Ketosis: Causes & Reasons

Possible Causes for Ketosis

Synonyms Acidosis, metabolic Alcohol induced ketoacidosis Alcoholic ketoacidosis Ketoacidosis due to acute alcohol intoxication Ketoacidosis due to acute alcoholic intoxication Ketosis [icd9data.com]

[…] tissues that is marked by sickly sweet breath, headache, nausea and vomiting, and visual disturbances and is usually a result of excessive acid production — compare alkalosis, ketosis [merriam-webster.com]

Causes: Metabolic Acidosis and Elevated Anion Gap (Mnemonic: "MUD PILERS") Methanol, Metformin Uremia Diabetic Ketoacidosis (DKA), Alcohol ic ketoacidosis or starvation ketosis [fpnotebook.com]

Diabetic Ketotic Coma

During ketosis, ketones can easily be detected in the urine. [docsopinion.com]

Is ketosis healthy? [medicalnewstoday.com]

You can start ketosis by fasting, too. [webmd.com]

Propionic Acidemia

Symptomatic cases present during metabolic decompensation with acidosis, ketosis, increased anion gap, hyperlactatemia, hyperglycinemia, hyperammonemia, hypoglycemia and cytopenias [orpha.net]

This disease causes metabolic acidosis, ketosis, vomiting, lethargy, cognitive reductions, and death. There is no cure for PA. [mayoclinic.pure.elsevier.com]

Acetone Poisoning

See also ketosis. ac·e·tone ( as'e-tōn ), A colorless, volatile, flammable liquid; extremely small amounts are found in normal urine, but larger quantities occur in the urine [medical-dictionary.thefreedictionary.com]

Different dietary patterns including prolonged fasting and high fat low carbohydrate dieting can produce ketosis in which acetone is formed in the body tissue. [uniassignment.com]

Isopropanol is the only toxic alcohol that causes ketosis without acidosis. [lifeinthefastlane.com]

Poorly Controlled Diabetes Mellitus

Patients seldom develop ketosis but often exhibit obesity. [icd10data.com]

When the kidney is no longer able to handle the excess ketones the patient develops ketosis. [medical-dictionary.thefreedictionary.com]

Long-term treatment of the disease emphasizes control of blood glucose levels to prevent the acute complications of ketosis and hyperglycemia. [mayomedicallaboratories.com]

Diabetic Ketoacidosis

You may have heard from your doctor that ketosis is a life-threatening condition. [eatingacademy.com]

They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com]

I find my brain is much sharper when I’m in ketosis. [diabetesdaily.com]

Tropical Pancreatitis

Tropical calcific pancreatitis is associated with neither HIV infection nor antiretroviral therapy and often leads to insulin-dependent, but ketosis-resistant, diabetes mellitus [nejm.org]

TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus [uniprot.org]

[…] resistant and negligible in a small sub-group (n = 5) who were ketosis prone. [ncbi.nlm.nih.gov]

Alcoholic Ketoacidosis

A diet very low in carbohydrates (such as bread) can lead to ketosis. [livescience.com]

They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com]

"Toxigenic and Metabolic Causes of Ketosis and Ketoacidotic Syndromes". Critical Care Clinics. 28 (4): 601–631. doi:10.1016/j.ccc.2012.07.001. [en.wikipedia.org]

Fructose-1,6-Bisphosphatase Deficiency

Regardless of the onset of symptoms, lactic acidosis and ketosis may be life-threatening. For this reason, an early diagnosis can be life-saving. [symptoma.com]

Hypoglycaemia was accompanied by markedly raised levels of plasma free fatty acids, without the expected degree of ketosis. [discovery.ucl.ac.uk]

The disorder is manifested by the appearance of hypoglycaemia, ketosis and lactic acidosis (neonatally or later during fasting or induced by fructose) and may also be life-threatening [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 1C

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

Fasting hypoglycemia occurs with ketosis and appears early in life (infancy to childhood). [quizlet.com]

Acidosis without ketosis in biotin-unresponsive 3-methylcrotonyl-CoA carboxylase deficiency. [pedclerk.bsd.uchicago.edu]

Glycogen Storage Disease Type 0

Thus, glycogen storage disorders can manifest as hypoglycemia, ketosis, lethargy, fatigue, weakness, muscle cramping, and exercise intolerance. [emedicine.com]

Specific biochemical features : Hypoglycaemia, ketosis, raised fasting lactate. [patient.info]

Background Glycogen-storage disease type 0 (GSD-0), or glycogen synthetase deficiency, commonly appears in infancy and early childhood with fasting hypoglycemia accompanied by ketosis [emedicine.com]

Multiple Carboxylase Deficiency

A 30-month-old female patient who presented with the initial features of diabetic ketoacidosis (severe metabolic acidosis, ketosis, and hyperglycemia), lactic acidemia, moderate [ncbi.nlm.nih.gov]

[…] resulting in hypoglycemia • abnormal urine organic acids characteristic of ketosis increased lactic acid.  3-hydroxy isovaleric acid.  3-methylcrotonylglycine.  methylcitrate [fr.slideshare.net]

• accumulations of (ketone bodies) in tissues to excessive breakdown of fats resulting in ketosis • inhibits the urea cycle resulting in hyperammonemia. • inhibits gluconeogenesis [fr.slideshare.net]

Glycogen Storage Disease Type 6

During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov]

Symptoms - Glycogen storage disease type 6- due to phosphorylation Some of the symptoms of Glycogen storage disease type VI, due to phosphorylation incude: * Enlarged liver * Ketosis [checkorphan.org]

Because liver cells cannot break down glycogen into glucose, individuals with GSDVI can have hypoglycemia and may use fats for energy, resulting in ketosis. [ghr.nlm.nih.gov]

Muscle Phosphorylase Kinase Deficiency

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

When hypoglycemia or ketosis is present, Polycose ® or fruit juice is given orally as tolerated or glucose by IV. [ncbi.nlm.nih.gov]

During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov]

Glycogen Storage Disease Type 3

Symptoms improve after puberty but the increased metabolism of pregnancy predisposes to hypoglycaemia, ketosis and lactic acidosis. [ncbi.nlm.nih.gov]

Euglycemia needs to be maintained during pregnancy as lipolysis and ketosis increase the risk of fetal demise (1). [air.unimi.it]

Specific biochemical features : Hypoglycaemia, ketosis, raised fasting lactate. [patient.info]

Glycogen Storage Disease Type 9

The ketosis was reversed by glucagon administration. [ncbi.nlm.nih.gov]

While minimal hypoglycemia was occurring, prominent ketosis was present. [ncbi.nlm.nih.gov]

Mild hypoglycaemia, marked ketosis and insufficient growth hormone secretion were revealed at night. [ncbi.nlm.nih.gov]

Organic Aciduria

All these four disorders present in neonates as a neurologic distress of the intoxication type with either ketosis or ketoacidosis and hyperammonaemia. [ncbi.nlm.nih.gov]

[…] metabolic acidosis, low bicarbonate values, increased anion gap, hyperammonemia, hypoglycemia, lactic acidemia, triglyceridemia, elevated levels of free fatty acids, and ketosis [research.njms.rutgers.edu]

A clinical presentation of a metabolic disorder, often first seen in infants who present with poor feeding, vomiting, tachypnea, acidosis, hyperammonemia, ketosis, ketonuria [journals.sbmu.ac.ir]

Phosphoglycerate Kinase 1 Deficiency

Liver involvement ( liver GSD ): Types 0a, I, III, IV, VI, IX, GLUT 2 deficiency Hypoglycemia (typically fasting hypoglycemia ) and ketosis Hepatomegaly → distended abdomen [amboss.com]

[…] but normal resting serum lactate and uric acid Cori's disease lab data Cori's disease clinical sever hypoglycemia, ketosis, hepato(nephro)megaly increased # of short outer [quia.com]

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

Classic Maple Syrup Urine Disease

Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net]

Metabolic consequences include: Increased ketoacids -> ketosis, metabolic acidosis Increased glucose utilization -> ketosis Increased leucine -> brain toxicity Acute Presentation [newenglandconsortium.org]

In infants, ketosis, with the absence of significant metabolic acidosis, hyperammonaemia and hypoglycaemia, rules out many inborn errors of metabolism. [orpha.net]

Intermittent Maple Syrup Urine Disease

Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net]

If MSUD is found, there will be signs of ketosis and excess acid (acidosis). These are measured in the usual newborn screening test. [secure.ssa.gov]

GLUT1 Deficiency Syndrome

Ketone levels are checked daily to ensure ketosis is established. [epilepsy.com]

RESULTS: All patients reached mild to moderate ketosis and experienced remarkable improvement in the frequency and severity of paroxysmal movement disorders. [ncbi.nlm.nih.gov]

Benefits of these novel diets are increased palatability, practicability, and thus compliance-at the expense of lower ketosis. [ncbi.nlm.nih.gov]

Vomiting of Pregnancy

Hyperemesis gravidarum is uncontrollable vomiting during pregnancy that results in dehydration, weight loss, and ketosis. [merckmanuals.com]

Hyperemesis gravidarum is less common but is severe, leading to dehydration, ketosis, and weight loss. Consider nonobstetric causes of nausea and vomiting. [msdmanuals.com]

It can be distinguished because it causes the following: Weight loss ( > 5% of weight) Dehydration Ketosis Electrolyte abnormalities (in many women) Hyperemesis gravidarum [merckmanuals.com]

Methyl Ethyl Ketone Poisoning

A rare form of intoxication: acute methyl ethyl ketone peroxide poisoning Cece Sun et al. J Int Med Res. 2022 Jan. Free PMC article Abstract We report two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. A woman in her late 60s suffered from oral mucosal erosion, functional impairment of the[…] [pubmed.ncbi.nlm.nih.gov]

Infantile-Onset Pompe Disease

[…] of pathologies with similar clinical presentations to IoPD Disorder Key biochemical findings Elevated CK Elevated LDH Elevated transaminases Hypoglycaemia Lactic acidosis Ketosis [ncbi.nlm.nih.gov]

Disorders of Pyruvate Metabolism and Gluconeogenesis

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

Acidosis without ketosis in biotin-unresponsive 3-methylcrotonyl-CoA carboxylase deficiency. [pedclerk.bsd.uchicago.edu]

Atkin Syndrome

When the body is in ketosis, you tend to feel less hungry, and thus you're likely to eat less than you might otherwise. [medicinenet.com]

Ketosis All individuals exhibited urinary ketosis as determined by the ketostick test, with values ranging from +2 to +3 in the morning before breakfast, although that of [onlinelibrary.wiley.com]

Outcome Measures : Tic frequency [ Time Frame: 2 months ] Number of tics per day, intensity, severity, will be compared to baseline (pre-diet) Secondary Outcome Measures : Ketosis [clinicaltrials.gov]

HMG-CoA Lyase Deficiency

The disease is characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis, hypoglycemia, lethargy, hepatomegaly, and seizures. [ncbi.nlm.nih.gov]

Thus, patients present with severe and potentially life-threatening hypoglycemia, metabolic acidosis without ketosis, hyperammonemia, and even coma when introduced to dietary [symptoma.com]

Biochemically there is a characteristic absence of ketosis with hypoglycemia, acidosis, hipertransaminasemia and variable hyperammoniemia. [neurologia.com]

Transient Hyperammonemia of the Newborn

Urea cycle defect NO ketosis or acidosis!! [brainscape.com]

Organic acidemias Usually these disorders are associated with ketosis and acidosis in addition to hyperammonemia. [bredagenetics.com]

Urinary ketone tests: ketosis indicates an organic acidemia Plasma and urinary organic acid tests: These levels screen for an organic acidemia 77. [slideshare.net]

Disorder of Fatty Acid Metabolism

HMGCS2D should be considered in the differential diagnosis when hypertriglyceridemia, or low HDL cholesterol levels are seen in a child who presents with acidosis, mild ketosis [mayoclinic.pure.elsevier.com]

Objective To identify the genetic causes and evaluate the phenotype of mitochondrial HMG‐CoA synthase deficiency in a pediatric patient with uncommon features that included ketosis [onlinelibrary.wiley.com]

Hyperglycinuria

The outstanding features of the syndrome are: onset in the neonatal period of episodes of vomiting, lethargy and ketosis; neutropenia; periodic thrombocytopenia; hypogammaglobulinemia [pediatrics.aappublications.org]

[…] pro·pi·on·ic·ac·i·de·mia (pro″pe on″ik as″ĭ deґme ə) 1. an autosomal recessive aminoacidopathy characterized by an 2. excess of propionic acid in the blood and urine, with ketosis [medicine.academic.ru]

[…] development of late multiorgan complications of these diseases. (19342984, 21329767) Clinical synopsis The features of propionic acidemia are episodic vomiting, lethargy and ketosis [humpath.com]