Joint Stiffness & Muscle Weakness & Progressive Contractures: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Joint Stiffness, Muscle Weakness, Progressive Contractures,

Negated

None

Unsure

None

Possible Causes

Congenital Muscular Dystrophy

We report the first known Egyptian patient with FCMD, established by clinical features of generalized weakness, pseudohypertrophy of calf muscles, progressive joint contractures [ncbi.nlm.nih.gov]

CMD results in overall muscle weakness with possible joint stiffness or looseness. [mda.org]

KEYWORDS: Collagen; Fibrosis; IGF-1; Mesenchymal; Mouse; Muscular dystrophy; Skeletal muscles; Weakness [ncbi.nlm.nih.gov]

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Rheumatoid Arthritis

Erosion of the articular cartilage, together with ligamentous changes, result in deformity and contractures. As the disease progresses, pain and deformity increase. [orthoinfo.aaos.org]

The common signs include joint stiffness, swelling, pain, redness and warmth. These are typical hallmarks of inflammation. [techtimes.com]

Fatigue, muscle weakness, and weight loss are common symptoms. [britannica.com]

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Fibrodysplasia Ossificans Progressiva

This case however presents a very aggressive form of disease with patient developing spontaneous swellings and progressive contractures. [ijcasereportsandimages.com]

Tissue swelling, joint stiffness and serious discomfort can occur. Some may have a low-grade fever. Flare-ups can last as long as six to eight weeks. [ucsfbenioffchildrens.org]

* Malformed fingers * Malformed toes * Limited joint movement * Muscle weakness * Rigid muscles * Tendon weakness * Rigid tendons * Calcium deposits in muscles * Movement [checkorphan.org]

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Arthrogryposis Multiplex Congenita

Abstract Arthrogryposis multiplex congenita (AMC) is a rare disorder characterized by non-progressive, multiple contractures. [ncbi.nlm.nih.gov]

Arthrogryposis multiplex congenita (AMC) is a complex disorder that leads to joint stiffness and deformities in 2 or more joints in afflicted children. [ncbi.nlm.nih.gov]

This condition is accompanied by increased muscle weakness. Physical therapist Lynn Grabe of Children’s Hospital in St. Paul, MN details Anna’s aquatic therapy journey. [hydroworx.com]

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Mucopolysaccharidosis

hip containment surgeries; corrective osteotomy for progressive valgus deformity at the knee; posterior spinal fusion Multispecialty care is mandatory for these patients [emedicine.medscape.com]

[…] medullary compression, general osteoporosis, lungs/heart dysfunction, pectus carinatum (malformation of the chest characterized by a protrusion of the sternum and ribs), muscle [hindawi.com]

Progressive upper airway disease leads to obstructive sleep apnoea. [patient.info]

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Hemophilia

This disease can lead to further symptoms such as: • progressive decreased motion • flexion contractures • muscle atrophy [1] The second most common presentation of hemophilia [physio-pedia.com]

Ultimately this process will cause chronic joint stiffness and pain. [emedicinehealth.com]

Weak muscles don't support the joints as well, making bleeding episodes more frequent. [web.archive.org]

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Progressive Pseudorheumatoid Dysplasia

These joints develop progressive contractures. [ncbi.nlm.nih.gov]

Typical signs are prominent epiphysis, progressive joint stiffness, muscle weakness and early fatigue [ 1 ]. [ped-rheum.biomedcentral.com]

INTERPRETATION: The deficits can be attributed to pronounced muscle weakness plus functional joint impairment and pain. [ncbi.nlm.nih.gov]

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Osteoarthritis

Another characteristic symptom of the disease is the progressive inability of joint function, leading -in the long run- to loss of mobility. [oafifoundation.com]

The absolute reduction in finger joint stiffness for the exercise group, compared with the control group, was 7% (3% to 10%). [ncbi.nlm.nih.gov]

As a progressive degenerative joint disorder, OA is characterized by cartilage damage, changes in the subchondral bone, osteophyte formation, muscle weakness, and inflammation [ncbi.nlm.nih.gov]

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Mucopolysaccharidosis Type 7

Affected individuals may have developmental delay and progressive intellectual disability, although intelligence is unaffected in some people with this condition. [ghr.nlm.nih.gov]

Cataracts Clouding of the corneas Developmental delay Enlarged spleen and liver Joint stiffness Hearing loss Heart and lung complications Short stature How many people have [ultrarareadvocacy.com]

Common problems include abnormal heart valves, narrowing of the blood vessels in the heart, and weak heart muscles (cardiomyopathy). [encyclopedia.com]

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Muscle Spasticity

Spasticity-related muscle dysfunction is characterized by muscle hyperactivity/hypertonicity, motor weakness, and, in progressed cases, contracture of adjacent soft tissue [bmcneurol.biomedcentral.com]

BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, [ncbi.nlm.nih.gov]

Muscle weakness and spasticity will be evaluated in both groups of subjects. [clinicaltrials.gov]

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Schwartz-Jampel Syndrome

[…] cartilages, joint contractures, blepharophimosis, unusual pinnae, myopia, pigeon breast, and progressive stiffness of the face and limbs (14–16). [spandidos-publications.com]

Limited joint mobility leads to an unsteady gait. Joint stiffness is progressive, reaching its peak during adolescence. [orpha.net]

554 Case 89A A Woman with Muscle Weakness and a Skin Rash 559 Case 90 A Man with Muscle Pains 567 Case 91 An Older Woman with Progressive Muscle Weakness 572 Case 92 An HIVInfected [books.google.com]

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Emery-Dreifuss Muscular Dystrophy

Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a neuromuscular disorder resulting in progressive muscle weakness, contractures, and cardiomyopathy. [ncbi.nlm.nih.gov]

The condition causes slowly progressive (worsening) weakness in the muscles of the shoulders, upper arms, and lower legs and joint stiffness (contractures). [nationwidechildrens.org]

In some of the patients, muscle weakness distribution was more widespread than has usually been reported, with prominent involvement of finger extensors. [ncbi.nlm.nih.gov]

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Joint Contracture

[…] of molecular treatment to prevent the progression of joint contracture prior to intervention with physical therapy. [ncbi.nlm.nih.gov]

Case studies: Contracture and stiff joint management with Dynasplint. J Orthop Sports Phys Ther. 1987;8:498-504. Steffen TM, Mollinger LA. [aetna.com]

Seventy per cent (70%) of participants had muscle weakness in one or more muscle groups. [multiple-sclerosis-research.blogspot.com]

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Arthritis

Dupuytren’s contracture tends to affect the pinkie and ring fingers and generally progresses very slowly. [medicalnewstoday.com]

Arthritis is the inflammation of one or more joints. The main symptoms are joint pain, swelling and stiffness. [symptoma.com]

Abstract BACKGROUND: Arthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. [ncbi.nlm.nih.gov]

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Muscular Dystrophy

In DMD and some cases of BMD there is progressive weakness, contractures and the inability to walk. [healthengine.com.au]

There may be stiff joints (contractures) due to the baby not being able to move the joints enough. [patient.info]

It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest. [ninds.nih.gov]

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Bethlem Myopathy Type 2

The disease is characterized by slowly progressive muscle weakness and joint stiffness (contractures ). [rarediseases.info.nih.gov]

The bilateral (10º) hip flexion contractures were initially noted, which evolved to 20º, in knee flexion bilaterally (50º), progressing to -60º in the third evaluation and [pepsic.bvsalud.org]

The child presented from birth severe congenital hypotonia and generalized muscle weakness with proximal predominance. [scielo.br]

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Muscular Dystrophy-Dystroglycanopathy Type C4

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Some develop joint stiffness (contractures) that can restrict movement in their hips, knees, ankles, or elbows. [lgmd-info.org]

Other symptoms may be present in some of the different subtypes of LGMD, including but not limited to: joint stiffness, muscle cramps, enlargement of calf muscles and involvement [mda.org]

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Polyarthritis

The characteristic rapid progression of palmar contracture is a key finding that suggests the potential existence of a malignancy. [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

OBJECTIVES: Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or unspecified polyarthritis (UA) deal with several symptoms such as joint stiffness, pain, [ncbi.nlm.nih.gov]

But she had noticed generalized muscle pain and proximal muscle weakness. [imedpub.com]

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Emery-Dreifuss Muscular Dystrophy Type 1

Confusion with the common idiopathic toe walking inhibits therapy and prophylaxis of progressive contractures and skeleton deformities. [zehenspitzengang.de]

Another prominent aspect of EDMD is the appearance of contractures (stiff joints) in the elbows, neck and heels very early in the course of the disease. [mda.org]

NCI Thesaurus A group of inherited progressive muscle disorders characterized by muscle weakness and eventual death of the muscle tissues. [doctor.am]

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Limb-Girdle Muscular Dystrophy Type 2Q

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Affected people may experience protruding of the shoulder blade, joint stiffness, and overgrowth of the calf muscles. Intellect is generally not affected. [geneaware.clinical.bcm.edu]

Autosomal recessive limb-girdle muscular dystrophy-17 is characterized by early childhood onset of proximal muscle weakness and atrophy without skin involvement. [ncbi.nlm.nih.gov]

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Limb-Girdle Muscular Dystrophy Type 2A

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Affected people may experience protruding of the shoulder blade, joint stiffness, and overgrowth of the calf muscles. Intellect is generally not affected. [geneaware.clinical.bcm.edu]

Other symptoms may be present in some of the different subtypes of LGMD, including but not limited to: joint stiffness, muscle cramps, enlargement of calf muscles and involvement [mda.org]

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Systemic Scleroderma

With disease progression, ulcerations over joints and flexion contractures of the fingers, wrists, and elbows may occur. [aafp.org]

stiffness/pain Limited cutaneous systemic sclerosis In 90% of cases, Raynaud's phenomenon precedes the onset of other symptoms. [amboss.com]

weakness [my.clevelandclinic.org]

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Arthrogryposis due to Muscular Dystrophy

Genetic Testing 12(1): 53-56, 2008 Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures. [m.eurekamag.com]

Children born with AMC often experience joint stiffness (also known as joint contracture) and muscle weakness. [gillettechildrens.org]

Glossary Amyotrophy -Muscle wasting or weakness Atrophy -when motor neurons in the cord are damaged the muscles become weak and shrink in size Fasciculations -muscle twitching [childneurologyfoundation.org]

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Enthesitis-Related Arthritis

A subset of children with ERA will progress to ankylosing spondylitis (AS), a condition characterized by spinal and back pain, stiffness, and eventual fusion of the vertebra [grantome.com]

Joint stiffness occurs primarily in the morning or after long periods of inactivity (gelling phenomenon). [childrenshospital.org]

When the disease is active, up to 10% of patients will develop systemic manifestations such as fever, weight loss, fatigue, muscle weakness, muscle atrophy, and lymphadenopathy [symptoma.com]

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Limb-Girdle Muscular Dystrophy

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Some develop joint stiffness (contractures) that can restrict movement in their hips, knees, ankles, or elbows. [lgmd-info.org]

However, most patients in the current family showed distal as well as proximal limb weakness rather than weakness of toe and finger flexor muscles that were typical features [ncbi.nlm.nih.gov]

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Nemaline Myopathy Type 5

contractures. [institut-myologie.org]

stiffness, worse in the morning Restricted shoulder motion ESR CRP Normal Normal Normal Organ system Disease Age of onset Muscle weakness Fever Myalgia Contractures Gait [wikidoc.org]

[…] disorder defined on the basis of muscle weakness and the presence of structural abnormalities in the muscle fibres, i.e. nemaline bodies. [biochemj.org]

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X-linked Distal Spinal Muscular Atrophy Type 3

[…] for alignment -Joystick modifications -Contracture development 2* prolonged sitting -Progression of scoliosis - High incidence -Surgery for spinal stabilization What are [quizlet.com]

[…] mobility / joint stiffness / ankylosis - X-linked recessive inheritance Frequent - Broad nose / nasal bridge - Clasp thumb / thumb adduction / distal thumb phalangeal bone [csbg.cnb.csic.es]

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Limb-Girdle Muscular Dystrophy Type 2E

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Some develop joint stiffness (contractures) that can restrict movement in their hips, knees, ankles, or elbows. [lgmd-info.org]

Symptoms - Limb-girdle muscular dystrophy- type 2E Weakness Toe walking Muscle pain Muscle cramps Shoulder girdle muscle weakness Causes - Limb-girdle muscular dystrophy- [checkorphan.org]

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Limb-Girdle Muscular Dystrophy Type 2J

There is variable rate of progression. May develop myalgia, myoglobinuria, contractures, muscle hypertrophy. [patient.info]

Other symptoms may be present in some of the different subtypes of LGMD, including but not limited to: joint stiffness, muscle cramps, enlargement of calf muscles and involvement [mda.org]

Muscle weakness may spread from the proximal muscles to affect distal muscles. [rarediseases.org]

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Neurogenic Arthrogryposis Multiplex Congenita

Arthrogryposis ( multiplex congenita ) is a clinical or imaging descriptor that denotes congenital non-progressive joint contractures involving two or more body regions. [radiopaedia.org]

Affiliated tissues include heart, spinal cord and skin, and related phenotypes are joint stiffness and short nose Disease Ontology : 12 A nervous system disease characterized [malacards.org]

Some of the associated abnormalities could be attributed to muscle weakness, occurring during intrauterine development. [unboundmedicine.com]

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