.[physio-pedia.com] […] pain, stiffness, and refusal to use joint (children) CNS: Headache, stiff neck, vomiting, lethargy, irritability, and spinal cord syndromes Gastrointestinal: Hematemesis, melena[emedicine.com] Signs and symptoms of GI involvement include: • Fever • Abdominal distention and pain • Melena (bloody stool) • Hip flexion contracture (iliopsoas muscle spasm due to retroperitoneal[physio-pedia.com]

  • Acute Iron Intoxication

    […] occur without preceding GI toxicity following iron ingestion) Local effects: corrosive injury to the gastrointestinal mucosa resulting in vomiting, diarrhoea, hemetemesis, melena[lifeinthefastlane.com] When prothrombin time and bilirubin began to increase, she was transferred to our facility in case liver transplantation became necessary.[thefreelibrary.com] Its depletion can lead to iron deficiency anemia. Usually the required amount of iron is available from the food that we eat.[tandurust.com]

  • Vitamin K Deficiency

    Median PIVKA-II and Owren prothrombin time (PT-INR) were increased on the morning day 1 postoperatively compared to before surgery, whereas Quick end-stage prothrombin time[ncbi.nlm.nih.gov] CASE: A young woman with a diagnosis of Crohn disease presented at 22 weeks' gestation with diarrhea and melena for 3 weeks. Dietary and medicinal therapies were begun.[ncbi.nlm.nih.gov] Laboratory analyses showed the presence of iron-deficiency anemia, mild hypoalbuminemia, and considerably prolonged prothrombin time and activated thromboplastin time.[ncbi.nlm.nih.gov]

  • Alcoholic Gastritis

    Often the blood acetaminophen level is low and unmeasurable and the diagnosis is based largely on the aspartate amino-transferase level, prothrombin time, and a history. 2[nurseslearning.com] It can occasionally be severe enough to cause gastrointestinal bleeding with melena or hematemesis (see above).[gastrointestinalatlas.com] Alcoholic gastritis often “oozes” blood, which can lead to iron-deficiency anemia, but it can also cause sudden and dramatic blood loss, especially if the condition progresses[livestrong.com]

  • Scurvy

    Individuals on anticoagulants should limit their vitamin C intake to 1 gram/day and have their prothrombin time monitored by the clinician following their anticoagulant therapy[web.archive.org] Rarely, hematuria, hematochezia, and melena are noted.[web.archive.org] Although non-specific, iron-deficiency anemia is a characteristic finding, partly secondary to reduced iron absorption in the setting of vitamin C deficiency, even in the[clinicaladvisor.com]

  • Disseminated Intravascular Coagulation

    […] old man was found unconscious; on admission found to have disseminated intravascular coagulation with concern of upper gastrointestinal bleed after he was found to have melena[ncbi.nlm.nih.gov] Moderate increase Strong increase Fibrinogen (g/L) 1 Prothrombin time (increase in seconds) 3-6 6 FEU fibrinogen equivalent units Toh, ISTH, 2007 Laboratory Testing D-dimer[arupconsult.com] Witmer , Hematologic Manifestations of Systemic Disease (Including Iron Deficiency, Anemia of Inflammation and DIC) , Pediatric Clinics of North America , 60 , 6 , (1337)[doi.org]

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