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102 Possible Causes for Irritability, Nocturnal Leg Cramp, Seizure

  • Hypoglycemia

    An infant presented with short history of jaundice and irritability, examination showed soft hepatomegaly.[ncbi.nlm.nih.gov] Postoperatively the patient demonstrated both generalized and focal seizure activity.[ncbi.nlm.nih.gov] […] behavior lightheadedness unsteady movement inability to concentrate personality changes headache restlessness depressed mood tingling in the hands, feet, lips, or tongue irritability[glucagenhypokit.com]

  • Chronic Alcoholism

    […] neglect of physical appearance and proper nutrition, alcohol-related illness (such as hepatitis or cirrhosis of the liver), and moderate to severe withdrawal symptoms (such as irritability[merriam-webster.com] Report of a case of SESA syndrome: a rare CNS complication of chronic alcoholism, known since 1981 and characterized by epileptic seizures, multiple and reversible neurological[ncbi.nlm.nih.gov] They may wake up next morning with a headache, feeling irritable, but that is as far as it goes.[eskimo.com]

  • Chronic Kidney Insufficiency

    […] of 100.4 F (38 C) or higher, or as advised by your healthcare provider Blood in your urine or stool Bloody discharge from your nose, mouth, or ears Severe headache or a seizure[fairview.org] End stage renal disease causes weight loss, nausea and vomiting, fatigue, difficulty breathing and seizures.[kidneyandhypertensioncare.com] , persistent itchy skin muscle twitching or cramping a yellowish-brown tint to the skin As the kidney failure gets worse and the toxins continue to build up in the body, seizures[medbroadcast.com]

  • Insulinoma

    She reported a 30-minute period of fatigue, confusion, poor concentration, irritability, and “staring off” which was noted by parents while the patient was getting ready for[ijpeonline.biomedcentral.com] Hypoglycemia can cause multiple neuroglycopenic symptoms; seizures being one of them.[ncbi.nlm.nih.gov] We present the case of a 70 year old man who was admitted with history of generalized tonic clonic seizures on and off since 6 years in spite of being on regular therapy with[ncbi.nlm.nih.gov]

  • Hyponatremia

    This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp.[ncbi.nlm.nih.gov] Post-transplant seizures are uncommon in young kidney transplant recipients but can be harbingers of devastating outcomes such as cerebral edema and death.[ncbi.nlm.nih.gov] He seems irritable and has a hard time remembering where he is and why he’s in the hospital. Soon he becomes lethargic.[americannursetoday.com]

  • Hypocalcemia

    Hypocalcemia: Lower-than-normal level of calcium in the blood, which makes the nervous system highly irritable, as evidenced by tetany (spasms of the hands and feet, muscle[rxlist.com] We report the case of an inaugural episode of generalized seizures in a 40-year-old male with a history of chronic kidney disease associated with TSC2-PKD1 contiguous gene[ncbi.nlm.nih.gov] The smooth muscles of internal organs can become irritable and cause conditions such as spasms in the lungs and irritation of the gallbladder.[livestrong.com]

  • Hypomagnesemia

    It causes increased irritability of the nervous system with tetany (spasms of the hands and feet, muscular twitching and cramps, spasm of the larynx, and overly active reflexes[medterms.com] Isolated hypomagnesemia of the idiopathic form is a rare condition that is known to present as generalized motor seizures in children.[ncbi.nlm.nih.gov] Magnesium ion (Mg2 ) deficits, as reflected in hypomagnesemia, can cause neuromuscular irritability, seizures and cardiac arrhythmias.[ncbi.nlm.nih.gov]

  • Hyperthyroidism

    This leads to a wide range of symptoms including weight loss, increased appetite, increased sweating, intolerance to heat, anxiety and irritability.[symptoma.com] F 38.9 - 39.4 C / 102 - 102.9 F 39.5 - 39.9 C / 103 - 103.9 F 40 C / 104 F CNS Effects: Absent Mild (agitation) Moderate (delirium, psychosis, extreme lethargy) Severe (seizure[formatio-reticularis.de] 101 to 101.9 15 102 to 102.9 20 103 to 103.9 25 104 30 Central nervous system effects Absent 0 Mild 10 Agitation Moderate 20 Delirium Psychosis Extreme lethargy Severe 30 Seizure[aafp.org]

  • Graves Disease

    It can cause irritability, sleeplessness and absence of voluntary muscle movements. Elliot was detected with Graves’ disease in 2008.[healthresearchfunding.org] A dramatic increase in thyroid hormones can result in fever, delirium, severe weakness, seizures, markedly irregular heartbeat, yellow skin and eyes, severe low blood pressure[sbs.com.au] This disease presents clinically with variable symptoms, such as seizures, neuropsychiatric changes, or focal neurologic deficits.[ajnr.org]

  • Restless Legs Syndrome

    In the older age-onset patients, misdiagnoses also included skin irritation, arthritis, and malingering.[ncbi.nlm.nih.gov] Two common causes of pain or discomfort in legs are nocturnal leg cramps (NLC) and restless leg syndrome (RLS).[doi.org] Perampanel is a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) antagonist that has been approved for the treatment of partial seizures[ncbi.nlm.nih.gov]

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