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13 Possible Causes for Jaundice, Mutation in the CDK6 Gene, Personality Change

  • Biliary Carcinoma

    We present a woman diagnosed with metastatic breast cancer in the CBD after presenting with obstructive jaundice.[karger.com] If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org]

  • Malignant Gastric Neoplasm

    Jaundice and pallor may be apparent as well.[symptoma.com] Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com]

  • Glioblastoma Multiforme

    Possible symptoms include jaundice, indigestion, poor appetite, color changes of urine and stool, weight loss, and a sudden change in blood sugar levels.[livestrong.com] General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org]

  • Pancreatic Neoplasm

    We report a pancreatobiliary fistula caused by an intraductal papillary-mucinous pancreatic neoplasm (IPMN), manifesting as obstructive jaundice.[ncbi.nlm.nih.gov] Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • Gastric Cancer

    Key words: Stomach neoplasm;Obstructive jaundice[e-crt.org] Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Gastric Adenocarcinoma

    This report describes two cases with obstructive jaundice caused by poorly differentiated gastric adenocarcinoma.[ncbi.nlm.nih.gov] Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Rhabdomyosarcoma

    Biliary duct localization is extremely rare, but it is the most common cause of malignant obstructive jaundice in pediatric patients.[ncbi.nlm.nih.gov] Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov]

  • Acute Myelomonocytic Leukemia

    CASE REPORT A 74-year-old Hispanic woman from Ecuador presented to the emergency department with a five-day history of fever, jaundice, and right upper quadrant abdominal[ncbi.nlm.nih.gov] CML is an acquired leukemia, resulting from a change in a person's DNA. This change results in an uncontrolled growth of white cells.[nationalcmlsociety.org] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com]

  • Familial Melanoma of the Lip

    He underwent stenting of the common bile duct for relief of obstructive jaundice. Atypical moles are more common in people of northern European Celtic background.[e-ijd.org] A positive test would not really change a person’s treatment or care. Patients should still see their specialist regularly and be advised to practice sun protection.[genomel.org] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • Autosomal Dominant Microcephaly

    No lymphedema was observed in his hands and feet and the patient also did not present anemia, petechiae, maculopapular rash or jaundice.[scielo.br] WNT5A Selected Pathogenic Variants DNA Nucleotide Change (Alias 1 ) Predicted Protein Change (Alias 1 ) Reference Sequences c.206G A p.Cys69Tyr NM_003392 .4 NP_003383 .2 c[ncbi.nlm.nih.gov] […] in the ZNF335 gene ({610827}) on 20q13; MCPH11 ({615414}), caused by mutation in the PHC1 gene ({602978}) on 12p13; MCPH12 ({616080}), caused by mutation in the CDK6 gene[diseaseinfosearch.org]

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