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18 Possible Causes for Jaundice, Mutation in the CDK6 Gene

  • Biliary Carcinoma

    We present a woman diagnosed with metastatic breast cancer in the CBD after presenting with obstructive jaundice.[karger.com] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] We present the third case of metastatic lung cancer to the common bile duct presenting as abdominal distention and jaundice.[omicsonline.org]

  • Gallbladder Carcinoma

    A 52-year-old woman presented with right upper quadrant pain and obstructive jaundice.[ncbi.nlm.nih.gov] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] The clinical presentation, comprised of nonspecific signs such as abdominal pain in the right upper quadrant, weight loss, jaundice, and fever, is often insidious.[symptoma.com]

  • Malignant Gastric Neoplasm

    Jaundice and pallor may be apparent as well.[symptoma.com] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] […] eating Nausea or vomiting after meals Trouble swallowing Persistent burping (belching) Stomach ulcer that doesn’t go away Fluid buildup (ascites) in the abdomen (belly) Jaundice[uclahealth.org]

  • Adenocarcinoma of Gallbladder and Extrahepatic Biliary Tract

    The most common symptoms were abdominal discomfort (45%) and jaundice (28%).[doi.org] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Obstructive jaundice may not be necessary. The tumor thrombus were loose.[cancerjournal.net]

  • Pancreatic Neoplasm

    We report a pancreatobiliary fistula caused by an intraductal papillary-mucinous pancreatic neoplasm (IPMN), manifesting as obstructive jaundice.[ncbi.nlm.nih.gov] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] […] pan kreas L, cancer, crab a malignant neoplastic disease of the pancreas characterized by anorexia, flatulence, weakness, dramatic weight loss, epigastric or back pain, jaundice[medical-dictionary.thefreedictionary.com]

  • CDK4-linked Melanoma

    Congenital hepatic cyst causing jaundice: report of a case and analogies with respiratory malformation. Ann Surg. 1964 Apr. 159:585-92. [Medline].[emedicine.medscape.com] However, we are not aware of CDK6 mutations associated with melanoma ( 48 ).[cancerres.aacrjournals.org] There was no history of trauma, fever, jaundice or weight loss. She had not suffered any major illness in the past.[oatext.com]

  • Gastric Cancer

    Key words: Stomach neoplasm;Obstructive jaundice[e-crt.org] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] We report on a patient with obstructive jaundice caused by recurrence of gastric carcinoma in the wall of an extrahepatic bile duct more than 5 years after gastrectomy who[ncbi.nlm.nih.gov]

  • Gastric Adenocarcinoma

    This report describes two cases with obstructive jaundice caused by poorly differentiated gastric adenocarcinoma.[ncbi.nlm.nih.gov] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] With the development of complications, the patient may experience jaundice and peritoneal or pleural effusions, due to metastases or hypoalbuminemia caused by inanition.[symptoma.com]

  • Rhabdomyosarcoma

    Biliary duct localization is extremely rare, but it is the most common cause of malignant obstructive jaundice in pediatric patients.[ncbi.nlm.nih.gov] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov] (sinusitis), nosebleeds, congestion, headaches, vomiting, constipation, blocked urinary bladder, scrotal mass, blood/fluid discharge from vagina, yellowing of the eyes (jaundice[dovemed.com]

  • Glioblastoma Multiforme

    Possible symptoms include jaundice, indigestion, poor appetite, color changes of urine and stool, weight loss, and a sudden change in blood sugar levels.[livestrong.com] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org] In these areas, the healing process would have removed the infarcted tissue, resulting in encephalomalacia and atrophy, if the patient had not died (the jaundiced patient[doi.org]

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