Ketosis: Causes & Reasons

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Possible Causes for Ketosis

Acidosis

Synonyms Acidosis, metabolic Alcohol induced ketoacidosis Alcoholic ketoacidosis Ketoacidosis due to acute alcohol intoxication Ketoacidosis due to acute alcoholic intoxication Ketosis [icd9data.com]

[…] tissues that is marked by sickly sweet breath, headache, nausea and vomiting, and visual disturbances and is usually a result of excessive acid production — compare alkalosis, ketosis [merriam-webster.com]

Causes: Metabolic Acidosis and Elevated Anion Gap (Mnemonic: "MUD PILERS") Methanol, Metformin Uremia Diabetic Ketoacidosis (DKA), Alcohol ic ketoacidosis or starvation ketosis [fpnotebook.com]

Diabetic Ketotic Coma

A diet very low in carbohydrates (such as bread) can lead to ketosis. [livescience.com]

During ketosis, ketones can easily be detected in the urine. [docsopinion.com]

Is ketosis healthy? [medicalnewstoday.com]

Propionic Acidemia

This disease causes metabolic acidosis, ketosis, vomiting, lethargy, cognitive reductions, and death. There is no cure for PA. [mayoclinic.pure.elsevier.com]

In this case, ancillary testing showed ketosis and further workup showed presence of propionic acidemia in a 3-day-old neonate. [ncbi.nlm.nih.gov]

This disease causes metabolic acidosis, ketosis, vomiting, lethargy, mental retardation and death. [mayo.edu]

Acetone Poisoning

See also ketosis. ac·e·tone ( as'e-tōn ), A colorless, volatile, flammable liquid; extremely small amounts are found in normal urine, but larger quantities occur in the urine [medical-dictionary.thefreedictionary.com]

Different dietary patterns including prolonged fasting and high fat low carbohydrate dieting can produce ketosis in which acetone is formed in the body tissue. [uniassignment.com]

Isopropanol is the only toxic alcohol that causes ketosis without acidosis. [lifeinthefastlane.com]

Poorly Controlled Diabetes Mellitus

Patients seldom develop ketosis but often exhibit obesity. [icd10data.com]

When the kidney is no longer able to handle the excess ketones the patient develops ketosis. [medical-dictionary.thefreedictionary.com]

Long-term treatment of the disease emphasizes control of blood glucose levels to prevent the acute complications of ketosis and hyperglycemia. [mayomedicallaboratories.com]

Diabetic Ketoacidosis

They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com]

I find my brain is much sharper when I’m in ketosis. [diabetesdaily.com]

Triggers for ketosis A low-carbohydrate diet can trigger ketosis. [healthline.com]

Tropical Pancreatitis

Tropical calcific pancreatitis is associated with neither HIV infection nor antiretroviral therapy and often leads to insulin-dependent, but ketosis-resistant, diabetes mellitus [nejm.org]

About 25% of patients develop diabetes which generally requires insulin for its control but is ketosis-resistant. [ncbi.nlm.nih.gov]

TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus [uniprot.org]

Alcoholic Ketoacidosis

A diet very low in carbohydrates (such as bread) can lead to ketosis. [livescience.com]

They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com]

"Toxigenic and Metabolic Causes of Ketosis and Ketoacidotic Syndromes". Critical Care Clinics. 28 (4): 601–631. doi:10.1016/j.ccc.2012.07.001. [en.wikipedia.org]

Fructose-1,6-Bisphosphatase Deficiency

Regardless of the onset of symptoms, lactic acidosis and ketosis may be life-threatening. For this reason, an early diagnosis can be life-saving. [symptoma.com]

Hypoglycaemia was accompanied by markedly raised levels of plasma free fatty acids, without the expected degree of ketosis. [discovery.ucl.ac.uk]

The disorder is manifested by the appearance of hypoglycaemia, ketosis and lactic acidosis (neonatally or later during fasting or induced by fructose) and may also be life-threatening [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 0

Thus, glycogen storage disorders can manifest as hypoglycemia, ketosis, lethargy, fatigue, weakness, muscle cramping, and exercise intolerance. [emedicine.com]

Specific biochemical features : Hypoglycaemia, ketosis, raised fasting lactate. [patient.info]

Background Glycogen-storage disease type 0 (GSD-0), or glycogen synthetase deficiency, commonly appears in infancy and early childhood with fasting hypoglycemia accompanied by ketosis [emedicine.com]

Glycogen Storage Disease Type 6

During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov]

Moreover, ketosis may occur as a result of longer fasts (notably overnight) or vigorous physical activity. Some cases experience no hypoglycemia at all. [symptoma.com]

Because liver cells cannot break down glycogen into glucose, individuals with GSDVI can have hypoglycemia and may use fats for energy, resulting in ketosis. [ghr.nlm.nih.gov]

Muscle Phosphorylase Kinase Deficiency

When hypoglycemia or ketosis is present, Polycose ® or fruit juice is given orally as tolerated or glucose by IV. [ncbi.nlm.nih.gov]

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov]

Glycogen Storage Disease Type 9

The ketosis was reversed by glucagon administration. [ncbi.nlm.nih.gov]

While minimal hypoglycemia was occurring, prominent ketosis was present. [ncbi.nlm.nih.gov]

Mild hypoglycaemia, marked ketosis and insufficient growth hormone secretion were revealed at night. [ncbi.nlm.nih.gov]

Glycogen Storage Disease Type 3

Euglycemia needs to be maintained during pregnancy as lipolysis and ketosis increase the risk of fetal demise (1). [air.unimi.it]

Symptoms improve after puberty but the increased metabolism of pregnancy predisposes to hypoglycaemia, ketosis and lactic acidosis. [ncbi.nlm.nih.gov]

Specific biochemical features : Hypoglycaemia, ketosis, raised fasting lactate. [patient.info]

Multiple Carboxylase Deficiency

Severe metabolic acidosis with ketosis and hyperammonemia. [accessanesthesiology.mhmedical.com]

A 30-month-old female patient who presented with the initial features of diabetic ketoacidosis (severe metabolic acidosis, ketosis, and hyperglycemia), lactic acidemia, moderate [ncbi.nlm.nih.gov]

[…] resulting in hypoglycemia • abnormal urine organic acids characteristic of ketosis increased lactic acid.  3-hydroxy isovaleric acid.  3-methylcrotonylglycine.  methylcitrate [fr.slideshare.net]

Organic Aciduria

All these four disorders present in neonates as a neurologic distress of the intoxication type with either ketosis or ketoacidosis and hyperammonaemia. [ncbi.nlm.nih.gov]

[…] metabolic acidosis, low bicarbonate values, increased anion gap, hyperammonemia, hypoglycemia, lactic acidemia, triglyceridemia, elevated levels of free fatty acids, and ketosis [research.njms.rutgers.edu]

A clinical presentation of a metabolic disorder, often first seen in infants who present with poor feeding, vomiting, tachypnea, acidosis, hyperammonemia, ketosis, ketonuria [journals.sbmu.ac.ir]

Glycogen Storage Disease Type 1C

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

Fasting hypoglycemia occurs with ketosis and appears early in life (infancy to childhood). [quizlet.com]

Acidosis without ketosis in biotin-unresponsive 3-methylcrotonyl-CoA carboxylase deficiency. [pedclerk.bsd.uchicago.edu]

Classic Maple Syrup Urine Disease

Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net]

Metabolic consequences include: Increased ketoacids -> ketosis, metabolic acidosis Increased glucose utilization -> ketosis Increased leucine -> brain toxicity Acute Presentation [newenglandconsortium.org]

In infants, ketosis, with the absence of significant metabolic acidosis, hyperammonaemia and hypoglycaemia, rules out many inborn errors of metabolism. [orpha.net]

Phosphoglycerate Kinase 1 Deficiency

[…] but normal resting serum lactate and uric acid Cori's disease lab data Cori's disease clinical sever hypoglycemia, ketosis, hepato(nephro)megaly increased # of short outer [quia.com]

Liver involvement ( liver GSD ): Types 0a, I, III, IV, VI, IX, GLUT 2 deficiency Hypoglycemia (typically fasting hypoglycemia ) and ketosis Hepatomegaly → distended abdomen [amboss.com]

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

Intermittent Maple Syrup Urine Disease

Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net]

If MSUD is found, there will be signs of ketosis and excess acid (acidosis). These are measured in the usual newborn screening test. [secure.ssa.gov]

Methyl Ethyl Ketone Poisoning

Journal List J Int Med Res v.50(1); 2022 Jan PMC8743954 J Int Med Res. 2022 Jan; 50(1): 03000605211067694. Cece Sun,1 Tianzi Jian,1 Yaqian Li,1 Siqi Cui,1,2 Longke Shi,1,2 Guangcai Yu,1 Baotian Kan,3,4 and Xiangdong Jian1 Abstract We report two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. A woman[…] [ncbi.nlm.nih.gov]

Transient Hyperammonemia of the Newborn

Urea cycle defect NO ketosis or acidosis!! [brainscape.com]

Urinary ketone tests: ketosis indicates an organic acidemia Plasma and urinary organic acid tests: These levels screen for an organic acidemia 77. [slideshare.net]

Organic acidemias Usually these disorders are associated with ketosis and acidosis in addition to hyperammonemia. [bredagenetics.com]

Disorders of Pyruvate Metabolism and Gluconeogenesis

Acidosis without ketosis in biotin-unresponsive 3-methylcrotonyl-CoA carboxylase deficiency. [pedclerk.bsd.uchicago.edu]

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

HMG-CoA Lyase Deficiency

The disease is characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis, hypoglycemia, lethargy, hepatomegaly, and seizures. [ncbi.nlm.nih.gov]

Thus, patients present with severe and potentially life-threatening hypoglycemia, metabolic acidosis without ketosis, hyperammonemia, and even coma when introduced to dietary [symptoma.com]

[…] methylglutaryl-CoA lyase (HL) deficiency is a rare autosomal recessive genetic disorder characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis [genome.jp]

Hyperglycinuria

The outstanding features of the syndrome are: onset in the neonatal period of episodes of vomiting, lethargy and ketosis; neutropenia; periodic thrombocytopenia; hypogammaglobulinemia [pediatrics.aappublications.org]

[…] pro·pi·on·ic·ac·i·de·mia (pro″pe on″ik as″ĭ deґme ə) 1. an autosomal recessive aminoacidopathy characterized by an 2. excess of propionic acid in the blood and urine, with ketosis [medicine.academic.ru]

Hartnup Disease (Sensitivity to light and eye defect) Homocystinuria (Mental retardation) 3-hydroxy-3-methylglutaryl-CoA-lyase deficiency (Severe metabolic acidosis without ketosis [genetics-tests.com]

Vomiting of Pregnancy

Hyperemesis gravidarum is uncontrollable vomiting during pregnancy that results in dehydration, weight loss, and ketosis. [merckmanuals.com]

[…] gravidarum is nausea and vomiting severe enough to cause physiological and biochemical effects, including significant dehydration, often with electrolyte abnormalities, ketosis [sharinginhealth.ca]

Then the body breaks down fats, resulting in a buildup of waste products (ketones) called ketosis. Ketosis can cause fatigue, bad breath, dizziness, and other symptoms. [merckmanuals.com]

Maple Syrup Urine Disease Mild Variant

If MSUD is found, there will be signs of ketosis and excess acid (acidosis). These are measured in the usual newborn screening test. [secure.ssa.gov]

[…] and mental retardation completely preventable; since acute decompensation by BCAA and BCKA is due to a breakdown of endogenous proteins resulting in metabolic acidosis, ketosis [medical-dictionary.thefreedictionary.com]

Disorder of Fatty Acid Metabolism

HMGCS2D should be considered in the differential diagnosis when hypertriglyceridemia, or low HDL cholesterol levels are seen in a child who presents with acidosis, mild ketosis [ncbi.nlm.nih.gov]

Objective To identify the genetic causes and evaluate the phenotype of mitochondrial HMG‐CoA synthase deficiency in a pediatric patient with uncommon features that included ketosis [onlinelibrary.wiley.com]

Maple Syrup Urine Disease

Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net]

If MSUD is found, there will be signs of ketosis and excess acid (acidosis). These are measured in the usual newborn screening test. [secure.ssa.gov]

Glycogen Storage Disease Type 10

[…] but normal resting serum lactate and uric acid Cori's disease lab data Cori's disease clinical sever hypoglycemia, ketosis, hepato(nephro)megaly increased # of short outer [quia.com]

Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com]

 GSD 0 presents in infancy or early childhood with fasting hypoglycemia and ketosis and, in contrast, with postprandial hyperglycemia and hyperlactatemia.  Treatment is [slideshare.net]