Non-HFE gene mutations may predispose HH patients to iron deposition in the brain.
[ncbi.nlm.nih.gov]
When the 2 groups were compared for iron overload, iron deposition in the liver was significantly higher in group B (p=0.046).
[ncbi.nlm.nih.gov]
Testicular atrophy, sometimes caused by excessive iron deposition in the testes, is a risk factor for testicular cancer.
[ncbi.nlm.nih.gov]
[…] spheroids, and iron deposition in a typical distribution.
[jnnp.bmj.com]
Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI.
[ncbi.nlm.nih.gov]
Reflects areas of iron deposition, mainly in the globi pallidi, substantia nigra, and red nuclei.
[radiopaedia.org]
Pathology Some causes include: frequent transfusion mainly depositional siderosis in RES if >40 units transfused: then may cause hemochromatosis (non-RES iron deposition)
[radiopaedia.org]
Organs may be damaged by the iron deposits. The extent of the damage depends on how much iron is deposited in the organs.
[merckmanuals.com]
(non-RES iron deposition) bantu siderosis : rare cause in Africa due to iron-laden locally brewed beer See also siderosis splenic siderosis hepatic siderosis pulmonary hemosiderosis
[radiopaedia.org]
Iron deposition is prominent both in macrophages and in hepatic parenchymal cells.
[ncbi.nlm.nih.gov]
• This is a pathological state in which total body stores or iron are increased. • This can often result in organ dysfunction as a result of iron deposition List causes of
[quizlet.com]
Hemosiderosis is focal deposition of iron that does not cause tissue damage.
[msdmanuals.com]
The excess iron deposits as non-ferritin iron in the mitochondria that surround the nuclei of proerythroblasts (immature red blood cells).
[themedicalbiochemistrypage.org]
Erythroid precursor shows iron deposits in mitochondrial cristae Differential diagnosis Chloramphenicol or TB drug (isoniazid) exposure, copper deficiency, alcohol or chronic
[pathologyoutlines.com]
Immunodeficiency. [89] Bone marrow biopsy pathology: Erythroid precursors featuring perinuclear mitochondrial iron deposits (“ringed sideroblasts”). [89] Search Keywords:
[autoinflammatory-search.org]
In another case with no cytogenetic abnormality, repeated iron staining showed that 31% to 40% of CFU-E and 25% to 54% of BFU-E had erythroblasts with heavy iron deposits.
[ncbi.nlm.nih.gov]
The red cell precursors from all patients showed the presence of electron-dense material in the mitochondria, representing most probably iron deposits.
[ncbi.nlm.nih.gov]
[…] have increased bone marrow iron stores. 7 Increased iron deposits in patients with RARS have been described as finely granular or rarely coarsely granular. 8 In hemosiderosis
[nature.com]
deposits within mitochondria.
[ncbi.nlm.nih.gov]
deposits in mitochondria of late erythroblasts and reticulocytes, and a high platelet count.
[ncbi.nlm.nih.gov]
A defining feature is excessive iron deposition within mitochondria of developing red cells, the consequences of which are an increase in cellular free radicals production
[ncbi.nlm.nih.gov]
Haplotype analysis revealed that the p.Ala63Pro mutations have a common origin, but MRI scans showed no brain iron deposition in the Malian SPG43 subjects.
[experts.umich.edu]
[…] neurodegenerative disorders characterised by basal ganglia iron deposition.
[spatax.wordpress.com]
[…] genetically heterogenous paediatric neurodegenerative disorders characterised by basal ganglia iron deposition.
[spatax.wordpress.com]
Evaluation of the cochlear nucleus revealed iron deposits within glial cells and larger cells, probably macrophages, near the CSF surface.
[ncbi.nlm.nih.gov]
First described more than 100 years ago, only recently SS has been divided into two distinct entities, according to the distribution of iron deposition in the CNS: cortical
[ncbi.nlm.nih.gov]
The diagnosis may be confirmed by computed tomography, which shows degeneration of the cerebellar vermis, and by magnetic resonance imaging, demonstrating iron deposits on
[ncbi.nlm.nih.gov]
Perls' stain (for iron deposits) revealed Michaelis–Gutmann bodies in cytoplasm of histiocytes, which are pathognomic of malakoplakia [Figure 2] a.
[ijpmonline.org]
[…] of iron and calcium (known as Michaelis-Gutmann bodies) Treatment Antibiotics that concentrate in macrophages (quinolones or trimethoprim-sulfamethoxazole), antibiotics directed
[pathologyoutlines.com]
From the above results, M-G bodies can be assumed to be gradually formed by deposit of calcium, iron and others to the content of the phagolysosome containg bacteria products
[jstage.jst.go.jp]
[…] are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.
[malacards.org]
Erythroid precursor shows iron deposits in mitochondrial cristae Differential diagnosis Chloramphenicol or TB drug (isoniazid) exposure, copper deficiency, alcohol or chronic
[pathologyoutlines.com]
Immunodeficiency. [89] Bone marrow biopsy pathology: Erythroid precursors featuring perinuclear mitochondrial iron deposits (“ringed sideroblasts”). [89] Search Keywords:
[autoinflammatory-search.org]
Erythroid precursor shows iron deposits in mitochondrial cristae Differential diagnosis Chloramphenicol or TB drug (isoniazid) exposure, copper deficiency, alcohol or chronic
[pathologyoutlines.com]
deposits around the nucleus.
[amboss.com]
Mishandling of iron by mitochondria could be the basis of the iron deposits.
[sickle.bwh.harvard.edu]
Such hypointensity is attributable to iron accumulation Iron deposition with age.
[slideshare.net]
[…] suggest a molecular link between iron deposition and alpha-synuclein accumulation.
[ncbi.nlm.nih.gov]
Exact pathologic mechanism of iron deposition in NBIA remains unknown.
[ncbi.nlm.nih.gov]
As the disease progressed, a repeat brain MRI showed iron deposition in the basal ganglia at nine years of age.
[ncbi.nlm.nih.gov]
Neurodegeneration with brain iron accumulation (NBIA) refers to an inherited heterogeneous group of disorders pathologically characterized by focal brain iron deposition.
[ncbi.nlm.nih.gov]
[…] degeneration of the central nervous system and high basal ganglia iron deposition.
[ncbi.nlm.nih.gov]
Iron deposition in the caudate head and cavitation in the lateral globus pallidus correlated with UDRS score (p < 0.001).
[ncbi.nlm.nih.gov]
Now that the molecular basis of the condition is known, therapeutic interventions to reduce or reverse brain iron deposition are being evaluated.
[ncbi.nlm.nih.gov]
Brain magnetic resonance imaging demonstrates iron deposition in the basal ganglia and cavitation.
[eurekaselect.com]
Persistent elevation of NSE and iron deposition on SWI may provide clues for diagnosis of BPAN in early childhood.
[ncbi.nlm.nih.gov]
Iron deposition was also observed in the globus pallidus.
[ncbi.nlm.nih.gov]
[…] accumulation (NBIA) corresponds to a group of disorders characterized by iron deposits in the basal ganglia [1].
[semanticscholar.org]
In its major form, beta-thalassemia requires monthly transfusions and a treatment against the harmful effect of iron deposits caused by these transfusions.
[presse.inserm.fr]
I only take an oral treatment, which is an antibiotic, because they had removed the spleen damaged by iron deposits related to the transfusions, editor’s note] and a hormone
[presse.inserm.fr]
Follow up images revealed further expansion of WM changes along with iron deposition in red nucleus and substantia nigra.
[n.neurology.org]
We found no correlation between iron deposition and neurologic involvement.
[ajnr.org]
Brain imaging typically reveals iron deposition in the globus pallidus and periventricular leukodystrophy.
[onlinelibrary.wiley.com]
Available data suggest that even in optimally chelated patients, cardiac pathology is abnormal secondary to iron deposition, fibrosis, hypertrophy, and the structural effects
[ncbi.nlm.nih.gov]
Mavrogeni S et al Magnetic resonance evaluation of liver and myocardium iron deposition in thalassemia intermedia and βthalassemia major.
[link.springer.com]
Magnetic resonance methods promise to provide more effective monitoring of iron deposition in vulnerable tissues, including the liver, heart, and endocrine organs, and could
[ncbi.nlm.nih.gov]
Microscopic examination of resected small bowel revealed prominent iron deposits in areas of necrosis, in basement membranes of lymphatics, capillaries, and venules, and within
[ncbi.nlm.nih.gov]
Hemochromatosis (iron deposits in organs) Excess iron is deposited in the liver, pancreas, brain, heart, joints and other body tissues leading to impairment of organ function
[arltma.com]
Congestion, edema, necrosis, and iron deposition in gastric and intestinal mucosa. Haemorrhage and congestion in the lungs.
[slideshare.net]
Abstract Ocular siderosis refers to intraocular iron deposition in ocular tissues caused by the long-time retention of penetrating iron-containing foreign bodies, commonly
[ncbi.nlm.nih.gov]
deposition in ocular tissues caused by the long-time retention of penetrating iron-containing foreign bodies, commonly leading to a series of characteristic alterations and
[semanticscholar.org]
Histological examination of specimens removed at the time of surgery showed iron deposition in the conjunctiva, anterior lens capsule and pars plana.
[ncbi.nlm.nih.gov]
These findings suggest that increased iron deposition may be related to pigment formation in the putamen of SND.
[ncbi.nlm.nih.gov]
SND may be associated with increased iron deposition in the putamen which can be detected with magnetic resonance imaging.
[ncbi.nlm.nih.gov]
Magnetic resonance imaging disclosed the presence of abnormal iron deposits in the putamen in all cases but showed no cortical anomalies.
[ncbi.nlm.nih.gov]
Definitive diagnosis of iron deposition generally requires invasive methods, such as direct tissue biopsy.
[ncbi.nlm.nih.gov]
Iron stain shows dense iron deposition (Row 1 Right 40X).
[librepathology.org]
Iron deposition in the heart is predominantly subepicardial. Due to the paramagnetic nature of the iron deposits, signal loss is seen on both T1 and T2 weighted images.
[med-ed.virginia.edu]
[…] and transferrin Brain MRI: increased iron Neurodegeneration with brain iron accumulation (NBIA; childhood) PANK-2 (pantothenate kinase) (AR) Iron deposit in basal ganglia
[mhmedical.com]
Iron deposition in many organs occurs. The excess iron affects organ function, presumably by direct toxic effect.
[library.med.utah.edu]
CT scan may be necessary to distinguish calcium from iron deposition.
[movementdisorders.org]
Iron deposition from joint bleeding, deep in synovial tissue, appears to be a key culprit.
[bloodjournal.org]
Pathobiological tissue changes are triggered by release of hemoglobin and iron deposition in the joint, but the sequence of events and the molecular mechanisms resulting in
[ncbi.nlm.nih.gov]
The pathogenesis of hemophilic arthropathy is incompletely understood but it may result from excessive iron deposition in synovial tissue and the cartilage which can serve
[link.springer.com]
[…] spheroids, and iron deposition in a typical distribution.
[jnnp.bmj.com]
CT scan may be necessary to distinguish calcium from iron deposition.
[movementdisorders.org]
Iron deposition was also noted, although less abundant than in the globus pallidus and in the same pattern of distribution.
[jnnp.bmj.com]
Little is known about renal iron deposition in β-thalassemia major (β-TM).
[ncbi.nlm.nih.gov]
Endocrinopathies Due to iron deposition in multiple endocrine glands inducing damage to those glands.
[pathophys.org]
In its major form, beta-thalassemia requires monthly transfusions and a treatment against the harmful effect of iron deposits caused by these transfusions.
[presse.inserm.fr]
Residual hemosiderosis (iron deposition) in the affected area may occur.
[medicinenet.com]
Visceral purpura is rare Bruises fade away within a few days but discoloration due to iron deposition at the trauma site lasts for long duration.
[ihealthblogger.com]
Iron deposition in the renal cortices of sickle-cell nephropathy patients may, at least in part, be responsible for the relatively diminished cortical signal intensity.
[ncbi.nlm.nih.gov]
[…] by decreasing iron deposition in tubule cells.
[academic.oup.com]
[…] to infarction and subsequent functional asplenia 94% are asplenic by age 5 1 radiological finding is of a small, calcified spleen splenic abscesses Hepatobiliary hepatic iron
[radiopaedia.org]
Iron deposition in the heart is predominantly subepicardial. Due to the paramagnetic nature of the iron deposits, signal loss is seen on both T1 and T2 weighted images.
[med-ed.virginia.edu]
Amyloid protein deposition can be seen as apple green birefringence upon microscopic examination. Iron deposition can be detected by biopsy as well.
[healio.com]
Amyloid protein deposition can be seen as apple green birefringence upon microscopic examination. Iron deposition can be detected by biopsy, as well.
[healio.com]
