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870 Possible Causes for Jaundice, Leukopenia, Pancytopenia

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Jaundice: There is mild jaundice caused by the excessive breakdown of hemoglobin due to ineffective erythropoiesis in the bone marrow.[symptoma.com] A deficiency of white blood cells ( leukopenia ) and platelets ( thrombocytopenia ) in the blood may occur.[britannica.com] The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov]

  • Acute Arsenic Poisoning

    .  The other symptoms produced as a result of poisoning are  Jaundice,  Dark red urine,  Renal failure,  Heart failure,  Delirium and  Coma.  Death usually instantaneous[slideshare.net] ) and easy bruising / petechia (thrombocytopenia) Anemia and leukopenia are common in chronic arsenic toxicity, are often accompanied by thrombocytopenia and mild eosinophilia[pathologyoutlines.com] AAP can lead to several hematological ailments that are exemplified by bone marrow suppression leading to normocytic anemia or pancytopenia, disseminated intravascular coagulation[symptoma.com]

  • Myelodysplasia

    An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[ncbi.nlm.nih.gov] Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy.[ncbi.nlm.nih.gov] Can present with symptoms of anaemia, leukopenia, and thrombocytopenia, but often found during routine laboratory investigations in asymptomatic patients.[bestpractice.bmj.com]

  • Severe Aplastic Anemia

    Tell your health care provider right away if you have any of these signs and symptoms of liver problems: yellowing of the skin or the whites of the eyes (jaundice) unusual[us.promacta.com] Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections).[msdmanuals.com] Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[ncbi.nlm.nih.gov]

  • Malaria

    A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] Anemia, Leukopenia, and thrombocytopenia are commonly observed hematological abnormalities in malaria and typhoid patients.[ncbi.nlm.nih.gov] Infant presented with pallor, jaundice and massive spleen. Laboratory tests revealed anaemia, thrombocytopenia and bilirubinemia.[ncbi.nlm.nih.gov]

  • Multicentric Castleman's Disease

    Jaundice may be noted. Additional complaints consistent with MCD are xerostomia, rash and neurological deficits.[symptoma.com] Case report In 1994, a 19 years old girl presented with a non-erosive bilateral arthritis of hands and wrists, leukopenia and hypocomplementemia.[zdoc.site] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    Obstructive jaundice: an unusual initial manifestation of intra-abdominal non-Hodgkin lymphoma in a child.[journals.lww.com] The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection.[ncbi.nlm.nih.gov] Complete blood count revealed pancytopenia with abnormal lymphoid cells.[ncbi.nlm.nih.gov]

  • Brucellosis

    […] year-old Hispanic man presented to a University Hospital in Chía, Colombia, with a complaint of 15 days of fatigue, weakness, decreased appetite, epigastric abdominal pain, jaundice[ncbi.nlm.nih.gov] Leukopenias associated with thrombocytopenia were observed. BMA showed to be normal.[ncbi.nlm.nih.gov] Pancytopenia improved with treatment of brucellosis on all patients.[ncbi.nlm.nih.gov]

  • Malignant Histiocytosis

    The clinical course was rapidly progressive and terminated with jaundice and respiratory failure.[ncbi.nlm.nih.gov] Two years later, he manifested persistent fever, leukopenia, effusions and hypoproteinemia, and his general condition worsened progressively.[ncbi.nlm.nih.gov] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[ncbi.nlm.nih.gov]

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