Iron Deposition Causes & Reasons

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Iron Deposition Symptom Checker: Possible causes include Hemochromatosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Hemochromatosis

Non-HFE gene mutations may predispose HH patients to iron deposition in the brain. [ncbi.nlm.nih.gov]

When the 2 groups were compared for iron overload, iron deposition in the liver was significantly higher in group B (p 0.046). [ncbi.nlm.nih.gov]

Testicular atrophy, sometimes caused by excessive iron deposition in the testes, is a risk factor for testicular cancer. [ncbi.nlm.nih.gov]

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Hallervorden-Spatz Syndrome

Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI. [ncbi.nlm.nih.gov]

[…] spheroids, and iron deposition in a typical distribution. [jnnp.bmj.com]

Pathologically, there is iron deposition in the basal ganglia, with destruction of basal ganglia output neurons. [ncbi.nlm.nih.gov]

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Hemosiderosis

Pathology Some causes include: frequent transfusion mainly depositional siderosis in RES if 40 units transfused: then may cause hemochromatosis (non-RES iron deposition) high [radiopaedia.org]

Organs may be damaged by the iron deposits. The extent of the damage depends on how much iron is deposited in the organs. [merckmanuals.com]

(non-RES iron deposition) bantu siderosis : rare cause in Africa due to iron-laden locally brewed beer See also siderosis splenic siderosis hepatic siderosis pulmonary hemosiderosis [radiopaedia.org]

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African Iron Overload

Iron deposition is prominent both in macrophages and in hepatic parenchymal cells. [ncbi.nlm.nih.gov]

• This is a pathological state in which total body stores or iron are increased. • This can often result in organ dysfunction as a result of iron deposition List causes of [quizlet.com]

Heavy iron deposition in both hepatocytes and Kupffer cells was reported in individuals with Y64N FPN, 13 whereas iron deposition is predominantly in hepatocytes in C326Y [doi.org]

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Superficial Siderosis of the Central Nervous System

Evaluation of the cochlear nucleus revealed iron deposits within glial cells and larger cells, probably macrophages, near the CSF surface. [ncbi.nlm.nih.gov]

First described more than 100 years ago, only recently SS has been divided into two distinct entities, according to the distribution of iron deposition in the CNS: cortical [ncbi.nlm.nih.gov]

The diagnosis may be confirmed by computed tomography, which shows degeneration of the cerebellar vermis, and by magnetic resonance imaging, demonstrating iron deposits on [ncbi.nlm.nih.gov]

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Autosomal Recessive Spastic Paraplegia Type 43

Haplotype analysis revealed that the p.Ala63Pro mutations have a common origin, but MRI scans showed no brain iron deposition in the Malian SPG43 subjects. [experts.umich.edu]

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Sideroblastic Anemia

deposits in mitochondria of late erythroblasts and reticulocytes, and a high platelet count. [ncbi.nlm.nih.gov]

deposits within mitochondria. [ncbi.nlm.nih.gov]

A defining feature is excessive iron deposition within mitochondria of developing red cells, the consequences of which are an increase in cellular free radicals production [ncbi.nlm.nih.gov]

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Acquired Sideroblastic Anemia

In another case with no cytogenetic abnormality, repeated iron staining showed that 31% to 40% of CFU-E and 25% to 54% of BFU-E had erythroblasts with heavy iron deposits. [ncbi.nlm.nih.gov]

The red cell precursors from all patients showed the presence of electron-dense material in the mitochondria, representing most probably iron deposits. [ncbi.nlm.nih.gov]

[…] have increased bone marrow iron stores. 7 Increased iron deposits in patients with RARS have been described as finely granular or rarely coarsely granular. 8 In hemosiderosis [nature.com]

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Striatonigral Degeneration

Our histochemical studies support the concept that increased iron deposition in the putamen is responsible for this MRI picture. [ncbi.nlm.nih.gov]

These findings suggest that increased iron deposition may be related to pigment formation in the putamen of SND. [ncbi.nlm.nih.gov]

SND may be associated with increased iron deposition in the putamen which can be detected with magnetic resonance imaging. [ncbi.nlm.nih.gov]

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Hereditary Sideroblastic Anemia

The excess iron deposits as non-ferritin iron in the mitochondria that surround the nuclei of proerythroblasts (immature red blood cells). [themedicalbiochemistrypage.org]

Erythroid precursor shows iron deposits in mitochondrial cristae Differential diagnosis Chloramphenicol or TB drug (isoniazid) exposure, copper deficiency, alcohol or chronic [pathologyoutlines.com]

Immunodeficiency. [89] Bone marrow biopsy pathology: Erythroid precursors featuring perinuclear mitochondrial iron deposits (“ringed sideroblasts”). [89] Search Keywords: [autoinflammatory-search.org]

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Hypochromic Microcytic Anemia with Iron Overload Type 2

[…] are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. [malacards.org]

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Mitochondrial Membrane Protein-Associated Neurodegeneration

As the disease progressed, a repeat brain MRI showed iron deposition in the basal ganglia at nine years of age. [ncbi.nlm.nih.gov]

Neurodegeneration with brain iron accumulation (NBIA) refers to an inherited heterogeneous group of disorders pathologically characterized by focal brain iron deposition. [ncbi.nlm.nih.gov]

[…] degeneration of the central nervous system and high basal ganglia iron deposition. [ncbi.nlm.nih.gov]

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Neurodegeneration with Brain Iron Accumulation

[…] suggest a molecular link between iron deposition and alpha-synuclein accumulation. [ncbi.nlm.nih.gov]

Exact pathologic mechanism of iron deposition in NBIA remains unknown. [ncbi.nlm.nih.gov]

BACKGROUND: Neurodegeneration with brain iron accumulation (NBIA) defines a group of genetic disorders characterized by brain iron deposition and associated with neuronal [ncbi.nlm.nih.gov]

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Neuroferritinopathy

Iron deposition in the caudate head and cavitation in the lateral globus pallidus correlated with UDRS score (p 0.001). [ncbi.nlm.nih.gov]

Now that the molecular basis of the condition is known, therapeutic interventions to reduce or reverse brain iron deposition are being evaluated. [ncbi.nlm.nih.gov]

Ultrastructural analyses revealed an accumulation of lipofuscin granules associated with iron deposits, particularly enriched in the cerebellum and striatum of our transgenic [ncbi.nlm.nih.gov]

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Beta-Propeller Protein-Associated Neurodegeneration

Persistent elevation of NSE and iron deposition on SWI may provide clues for diagnosis of BPAN in early childhood. [ncbi.nlm.nih.gov]

Iron deposition was also observed in the globus pallidus. [ncbi.nlm.nih.gov]

[…] accumulation (NBIA) corresponds to a group of disorders characterized by iron deposits in the basal ganglia [1]. [semanticscholar.org]

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Ocular Siderosis

Abstract Ocular siderosis refers to intraocular iron deposition in ocular tissues caused by the long-time retention of penetrating iron-containing foreign bodies, commonly [ncbi.nlm.nih.gov]

deposition in ocular tissues caused by the long-time retention of penetrating iron-containing foreign bodies, commonly leading to a series of characteristic alterations and [semanticscholar.org]

Histological examination of specimens removed at the time of surgery showed iron deposition in the conjunctiva, anterior lens capsule and pars plana. [ncbi.nlm.nih.gov]

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Hemochromatosis-related Cardiomyopathy

Definitive diagnosis of iron deposition generally requires invasive methods, such as direct tissue biopsy. [ncbi.nlm.nih.gov]

Iron stain shows dense iron deposition (Row 1 Right 40X). [librepathology.org]

Iron deposition in the heart is predominantly subepicardial. Due to the paramagnetic nature of the iron deposits, signal loss is seen on both T1 and T2 weighted images. [med-ed.virginia.edu]

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Exostosis

Iron deposition in the bone is well known in some diseases associated with iron metabolism. [atlasofscience.org]

Publication Aluminum and iron can be deposited in the calcified matrix of bone exostoses. [atlasofscience.org]

We found that aluminum was deposited in the mineral phase of the bone in 2/3 of the patients. Iron was also detected in 1/3 of the patients. [atlasofscience.org]

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Vulvitis

Hemosiderin deposits. [6] DDx: Syphilis - Spirochete immunostain (in red) is helpful. Spongiotic vulvitis. Might look very similar. Usually wont show iron deposition. [librepathology.org]

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Cooley's Anemia

Available data suggest that even in optimally chelated patients, cardiac pathology is abnormal secondary to iron deposition, fibrosis, hypertrophy, and the structural effects [ncbi.nlm.nih.gov]

Magnetic resonance methods promise to provide more effective monitoring of iron deposition in vulnerable tissues, including the liver, heart, and endocrine organs, and could [ncbi.nlm.nih.gov]

Mavrogeni S et al Magnetic resonance evaluation of liver and myocardium iron deposition in thalassemia intermedia and βthalassemia major. [link.springer.com]

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Hemophilic Arthropathy

Pathobiological tissue changes are triggered by release of hemoglobin and iron deposition in the joint, but the sequence of events and the molecular mechanisms resulting in [ncbi.nlm.nih.gov]

Iron deposition from joint bleeding, deep in synovial tissue, appears to be a key culprit. [bloodjournal.org]

The pathogenesis of hemophilic arthropathy is incompletely understood but it may result from excessive iron deposition in synovial tissue and the cartilage which can serve [link.springer.com]

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Refractory Anemia

Before transfusion, neither a liver biopsy nor computed tomography scan demonstrated iron deposition in the organ parenchyma. [ncbi.nlm.nih.gov]

Whether this increase is associated with an increased repair of oxidative damage in DNA arising due to iron deposits in ring sideroblasts remains to be formally proven. [ncbi.nlm.nih.gov]

The iron deposited in perinuclear mitochondria of ring sideroblasts is present in the form of mitochondrial ferritin. [ncbi.nlm.nih.gov]

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Acute Iron Intoxication

Microscopic examination of resected small bowel revealed prominent iron deposits in areas of necrosis, in basement membranes of lymphatics, capillaries, and venules, and within [ncbi.nlm.nih.gov]

Hemochromatosis (iron deposits in organs) Excess iron is deposited in the liver, pancreas, brain, heart, joints and other body tissues leading to impairment of organ function [arltma.com]

Congestion, edema, necrosis, and iron deposition in gastric and intestinal mucosa. Haemorrhage and congestion in the lungs. [slideshare.net]

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Bladder Malakoplakia

Perls' stain (for iron deposits) revealed Michaelis–Gutmann bodies in cytoplasm of histiocytes, which are pathognomic of malakoplakia [Figure 2] a. [ijpmonline.org]

From the above results, M-G bodies can be assumed to be gradually formed by deposit of calcium, iron and others to the content of the phagolysosome containg bacteria products [jstage.jst.go.jp]

[…] of iron and calcium (known as Michaelis-Gutmann bodies) Treatment Antibiotics that concentrate in macrophages (quinolones or trimethoprim-sulfamethoxazole), antibiotics directed [pathologyoutlines.com]

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Beta Thalassemia

In its major form, beta-thalassemia requires monthly transfusions and a treatment against the harmful effect of iron deposits caused by these transfusions. [presse.inserm.fr]

I only take an oral treatment, which is an antibiotic, because they had removed the spleen damaged by iron deposits related to the transfusions, editor’s note] and a hormone [presse.inserm.fr]

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Thalassemia

Little is known about renal iron deposition in β-thalassemia major (β-TM). [ncbi.nlm.nih.gov]

Endocrinopathies Due to iron deposition in multiple endocrine glands inducing damage to those glands. [pathophys.org]

(due to endocrinal and hepatic iron deposition). 3) Thalassemia intermedia (BTI) in which the anemia is less severe and diagnosed later in life compared to BT-major. [orpha.net]

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Insect Bite

[…] beneficial in establishing a diagnosis of inflammatory dermatoses include Martius-Scarlet blue stain for fibrin, colloidal iron Hale’s for acid mucin, Prussian blue for iron [doi.org]

toluidine blue for mast cells, Fontana Masson for melanin pigment, elastic stain for perforating disorders and demonstration of elastic tissue, Von Kossa for calcium deposits [doi.org]

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Iron Deficiency

When the first organisms capable of photosynthesis began releasing oxygen into these iron-rich bodies of water, iron started forming as deposits on the Earth’s crust, which [steqtech.com]

Brain iron deposition in Parkinson’s disease imaged using the PRIME magnetic resonance sequence. Brain. 2000; 123 (Pt 12):2423–31. [ PubMed ] [ Google Scholar ] 55. [ncbi.nlm.nih.gov]

Most of this iron passes through the plasma for reutilization. Iron in excess of these requirements is deposited in body stores as ferritin or hemosiderin. [emedicine.com]

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Anemia

Anemia characterized by the presence of erythroblasts containing excessive deposits of iron in the marrow. 285 Other and unspecified anemias 285.0 Sideroblastic anemia convert [icd9data.com]

Thalassemia major, also called Cooley's anemia is a severe form of anemia where red blood cells are rapidly destroyed and iron is deposited in the vital organs. [kidshealth.org]

Nonneurologic findings Bone marrow hyperplasia Mild-to-moderate splenomegaly Increased iron deposits in the reticuloendothelial system Atrophy in all layers of the stomach [web.archive.org]

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Drug-induced Fever

Hemochromatosis – Liver is the storehouse for iron. Hemochromatosis can occur when there is too much iron deposited in the liver. This is usually a genetic condition. [news-medical.net]

They develop fatty deposits over the liver. They occur commonly in people that are obese, diabetic, and have high blood cholesterol. [news-medical.net]

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