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28 Possible Causes for Karyotype Abnormal, Luteinizing Hormone Low, Testicular Biopsy Abnormal

  • Klinefelter Syndrome

    Cytogenetic examination revealed the abnormal karyotype of 47,XXY. There are no clear references as to diagnosing the Klinefelter's syndrome.[ncbi.nlm.nih.gov] Endocrinological examination revealed a high growth hormone (GH) concentration, low testosterone concentration, and high follicle-stimulating hormone and luteinizing hormone[ncbi.nlm.nih.gov] Testicular biopsies of KS infants and boys demonstrated decreased or absent germ cells and abnormal seminiferous tubules ( 16, 50 – 52 ).[dx.doi.org]

  • Orchitis

    Genetic disorders of the ovary are associated with karyotypic abnormalities and are discussed in Dysgerminomas in patients with karyotypic abnormalities in Complications.[emedicine.medscape.com] […] in mumps orchitis, have found low testosterone levels, elevated luteinizing hormone (LH) levels and an exaggerated pituitary response to LH-releasing hormone stimulation[jpbsonline.org] […] occur in about 13% of patients while 30-87% of patients with bilateral mumps orchitis experience infertility. [10] Studies by Adamopoulos et al. on the levels of various hormones[jpbsonline.org]

  • Sertoli Cell-Only Syndrome

    karyotypes.[en.wikipedia.org] Plasma testosterone, LH (luteinizing hormone), and FSH (follicle-stimulating hormone) measurements are helpful in separating these conditions.[taldon.org] Human testicular biopsy specimens were obtained from patients suffering from post-testicular infertility (testis showing normal spermatogenesis, 10 cases) and testicular infertility[ncbi.nlm.nih.gov]

  • Hypogonadism

    Causes of primary hypogonadism include: Karyotype abnormalities—Klinefelter syndrome (47, XXY syndrome) is the most common Toxin exposure, chemotherapy Congenital defects—anorchia[mdedge.com] hormone ( 9.4 mU/mL)], secondary (low total testosterone, low/normal luteinizing hormone), primary (low total testosterone, elevated luteinizing hormone) and compensated[ncbi.nlm.nih.gov] If tests confirm that you have low testosterone, further testing can determine if a testicular disorder or a pituitary abnormality is the cause.[mayoclinic.org]

  • Anorchia

    Abstract We report an anorchic patient with normal male phenotype and 46,XY karyotype. Plasma levels of gonadotropins and testosterone were abnormally low.[ncbi.nlm.nih.gov] Tests include testosterone levels (low); follicle stimulating hormone and luteinizing hormone levels (elevated); X,Y karyotype; ultrasound or magnetic resonance imaging showing[bionity.com] Testicular biopsy is rarely indicated (special fixative required).[rcpa.edu.au]

  • Gonadoblastoma

    Most cases develop in women who have an abnormal karyotype in which at least a portion of the centromeric region of the short arm of chromosome Y is present, a region often[ncbi.nlm.nih.gov] Serum testing revealed primary hypogonadism pattern, elevated follicle-stimulating hormone and luteinizing hormone with low concentrations of estradiol and testosterone.[ncbi.nlm.nih.gov] Subsequent testicular biopsy and histopathological examination showed intratubular malignant germ cells in the testicular tubules.[ncbi.nlm.nih.gov]

  • XXXXY Syndrome

    The lack of a consistent karyotype abnormality associated with Peter's anomaly suggests that there are multiple genetic or environmental effects associated with its development[healio.com] They also have increased serum follicle-stimulating hormone and luteinizing hormone concentrations.[britannica.com] A testicular biopsy specimen showed defective germ cell and tubule development.[karger.com]

  • Male Pseudohermaphroditism

    […] cells, but no karyotypic abnormalities were found in peripheral blood lymphocytes or non-neoplastic kidney.[ncbi.nlm.nih.gov] The diagnosis is made biochemically by the presence of low testosterone and estradiol values with elevated luteinizing hormone levels in the absence of other significant hormonal[ncbi.nlm.nih.gov] However, in these male assigned patients, consideration must be given to the role of periodic testicular biopsies.[auajournals.org]

  • Germ Cell Tumor

    Abstract Klinefelter syndrome (KS) is a well-documented abnormality of the sex chromosome, with an incidence of 1 in 600 newborn males.[ncbi.nlm.nih.gov] Her serum hormonal assay revealed a low estradiol level with elevated luteinizing hormone and follicular stimulating hormone levels with normal progesterone and testosterone[ncbi.nlm.nih.gov] Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis[ncbi.nlm.nih.gov]

  • Oligospermia

    ‘In patients with azoospermia or severe oligospermia, the karyotype should be determined because of the increased incidence of karyotypic abnormalities in this population.[oxforddictionaries.com] Identical twin brothers presented with oligospermia, small testes, normal male phenotypes, elevated serum luteinizing hormone levels, and normal or elevated serum testosterone[ncbi.nlm.nih.gov] Diagnosis : clinical examination, semen collection and analysis /- reproductive ultrasonography of the stallion, testicular biopsy if indicated.[vetstream.com]