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62 Possible Causes for Jaundice, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia Type 1

    Thus, we should be aware of the possibility of CDA if the etiology of congenital anemia or jaundice cannot be clearly elucidated.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] Congenital dyserythropoietic anemia type I (CDA1) can present in utero with hydrops fetalis, but more often it presents in childhood or adulthood with moderate macrocytic anemia, jaundice[]

  • Hemolytic Anemia

    The existence of a primary form of acquired hemolytic jaundice has been questioned more and FULL TEXT[] Mean corpuscular volume was 96 fl, and the reticulocyte count was 11%, with marked polychromasia on peripheral smear.[] The diagnosis of Zieve syndrome was confirmed based on hemolysis and cholestatic jaundice secondary to alcoholic liver disease and heavy drinking.[]

  • Autoimmune Hemolytic Anemia

    Secondary AIHA might not be diagnosed appropriately because the obstructive jaundice observed in type 1 AIP/IgG4-SC can obscure the presence of hemolytic jaundice.[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[] A 48 year old lady presented with jaundice and exertional breathlesness.[]

  • Congenital Dyserythropoietic Anemia

    , Neonatal/diagnosis Jaundice, Neonatal/etiology Jaundice, Neonatal/therapy Microscopy, Electron Phototherapy Pregnancy[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] Patients share chronic anemia of variable severity and jaundice, frequently associated with splenomegaly and/or hepatomegaly.[]

  • Microangiopathic Hemolytic Anemia

    A newborn infant with a large hepatic hemangioma developed congestive heart failure, consumption coagulopathy, microangiopathic hemolytic anemia, and obstructive jaundice.[] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[] (See also jaundice .) Bleeding under the skin and bruises in response to the slightest trauma often are present in anemic and leukemic patients.[]

  • Zieve's Syndrome

    Zieve's syndrome is a disorder that manifests with anemia, jaundice, and hyperlipidemia, in the setting of alcoholism and hepatic cirrhosis.[] The peripheral blood smear revealed polychromasia and nucleated erythrocytes. The parents’ blood counts and smears were normal.[] The patient's peripheral smear showed polychromasia, macrocytosis, tear drop cells, ovalocytes, spur cells, and schistocytes ( Figure 1 ).[]

  • Paroxysmal Cold Hemoglobinuria

    Should the kidneys be affected as well, the condition may progress to the renal dysfunction that presents with oliguria or even anuria in extreme circumstances; jaundice and[] Tests include complete blood count (CBC) and peripheral smear.[] Following an episode, affected individuals usually develop the signs of hemolysis including yellowing of the skin, whites of the eyes and mucous membranes (jaundice).[]

  • Pyruvate Kinase Deficiency

    Pyruvate kinase deficiency may cause pregnancy-associated jaundice.[] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[] RESULTS: 7 of the 218 cases of neonatal jaundice were PK deficient with 30-40% reduction in PK activity.[]

  • Hemolytic Uremic Syndrome

    A week later, he presents to the ER with jaundice, abdominal pain, and easy bruising. Lab results come back with low platelet count, anemia, and increased creatinine.[] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[] Lethargy Passing out blood in urine or very less urinary output Weakness Irritability Confusion Pain in the abdomen Development of swelling in the arms, feet and face Pallor Jaundice[]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    G6PD deficiency is found to one important cause of neonatal jaundice developing on day 2 onwards.[] The peripheral blood smear showed polychromasia, anisopoikilocytosis and reticulocytosis (the reticulocyte count was 14.6%). Urine was positive for hemoglobinuria.[] We report the first case (to the best of our knowledge) of acute jaundice without overt clinical features of a haemolytic crisis, in an otherwise healthy adult female following[]

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