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150 Possible Causes for Iron Increased, Reticulocyte Count Decreased, Splenomegaly

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count.[ncbi.nlm.nih.gov] Individuals suffering iron deficiency might take oral iron supplements and increase their dietary iron intake, while individuals suffering from pernicious anemia might receive[livestrong.com]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly.[icd9data.com] […] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly[web.archive.org]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] An iron stain usually shows increased iron stores and may show ring sideroblasts (Figure 2, B [inset]).[archivesofpathology.org] The potential for neurotoxicity has aroused concern about the use of high-dose cytarabine in elderly patients who, ironically, have a higher likelihood of having drug-resistant[doi.org]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    Mitochondrial pathology in MDS is suggested by abnormal mitochondrial iron accumulation, increased apoptosis, and a high frequency of acquired mitochondrial DNA mutations[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] At 1 year following partial splenectomy, mean hemoglobin significantly increased by 3.0 1.4 g/dL (n 52), reticulocyte count decreased by 6.6% 6.6% (n 41), and bilirubin level[ncbi.nlm.nih.gov] Indications for laparoscopic removal of the spleen included anemia unresponsive to iron supplementation in eight patients (66.6 %) with increase need for red cells transfusions[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Leukopenia and Thrombocytopenia due to direct bone marrow effect, but also from cirrhosis/splenomegaly.[errolozdalga.com] Coexisting iron accumulation or chronic hepatitis C increases risk of hepatocellular carcinoma.[merckmanuals.com] Other factors that may trigger type 1 PCT include oestrogen, iron and viral infections (especially hepatitis C).[dermnetnz.org]

  • Iron Deficiency Anemia

    […] symptoms Physical findings: Impaired growth and development in children Pallor of the mucous membranes Spoon-shaped nails with decreased capillary refill Angular stomatitis Splenomegaly[symptoma.com] Normal 0.5-1.5% Hypoprolifearative: Decreased reticulocytes Bone marrow unable to produce requisite number of RBC's Lack of essential substance (iron, B12, folate) or invasion[meddean.luc.edu] This is because your need for iron increases during these times of growth and development.[web.archive.org]

  • Aplastic Anemia

    Three patients had pre-treatment hematological abnormalities related to splenomegaly.[ncbi.nlm.nih.gov] For example, for a person with anemia, an inappropriately low reticulocyte count often indicates decrease in red blood cell production in the bone marrow .[labtestsonline.org] We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Symptoms and Signs Myeloid metaplasia may result in splenomegaly, particularly in patients with storage diseases.[merckmanuals.com] Decreased count - reticulocyte levels drop where there is marrow infiltration (leukaemia, myeloma, lymphoma or other malignancies) or due to marrow underactivity such as in[patient.info] RBC protoporphyrin increased BM- ringed sideroblasts Iron studies- Increased serum iron, increased iron saturation, increased ferritin- Decreased TIBC Anemia of Chronic Disease[quizlet.com]

  • Non-Hodgkin Lymphoma

    Computed tomography scan of the chest and abdomen showed paratracheal and subcarinal lymphadenopathy and splenomegaly, with the findings being compatible with lymphoma.[ncbi.nlm.nih.gov] Regarding our 3rd case, the laboratory findings revealed leukocytosis, anemia, thrombocytosis, increased inflammatory biomarkers, elevated LDH, and a low level of iron.[ncbi.nlm.nih.gov] Splenomegaly. Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info]

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