Jaundice & Pancytopenia & Polyclonal Hyperglobulinemia: Causes & Reasons

Neu starten

Ad Html Headline Ad Text Headline

Ad Label Ad Html Description Ad Text Description

Determine your risk of now. Restart test

Caution! In case of an emergency:

Seek emergency care

Caution! In case of an emergency: Seek emergency care

Hi, I'm Symptoma.

For full functionality of this site it is necessary to enable JavaScript.

How to enable JavaScript?

Patient File

Sex unknown, Age unknown

Reported Symptoms

Jaundice, Pancytopenia, Polyclonal Hyperglobulinemia,

Negated

None

Unsure

None

Possible Causes

Multicentric Castleman's Disease

Jaundice may be noted. Additional complaints consistent with MCD are xerostomia, rash and neurological deficits. [symptoma.com]

hyperglobulinemia, elevated transaminases and renal disease. 2, 5, 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients. [pagepress.org]

Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present. [ncbi.nlm.nih.gov]

Show info

Gaucher Disease

The disorder can result in pain, fatigue, jaundice, bone damage, anaemia and even death. Gaucher disease is an autosomal recessive disorder. [brainfoundation.org.au]

Very often Gaucher disease is connected with immune system abnormalities as polyclonal hyperglobulinemia which is present at 14-41% of adult patients at the time of diagnosis [oatext.com]

[…] w/ severe thrombocytopenia is seen; - splenectomy offers temporary relief but pancytopenia may recur w/ depletion of the normal marrow elements; - Radiographs: - fusiform [wheelessonline.com]

Show info

Chronic Active Hepatitis B

The symptoms of liver cancer include weight loss, loss of appetite, nausea and vomiting, and jaundice. [news-medical.net]

hyperglobulinemia. [hepatitiscentral.com]

A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia. [ncbi.nlm.nih.gov]

Show info

Primary Myelofibrosis

• No rash, bleeding gums, swelling of joints, bone pain, fever, night sweats, cough with expectoration, hemoptysis, chest pain, orthopnoea, PND • No h/o jaundice, abdominal [slideshare.net]

Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis. [patient-help.com]

This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets). [aoporphan.com]

Show info

Polycythemia Neonatorum

Gallery images and information: Diagnosis Polycythemia Neonatorum pic source Neonatal Jaundice 1 638 x 479 jpeg 79kB pic source Neonatal Jaundice 1 638 x 479 jpeg 54kB pic [mnogolok.info]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

pancytopenia D61.82 Myelophthisis Includes: Leukoerythroblastic anemia Myelophthisic anemia Panmyelophthisis Excludes 1: idiopathic myelofibrosis (D47.1) myelofibrosis NOS [app.drchrono.com]

Show info

Chronic Active Hepatitis

In a patient with chronic hepatitis who has already suffered relapses a search for a second cause of jaundice is not usually necessary. [ncbi.nlm.nih.gov]

hyperglobulinemia. [hepatitiscentral.com]

Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia. [ncbi.nlm.nih.gov]

Show info

Congenital Intrinsic Factor Deficiency

Affected infants may experience repeated episodes of extreme anemia and jaundice. [rarediseases.org]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level [treatable-id.org]

Show info

HIV Infection

[…] dysfunction, and a bleeding tendency (particularly in people with hemophilia) Amprenavir (APV) Rash Atazanavir (ATV) Rash and yellowing of the skin and whites of the eyes (jaundice [merckmanuals.com]

Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened [hivinsite.ucsf.edu]

[…] osteomalacia* Protease inhibitors with statins: myopathy Hematologic or oncologic Anemia of chronic disease Lymphoma, multiple myeloma Bone marrow infiltration (leading to pancytopenia [aafp.org]

Show info

Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

Clinical description Clinically, PK-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at [orpha.net]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

[…] and thrombotic emboli (e.g., infarctions, Budd-Chiari syndrome ) Risk of acute leukemias Think of PNH if a patient presents with hemolytic anemia, venous thrombosis, and pancytopenia [amboss.com]

Show info

Posthemorrhagic Anaemia of the Newborn

History: Family: Anemia during pregnancy, ethnicity, jaundice in anamnesis Maternal and perinatal: Blood type and Rh; anemia; complications of labor or delivery Neonatal: [slideplayer.com]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

[…] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia [theodora.com]

Show info

Anemia due to Glutathione Metabolism Disorder

[…] synthetase deficiency HNSHA due to glutathione reductase deficiency Leukocyte glucose-6-phosphate dehydrogenase deficiency Muscle phosphofructokinase deficiency Neonatal jaundice [icd9data.com]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

Anemia and jaundice are noted in the neonatal period. Jaundice may be severe enough to require exchange transfusion. [medcaretips.com]

Show info

Castleman Disease

Bo Zhai, Hai-Yang Ren, Wei-Dong Li, Shiva Reddy, Shu-Jun Zhang and Xue-Ying Sun, Castleman disease presenting with jaundice: A case report and review of literature, World [dx.doi.org]

The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy. [ncbi.nlm.nih.gov]

There is often significant anemia which may be hemolytic, often reflecting pancytopenia or hemophagocytic syndrome (Stebbing 2009). [hivbook.com]

Show info

MALT Lymphoma

An 86-year-old female was referred to our hospital manifesting obstructive jaundice and abdominal pain. [ncbi.nlm.nih.gov]

Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia. [ncbi.nlm.nih.gov]

In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid [ncbi.nlm.nih.gov]

Show info

H Syndrome

At 6.5 months of age, he developed non-bilious non-bloody emesis and diarrhea, followed within a week by jaundice, decreased appetite and low-grade fevers to 101 F. [ped-rheum.biomedcentral.com]

IVIC Syndrome with mild thrombocytopenia and leukocytosis; 4) WT Syndrome involving a wide array of hematologic abnormalities including easy bruising, hypoplastic anemia, pancytopenia [bloodjournal.org]

See also: floater in vision White ring around iris arcus White spot on eye See: spot on eye, white or cloudy Yellow eyes jaundice Yellow spot on eye See: spot on eye, yellow [allaboutvision.com]

Show info

Polyclonal Hypergammaglobulinemia

Clinical features Can be associated with fever, leukocytosis, skin rash May also see lymphadenopathy, dyspnea, hepatosplenomegaly, jaundice Case specific presentation varies [pathologyoutlines.com]

NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia [icd10coded.com]

Visceral leishmaniasis causes irregular fever, hepatosplenomegaly, pancytopenia, and polyclonal hypergammaglobulinemia with high mortality in untreated patients. [msdmanuals.com]

Show info

Angioimmunoblastic Lymphadenopathy

Dapsone-Induced Hypersensitivity Syndrome Abstract A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice [jpatholtm.org]

In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%). [emedicine.medscape.com]

Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ... [citeulike.org]

Show info

Hyperglobulinemic Purpura

The majority of causes of jaundice can be found on clinical history and examination. [accessmedicine.mhmedical.com]

Other immunologic abnormalities include a polyclonal hyperglobulinemia and positive tests for cryoglobulins; these cryoglobulins may contain monoclonal IgMK proteins. [enotes.tripod.com]

Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy [en.wikisource.org]

Show info

Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

[…] autoimmune lymphoproliferative syndrome (ALPS), which is very unusual with regard to a clinical onset soon after birth, and a clinical picture dominated by splenomegaly, jaundice [ncbi.nlm.nih.gov]

NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia [icd10coded.com]

[…] lymphoproliferative syndrome (ALPS) is a rare, newly recognized, chronic lymphoproliferative disorder in children and is characterized by lymphadenopathy, splenomegaly, pancytopenia [ncbi.nlm.nih.gov]

Show info

Idiopathic Cryoglobulinemia

Avoid in newborns due to the potential for an increase in free bilirubin, jaundice, and development of kernicterus. [healthnutvitamin.com]

NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia [icd10coded.com]

• However, a high rate of hematologic side effects (mainly grade 3 and 4 pancytopenia) was recorded. 1. Saadoun D, et al. [slideshare.net]

Show info

IgG4 Syndrome

Six months later, the patient developed pruritus and jaundice. His serum bilirubin was 7.9 mg/dL (direct 5.1 mg/dL). Other liver function tests are shown in Table 1. [the-rheumatologist.org]

hyperglobulinemia. [hematologyandoncology.net]

Further investigations Blood test results showed pancytopenia, leucocytes 3,100 10 9 /L, haemoglobin 10.1 g/dL, haematocrit 28.9%, and platelets 117,000 10 9 /L. [revistanefrologia.com]

Show info

Recurrent Infection due to Specific Granule Deficiency

In contrast, the CD3-/ CD56 NK-cell disorders are clinically aggressive, occurring in younger patients and presenting with fever, massive hepa- tosplenomegaly, jaundice and [europeanmedical.info]

Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1. [clinicalmolecularallergy.biomedcentral.com]

Hemophagocytic Lymphohistiocytosis HL is a rapidly fatal disorder, occurring as a familial or acquired condition; it is characterized by fever, pancytopenia, hepatic dysfunction [what-when-how.com]

Show info

Autosomal Recessive Agammaglobulinemia Type 3

[…] convulsions, severe anemia– 5g/dL and 10 000 parasites mm3, acidosis–plasma bicarbonate 15 mmol/L, hemoglobinuria, renal failure, spontaneous bleeding Supporting criteria Jaundice [medical-dictionary.thefreedictionary.com]

NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign [en.wikisource.org]

Fanconi Anemia Autosomal Recessive congenital pancytopenia. Normocytic anemia with neutropenia. [kumc.edu]

Show info

Immunodeficiency due to a Classical Component Pathway Deficiency

Defects Disorder Inheritance Gene Affected Clinical Findings Chédiak-Higashi syndrome Autosomal recessive LYST (CHS1) Oculocutaneous albinism, recurrent infections, fever, jaundice [msdmanuals.com]

Hypergammglobulinemia such as a polyclonal increase is associated with an autoimmune disorder, Hypergammaglobulinemia such as a monoclonal increse is associated with multiple [flashcardmachine.com]

Chédiak-Higashi syndrome Autosomal recessive LYST (CHS1) Oculocutaneous albinism, recurrent infections, fever, jaundice, hepatosplenomegaly, lymphadenopathy, neuropathy, pancytopenia [msdmanuals.com]

Show info

⚕ Symptoma®️ is a digital health assistant but no replacement for the opinion and judgement of medical professionals. By using this website you fully understand and accept that it shall not be used as a diagnostic system for decision-making. It absolutely must not be used to obtain, replace or overrule a clinical diagnosis by a healthcare professional. It is always for the medical professional to make the final diagnosis. The medical information provided on this website is of a general nature and can not substitute for the advice of a medical professional (for example, a qualified doctor or physician)! Information from the internet could and should NOT be solely used to offer or render a medical opinion or otherwise engage in the practice of medicine.