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173 Possible Causes for Iron Increased, Transferrin Saturation Increased

  • Hemochromatosis

    Recent studies have shown an increased concentration of redox-active iron in plasma in patients with increased transferrin saturation.[] saturation.[] Transferrin saturation may remain increased when body iron stores and SF values are subnormal; phlebotomy that reduces transferrin saturation to low normal values may result[]

  • Portal Cirrhosis

    Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis, [1] is named after René Laennec, [2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture is lost, with fibrosis (scarring) and later[…][]

  • Acute Intermittent Porphyria

    […] concentration was slightly elevated; and (f) heme oxygenase I mRNA was increased approximately three-fold.[] Periodic monitoring of serum ferritin concentration and/or transferrin saturation is therefore appropriate in individuals treated repeatedly with hemin.[] Ferrokinetic studies in one patient also demonstrated decreased erythropoiesis (plasma iron turnover was 70 per cent of normal).[]

  • Aplastic Anemia

    We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox.[] Stainable iron is usually increased; however, the presence of increased ringed sideroblasts suggests a diagnosis of MDS.[] Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels.[]

  • Sideroblastic Anemia

    Decreased ferritin increases synthesis of transferrin (increasing TIBC); such as seen in iron deficiency anemia.[] In sideroblastic anemia serum iron, serum ferritin and transferrin saturation are increased.[] However, in contrast, there are features of iron deficiency (normal/decreased serum iron, normal/low transferrin iron saturation, increased serum transferrin receptor concentration[]

  • Thalassemia

    The predominant mechanisms driving the process of iron loading include increased iron burden secondary to transfusion therapy in TDT and enhanced intestinal absorption secondary[] Abstract Iron overload (IOL) due to increased intestinal iron absorption constitutes a major clinical problem in patients with non-transfusion-dependent thalassemia (NTDT)[] , suggesting the importance of increased iron burden as a HCC risk factor in this patient population.[]

  • Acute Hepatic Porphyria

    […] hepatic iron store s, hemochromatosis Alcoho l, smoking Hepatitis C HIV Estrogen therapy Sunlight exposure Pathophysiology Clinical findings Cutaneous manifestations Increased[] […] porphyria [ por-fēr e-ah ] a genetic disorder characterized by a disturbance in porphyrin metabolism with resultant increase in the formation and excretion of porphyrins ([] Ironically, treatment with anti-psychotics increases the accumulation of porphrobiliogen, thus aggravating the disease enough that it may prove fatal.[]

  • Thalassemia Minor

    The RBC counts increased after iron therapy, although the change was not significant.[] An increased iron turnover from low-grade hemolysis of microcytic erythrocytes may lead to hepatic damage and increased oxidative stress, both of which can contribute to insulin[] In our patients, serum iron increased significantly with values reaching the normal range.[]

  • Cooley's Anemia

    Iron overload is also induced by the increased gastrointestinal absorption of iron, increased hemolysis and ineffective erythropoiesis seen in beta thalassemia major.[] Large doses of ascorbic acid can assist in increasing iron output to avoid iron overload Splenectomy if hypersplenism exists, especially if transfusion requirements are increasing[] The increased HbA2 may be masked in patients with concomitant iron deficiency and in patients with a delta-beta thalassemia trait.[]

  • Glycogen Storage Disease Type 1

    […] serum iron Renal Fanconi syndrome Pancreatic hypoplasia Renal cortical cysts Ureteropelvic junction obstruction Abnormality of iron homeostasis Abnormality of the anterior[] saturation Maturity-onset diabetes of the young Bicornuate uterus Photophobia Cognitive impairment Behavioral abnormality Atherosclerotic lesion Hyperlipoproteinemia Acute[] Maturity-onset diabetes of the young Bicornuate uterus Photophobia Cognitive impairment Behavioral abnormality Atherosclerotic lesion Hyperlipoproteinemia Acute pancreatitis Increased[]

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