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10 Possible Causes for Jaundice, Non-Hemolytic Unconjugated Hyperbilirubinemia

  • Gilbert Syndrome

    The role of GS in neonatal jaundice is unknown.[ncbi.nlm.nih.gov] Constitutional liver dysfunction Familial non-hemolytic non-obstructive jaundice Icterus intermittens juvenilis Low-grade chronic hyperbilirubinemia Unconjugated benign bilirubinemia[en.wikipedia.org] Tagged as: constitutional liver dysfunction, familial benign unconjugated hyperbilirubinaemia, familial non-hemolytic non-obstructive jaundice, Gilbert–Meulengracht syndrome[highrisklifeinsuranceagency.com]

  • Crigler-Najjar Syndrome Type 1

    Clinically apparent jaundice is unusual in patients with beta-thalassemia major.[ncbi.nlm.nih.gov] Mutations in the UGT1A1 gene cause Crigler-Najjar syndrome (CN), which causes non-hemolytic unconjugated hyperbilirubinemia, and is categorized as CN1 and CN2 according to[ncbi.nlm.nih.gov] Crigler-Najjar (CN) syndrome is a rare autosomal recessive inherited disorder characterized by non-hemolytic, unconjugated hyperbilirubinemia.[ncbi.nlm.nih.gov]

  • Massive Hepatic Necrosis

    Cook GC, Sherlock S: Jaundice and its relation to therapeutic agents.[link.springer.com] Gilbert’s Disease Chronic, benign, intermittent, familial (AD), non-hemolytic unconjugated hyperbilirubinemia with evanescent increases of B1 Due to defective transport and[slideshare.net] Jaundice tnetic Shock 1 Noted to be Jaundiced on day he died 1 Hal 44 Jaundiced last day of life 1 3 Hal 74 History of hepatic disease 9 1 Cyclo 185 Jaundiced last day 1 2[nap.edu]

  • Dubin-Johnson Syndrome

    Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia.[ncbi.nlm.nih.gov] Dubin-Johnson syndrome (DJS, OMIM 237500) is a rare, autosomal recessive disorder characterized by non-hemolytic hyperbilirubinemia with no progression to end-stage liver[wjgnet.com] Our patient represents a case of digenic mixed hyperbilirubinemia-a distinct type of constitutive jaundice resulting from coinherited defects in ABCC2/MRP2 and UGT1A1 genes[ncbi.nlm.nih.gov]

  • Pyruvate Kinase Deficiency

    Pyruvate kinase deficiency may cause pregnancy-associated jaundice.[ncbi.nlm.nih.gov] It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia.[ncbi.nlm.nih.gov] PK deficiency is not a common cause of neonatal jaundice. However, this needs further investigation on a larger scale.[ncbi.nlm.nih.gov]

  • Crigler-Najjar Syndrome Type 2

    The only physical sign of hyperbilirubinemia is jaundice. Crigler-Najjar syndrome may be suspected in neonates if jaundice lasts longer than usual.[symptoma.com] In severe CNS-I, the absence of UGT1A1 enzyme activity lead to non-hemolytic unconjugated hyperbilirubinemia, marked jaundice and may cause bilirubin encephalopathy (kernicterus[bmcpediatr.biomedcentral.com] Crigler-Najjar syndrome A moderate to severe form of hereditary jaundice. Crigler, John F., U.S. physician, 1919–.[medical-dictionary.thefreedictionary.com]

  • Early Infantile Epileptic Encephalopathy Type 6

    In the absence of jaundice, splenomegaly, or complications the disease may remain undetected.[centogene.com] More severe liver injury can cause nausea, vomiting, abdominal pain, fatigue, anorexia, jaundice and/or dark urine.[fda.gov] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com]

  • Brandt Syndrome

    Symptoms may include: Fatigue Yellowing of the skin and whites of the eyes (mild jaundice) In people with Gilbert syndrome, jaundice most often appears during times of exertion[medlineplus.gov] This is a symptom of jaundice . Jaundice usually appears within 20 days after the onset of symptoms.[healthline.com] When infantile papular acrodermatitis is caused by hepatitis B, there may be an enlarged liver, but there is seldom any jaundice .[dermnetnz.org]

  • Hereditary Elliptocytosis 2

    An excess of bilirubin can cause jaundice. Jaundice causes the skin to turn yellowish or bronze. The whites of the eyes can also turn yellow.[healthline.com] , resulting from exacerbated hemolysis) Chronic, non-immune hemolytic anemia High mean corpuscular hemoglobin concentration (MCHC) Presence of spherocytes in the peripheral[centogene.com] […] of jaundice.[stepwards.com]

  • Dicarboxylic Aminoaciduria

    Term Intrahepatic Jaundice: causes and forms Definition Jaundice caused by defects in the uptke of free bilirubin, conjugation of bilirubin to form bilirubin diglucuronide[flashcardmachine.com] Cringler-Najjar Syndrome : a form of congenital non-hemolytic/intrahepatic jaundice. Toxic hyperbilirubinemia caused by alcohol-induced liver damage or by Acetomenophin.[flashcardmachine.com] Term Definition 5% of the population has this form of Intrahepatic Jaundice which is normally asymptomatic.[flashcardmachine.com]

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