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46 Possible Causes for Iron Deposition in Hepatocytes

  • Hemochromatosis

    […] within hepatocytes, initially heavy periportal parenchymal iron deposition with sparing of Kupffer cells Iron distribution is pericanalicular, particularly in less involved[pathologyoutlines.com] Excess iron deposited in hepatocytes results in toxicity that can lead to cirrhosis, which may be the most important prognostic factor in patients with hereditary hemochromatosis[aafp.org] Definition / general Excessive accumulation of iron, usually deposited in liver, pancreas and heart Either primary or secondary Normal iron pool is 2 - 6 gm with 0.5 g in[pathologyoutlines.com]

  • Alcoholic Liver Disease

    deposition: usually mild; mainly in hepatocytes (grade 1 - 2) and occasionally in Kupffer cells Microscopic (histologic) images Images hosted on other servers : Liver biopsy[pathologyoutlines.com] […] obliteration of terminal hepatic venule (phlebosclerosis) due to perivenular fibrosis; severe form of alcoholic hepatitis associated with noncirrhotic portal hypertension Iron[pathologyoutlines.com]

  • Macronodular Cirrhosis

    Hemosiderin deposition in hepatocytes which simulates fibrogenesis, most iron overload cirrhosis show little inflammation, diagnosis is possible ante-mortem when iron deposition[omicsgroup.org] The special stain for hemosiderin, Prussian blue reaction was positive showed iron deposition in periportal hepatocytes and bile duct epithelium, kupffer cells absence of[omicsgroup.org] iron in septate which are seen in cases of secondary hemochromatosis.[omicsgroup.org]

  • Hereditary North American Indian Childhood Cirrhosis

    In this scenario, marked iron deposits may be present in hepatocytes at birth, giving rise to the term neonatal iron storage disease, or perinatal hemochromatosis. 5 A severe[clinicalgate.com] One dramatic exception to the concept of physiologic iron deposition occurs in newborns who exhibit liver failure at birth, which is usually attributable to severe liver injury[clinicalgate.com]

  • Cryptogenic Cirrhosis

    Hemosiderin deposition in hepatocytes which simulates fibrogenesis, most iron overload cirrhosis show little inflammation, diagnosis is possible ante-mortem when iron deposition[omicsonline.org] The special stain for hemosiderin, Prussian blue reaction was positive showed iron deposition in periportal hepatocytes and bile duct epithelium, kupffer cells absence of[omicsonline.org] iron in septate which are seen in cases of secondary hemochromatosis.[omicsonline.org]

  • Hepatocellular Carcinoma

    For example, chronic infection with the hepatitis virus, the deposition of iron and copper, and steatosis of the liver are risk factors that can contribute to HCC emergence[doi.org] […] could induce oxidative stress in hepatocytes and cause the emergence of HCC.[doi.org] [ 3 ]; all of these factors also reportedly induce oxidative stress in hepatocytes.[doi.org]

  • Drug-induced Toxic Hepatitis

    Iron stain shows 3 iron deposition. C. A reticulin stain shows changes of injury.[librepathology.org] Iron stain shows predominantly hepatocellular iron deposition [green arrows] with occasional Kupffer cell staining [black arrows]. E.[librepathology.org] Regeneration is seen in two-three hepatocyte cords [blue arrows] and hepatocyte rosettes [magenta arrows]; canaliculi are not highlighted by reticulin stain. D.[librepathology.org]

  • African Iron Overload

    Heavy iron deposition in both hepatocytes and Kupffer cells was reported in individuals with Y64N FPN, 13 whereas iron deposition is predominantly in hepatocytes in C326Y[doi.org] […] derived from the iron drums and cans used for brewing traditional alcoholic beverages. 2 The histologic findings were distinctive, with the bulk of the iron being deposited[bloodjournal.org] Histologic Analysis of Liver-Biopsy Specimens The deposition of iron in hepatocytes was graded on a scale of 0 to 4, 8, 9 the presence or absence of iron was noted in cells[doi.org]

  • Renal Cysts and Diabetes Syndrome

    deposition in hepatocytes and Kupffer cells; persistent hematopoiesis Atrophic head; absent body and tail Fecal elastase deficiency Transient hyperglycemia at 3 mo; permanent[wjgnet.com] […] renal and hepatic dysfunction; acidosis; hyperglycemia Hypoplastic hyperechogenic kidneys; cortical cysts Progressive chronic renal insufficiency by 7 yr Mild steatosis; iron[wjgnet.com]

  • Hemosiderosis

    Nonalcoholic Fatty Liver Disease Granular iron deposits in hepatocytes and/or RES similar to alcoholic liver disease have been reported in 1% to 95% of patients with nonalcoholic[es.slideshare.net] Histologically, iron deposition within hepatocytes rather than Kupffer cells is typical, with iron deposition to a lesser degree occurring in non-hepatic organs as well.[nature.com] […] ballooning, and sinusoidal iron; and had a lower incidence of the C282Y mutation (C282Y heterozygosity and compound heterozygosity).[57] Hepatocellular iron deposits were[es.slideshare.net]

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