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1,750 Possible Causes for Jaundice, Leukopenia

  • Infectious Mononucleosis

    We report a case of infectious mononucleosis in a 72-year old jaundiced gentleman with ferritin level of 2438 that normalised on clinical improvement.[ncbi.nlm.nih.gov] Leukopenia and thrombocytopenia are not uncommon.[ncbi.nlm.nih.gov] […] mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely with jaundice[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] The authors report a 57-year-old male patient who presented with diarrhea, darkened urine, jaundice and increased blood urea nitrogen and creatinine.[ncbi.nlm.nih.gov]

  • Yellow Fever

    For more than 95% of acute febrile jaundice cases identified through surveillance for yellow fever, a reemerging arthropod-borne viral disease, no etiological exploration[ncbi.nlm.nih.gov] These include: Complete blood count: The findings in a complete blood count for patients with yellow fever include leukopenia, thrombocytopenia, increased hemoglobin and hematocrit[symptoma.com] High fevers associated with bradycardia, leukopenia, and transaminase elevations may provide a clue to the diagnosis, and patients will be viremic during this period.[nejm.org]

  • Malaria

    A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] Anemia, Leukopenia, and thrombocytopenia are commonly observed hematological abnormalities in malaria and typhoid patients.[ncbi.nlm.nih.gov] Infant presented with pallor, jaundice and massive spleen. Laboratory tests revealed anaemia, thrombocytopenia and bilirubinemia.[ncbi.nlm.nih.gov]

  • Plasmodium Falciparum Malaria

    In severe cases, it can cause jaundice, seizures, coma, or death.[ncbi.nlm.nih.gov] Fever (100%), splenomegaly (86.7%), hepatomegaly (26.7%), leukopenia (13.3%), thrombocytopenia (80%), elevated liver function tests (40%), and increased serum creatinine levels[ncbi.nlm.nih.gov] A 13-year-old adolescent daughter of a missionary presented with fever and jaundice 1 week after returning from Africa.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Jaundice: There is mild jaundice caused by the excessive breakdown of hemoglobin due to ineffective erythropoiesis in the bone marrow.[symptoma.com] A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] Intravenous Lipid Emulsion-Associated Catatonia, Thrombocytopenia, and Leukopenia: A Case Report and the Role of NMDA Receptor .[bjp.rcpsych.org]

  • Viral Hepatitis

    Jaundice is a rare clinical presentation in typhoid fever, therefore hepatitis A should be considered in typhoid fever and jaundice because both enterically transmitted disease[ncbi.nlm.nih.gov] Fever, nausea, vomiting, abdominal pain, leukopenia, thrombocytopenia, coagulopathy, and a marked rise in serum transaminase levels are invariably present.[ncbi.nlm.nih.gov] […] autopsy due to nonspecific clinical features Better survival in children than adults ( J Hepatol 2011;55:1222 ) Laboratory Sudden, marked elevation of ALT or AST, fever, leukopenia[pathologyoutlines.com]

  • T-Cell Lymphoma

    Aggressive NK cell leukemia – this lymphoma presents with acute systemic symptoms including fever, jaundice, lymphadenopathy, and hepatomegaly.[symptoma.com] Grade 3/4 leukopenia occurred in 43 (23.4%) patients. Major non-hematological toxicities included nausea (n 117, 63.6%) and vomiting (n 66, 35.9%).[ncbi.nlm.nih.gov] Priest Jaundice as a paraneoplasic phenomenon in a T cell lymphoma Gastroenterology, 97 (1989), pp. 1319-1322 [12.] S. Holt,Z. Varghese,M. Jarmulowicz,R. Marley,P.[analesdepediatria.org]

  • Hepatitis B

    As symptoms of abdominal pain and jaundice were presented on the fifth day, he re-admitted. The patient expired because of hepatorenal and cardiac insufficiency.[ncbi.nlm.nih.gov] Peripheral blood counts may show mild leukopenia, with or without relative lymphocytosis.[clevelandclinicmeded.com] You may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. Some people have no symptoms at all.[medlineplus.gov]

  • Gaucher Disease

    Investigations General assessment FBC and differential (assess the degree of pancytopenia); LFTs (minor elevations of liver enzymes are common but jaundice is a poor prognostic[patient.info] Decreased platelet counts (thrombocytopenia) as well as low hemoglobin (anemia) and decreased white blood cell counts (leukopenia) result in easy bruisability and hence black-and-blue[scientificamerican.com] The gastrointestinal features include hepatosplenomegaly, jaundice , hepatic (liver) failure, and ascites (fluid in the abdomen).[medicinenet.com]

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