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91 Possible Causes for Iron Increased, Lactate Dehydrogenase Increased, Reticulocyte Count Decreased

  • Iron Deficiency Anemia

    Normal 0.5-1.5% Hypoprolifearative: Decreased reticulocytes Bone marrow unable to produce requisite number of RBC's Lack of essential substance (iron, B12, folate) or invasion[meddean.luc.edu] This is because your need for iron increases during these times of growth and development.[web.archive.org] Increased demand: Iron deficiency can occur during rapid periods of growth.[irondisorders.org]

  • Pernicious Anemia

    Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count.[ncbi.nlm.nih.gov] Individuals suffering iron deficiency might take oral iron supplements and increase their dietary iron intake, while individuals suffering from pernicious anemia might receive[livestrong.com] Response should be monitored by reticulocyte counts, lactic dehydrogenase (LDH), and an appropriate rise in hemoglobin levels.[emedicine.medscape.com]

  • Folate-Deficiency Anemia

    Significant blood test findings include macrocytosis, decreased reticulocyte count, abnormal platelets, and a serum folate less than 4 mg/ml.[innvista.com] Dangers of anaemia and iron deficiency less iron passing from mother to foetus so the newborn has low iron stores increased risk of blood loss during and after delivery, and[southsudanmedicaljournal.com] Iron deficiency anemia is due to insufficient iron, either from inadequate dietary intake or from increased iron losses.[livestrong.com]

  • Acute Myelocytic Leukemia

    An iron stain usually shows increased iron stores and may show ring sideroblasts (Figure 2, B [inset]).[archivesofpathology.org] The potential for neurotoxicity has aroused concern about the use of high-dose cytarabine in elderly patients who, ironically, have a higher likelihood of having drug-resistant[doi.org] […] in the patients who received high-dose cytarabine in our trial 45 ; the risk of neurotoxicity was less than 1 percent if none or one of these factors was present, but it increased[doi.org]

  • Leukemia

    Leukemia is cancer of the blood forming tissues that also affects the bone marrow and the lymphatic system. Such a type of cancer causes abnormal development of cells that gradually enter the bloodstream. Symptoms of leukemia vary with the type. The common symptoms of the disease include the following: Undue[…][symptoma.com]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    Mitochondrial pathology in MDS is suggested by abnormal mitochondrial iron accumulation, increased apoptosis, and a high frequency of acquired mitochondrial DNA mutations[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] At 1 year following partial splenectomy, mean hemoglobin significantly increased by 3.0 1.4 g/dL (n 52), reticulocyte count decreased by 6.6% 6.6% (n 41), and bilirubin level[ncbi.nlm.nih.gov] Indications for laparoscopic removal of the spleen included anemia unresponsive to iron supplementation in eight patients (66.6 %) with increase need for red cells transfusions[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    The high NADH inhibits conversion of lactate to pyruvate by Lactate dehydrogenase, malate to oxaloacetate by Malate dehydrogenase, which decreases the availability of pyruvate[pubs.sciepub.com] Coexisting iron accumulation or chronic hepatitis C increases risk of hepatocellular carcinoma.[merckmanuals.com] Other factors that may trigger type 1 PCT include oestrogen, iron and viral infections (especially hepatitis C).[dermnetnz.org]

  • Non-Hodgkin Lymphoma

    Most of the aggressive lymphomas present with a rapidly growing tumor mass, fever, night sweats, weight loss, and increased levels of serum lactate dehydrogenase and uric[symptoma.com] Regarding our 3rd case, the laboratory findings revealed leukocytosis, anemia, thrombocytosis, increased inflammatory biomarkers, elevated LDH, and a low level of iron.[ncbi.nlm.nih.gov] One indicator of the potential for tumor lysis syndrome is an elevated plasma lactate dehydrogenase level or hyperuricemia at the time of diagnosis.[emedicine.medscape.com]

  • Thalassemia

    At the end of the treatment period, Hb and HbF increased by 2.5   1.8 g/dL and 2.5   1.6 g/dL, while bilirubin, lactate dehydrogenase, and the nucleated red blood cell count[ncbi.nlm.nih.gov] The predominant mechanisms driving the process of iron loading include increased iron burden secondary to transfusion therapy in TDT and enhanced intestinal absorption secondary[ncbi.nlm.nih.gov] Reticulocytes, LDH and bilirubin are increased; haptoglobin is decreased.[lecturio.com]

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