Non-HFE gene mutations may predispose HH patients to iron deposition in the brain. [ncbi.nlm.nih.gov]

When the 2 groups were compared for iron overload, iron deposition in the liver was significantly higher in group B (p 0.046). [ncbi.nlm.nih.gov]

Testicular atrophy, sometimes caused by excessive iron deposition in the testes, is a risk factor for testicular cancer. [ncbi.nlm.nih.gov]

[…] spheroids, and iron deposition in a typical distribution. [jnnp.bmj.com]

Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI. [ncbi.nlm.nih.gov]

Pathologically, there is iron deposition in the basal ganglia, with destruction of basal ganglia output neurons. [ncbi.nlm.nih.gov]

Pathology Some causes include: frequent transfusion mainly depositional siderosis in RES if 40 units transfused: then may cause hemochromatosis (non-RES iron deposition) high [radiopaedia.org]

Organs may be damaged by the iron deposits. The extent of the damage depends on how much iron is deposited in the organs. [merckmanuals.com]

(non-RES iron deposition) bantu siderosis : rare cause in Africa due to iron-laden locally brewed beer See also siderosis splenic siderosis hepatic siderosis pulmonary hemosiderosis [radiopaedia.org]

Iron deposition is prominent both in macrophages and in hepatic parenchymal cells. [ncbi.nlm.nih.gov]

Heavy iron deposition in both hepatocytes and Kupffer cells was reported in individuals with Y64N FPN, 13 whereas iron deposition is predominantly in hepatocytes in C326Y [doi.org]

• This is a pathological state in which total body stores or iron are increased. • This can often result in organ dysfunction as a result of iron deposition List causes of [quizlet.com]

Evaluation of the cochlear nucleus revealed iron deposits within glial cells and larger cells, probably macrophages, near the CSF surface. [ncbi.nlm.nih.gov]

First described more than 100 years ago, only recently SS has been divided into two distinct entities, according to the distribution of iron deposition in the CNS: cortical [ncbi.nlm.nih.gov]

The diagnosis may be confirmed by computed tomography, which shows degeneration of the cerebellar vermis, and by magnetic resonance imaging, demonstrating iron deposits on [ncbi.nlm.nih.gov]

Our histochemical studies support the concept that increased iron deposition in the putamen is responsible for this MRI picture. [ncbi.nlm.nih.gov]

These findings suggest that increased iron deposition may be related to pigment formation in the putamen of SND. [ncbi.nlm.nih.gov]

SND may be associated with increased iron deposition in the putamen which can be detected with magnetic resonance imaging. [ncbi.nlm.nih.gov]

In another case with no cytogenetic abnormality, repeated iron staining showed that 31% to 40% of CFU-E and 25% to 54% of BFU-E had erythroblasts with heavy iron deposits. [ncbi.nlm.nih.gov]

The red cell precursors from all patients showed the presence of electron-dense material in the mitochondria, representing most probably iron deposits. [ncbi.nlm.nih.gov]

[…] have increased bone marrow iron stores. 7 Increased iron deposits in patients with RARS have been described as finely granular or rarely coarsely granular. 8 In hemosiderosis [nature.com]

Haplotype analysis revealed that the p.Ala63Pro mutations have a common origin, but MRI scans showed no brain iron deposition in the Malian SPG43 subjects. [experts.umich.edu]

deposits within mitochondria. [ncbi.nlm.nih.gov]

deposits in mitochondria of late erythroblasts and reticulocytes, and a high platelet count. [ncbi.nlm.nih.gov]

A defining feature is excessive iron deposition within mitochondria of developing red cells, the consequences of which are an increase in cellular free radicals production [ncbi.nlm.nih.gov]

The excess iron deposits as non-ferritin iron in the mitochondria that surround the nuclei of proerythroblasts (immature red blood cells). [themedicalbiochemistrypage.org]

Erythroid precursor shows iron deposits in mitochondrial cristae Differential diagnosis Chloramphenicol or TB drug (isoniazid) exposure, copper deficiency, alcohol or chronic [pathologyoutlines.com]

Immunodeficiency. [89] Bone marrow biopsy pathology: Erythroid precursors featuring perinuclear mitochondrial iron deposits (“ringed sideroblasts”). [89] Search Keywords: [autoinflammatory-search.org]