Possible Causes for ketosis Acidosis Synonyms Acidosis, metabolic Alcohol induced ketoacidosis Alcoholic ketoacidosis Ketoacidosis due to acute alcohol intoxication Ketoacidosis due to acute alcoholic intoxication Ketosis [icd9data.com] […] tissues that is marked by sickly sweet breath, headache, nausea and vomiting, and visual disturbances and is usually a result of excessive acid production — compare alkalosis, ketosis [merriam-webster.com] Causes: Metabolic Acidosis and Elevated Anion Gap (Mnemonic: "MUD PILERS") Methanol, Metformin Uremia Diabetic Ketoacidosis (DKA), Alcohol ic ketoacidosis or starvation ketosis [fpnotebook.com] Diabetic Ketotic Coma During ketosis, ketones can easily be detected in the urine. [docsopinion.com] A diet very low in carbohydrates (such as bread) can lead to ketosis. [livescience.com] Is ketosis healthy? [medicalnewstoday.com] Diabetic Ketoacidosis This particular presentation of diabetes has been termed as ketosis-prone type 2 diabetes (KPDM) or atypical diabetes. [ncbi.nlm.nih.gov] They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com] Subsequent studies evaluated phosphate and bicarbonate therapy, lipid metabolism, ketosis-prone type 2 patients, and use of rapid-acting insulin analogs as well as leptin [ncbi.nlm.nih.gov] Propionic Acidemia In this case, ancillary testing showed ketosis and further workup showed presence of propionic acidemia in a 3-day-old neonate. [ncbi.nlm.nih.gov] The findings of elevated glycine levels associated with ketosis prompted the diagnosis of propionic acidemia. [ncbi.nlm.nih.gov] This disease causes metabolic acidosis, ketosis, vomiting, lethargy, mental retardation, and death. [web.archive.org] Acetone Poisoning See also ketosis. ac·e·tone ( as'e-tōn ), A colorless, volatile, flammable liquid; extremely small amounts are found in normal urine, but larger quantities occur in the urine [medical-dictionary.thefreedictionary.com] Different dietary patterns including prolonged fasting and high fat low carbohydrate dieting can produce ketosis in which acetone is formed in the body tissue. [uniassignment.com] Isopropanol is the only toxic alcohol that causes ketosis without acidosis. [lifeinthefastlane.com] Tropical Pancreatitis Tropical calcific pancreatitis is associated with neither HIV infection nor antiretroviral therapy and often leads to insulin-dependent, but ketosis-resistant, diabetes mellitus [nejm.org] TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus [uniprot.org] Vomiting of Pregnancy […] gravidarum is nausea and vomiting severe enough to cause physiological and biochemical effects, including significant dehydration, often with electrolyte abnormalities, ketosis [sharinginhealth.ca] Complications In severe cases, dehydration, weight loss, electrolyte disturbance (eg, ketosis) and nutritional deficiency can occur. [patient.info] Hyperemesis gravidarum is uncontrollable vomiting during pregnancy that results in dehydration, weight loss, and ketosis. [merckmanuals.com] Alcoholic Ketoacidosis A diet very low in carbohydrates (such as bread) can lead to ketosis. [livescience.com] "Toxigenic and Metabolic Causes of Ketosis and Ketoacidotic Syndromes". Critical Care Clinics. 28 (4): 601–631. doi:10.1016/j.ccc.2012.07.001. [en.wikipedia.org] They will then tell you that ketosis is dangerous. [ketogenic-diet-resource.com] Fructose-1,6-Diphosphatase Deficiency The disorder is manifested by the appearance of hypoglycaemia, ketosis and lactic acidosis (neonatally or later during fasting or induced by fructose) and may also be life-threatening [ncbi.nlm.nih.gov] Hypoglycaemia was accompanied by markedly raised levels of plasma free fatty acids, without the expected degree of ketosis. [discovery.ucl.ac.uk] […] experience hypoglycemia and metabolic acidosis on fasting, episodes of hyperventilation, suspension of breathing (apnea), and elevated levels of ketones in their blood (ketosis [rarediseases.info.nih.gov] Glycogen Storage Disease Type 9 The ketosis was reversed by glucagon administration. [ncbi.nlm.nih.gov] While minimal hypoglycemia was occurring, prominent ketosis was present. [ncbi.nlm.nih.gov] Mild hypoglycaemia, marked ketosis and insufficient growth hormone secretion were revealed at night. [ncbi.nlm.nih.gov] Glycogen Storage Disease Type 6 During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov] Symptoms - Glycogen storage disease type 6- due to phosphorylation Some of the symptoms of Glycogen storage disease type VI, due to phosphorylation incude: * Enlarged liver * Ketosis [checkorphan.org] Because liver cells cannot break down glycogen into glucose, individuals with GSDVI can have hypoglycemia and may use fats for energy, resulting in ketosis. [ghr.nlm.nih.gov] Glycogen Storage Disease Type 3 Symptoms improve after puberty but the increased metabolism of pregnancy predisposes to hypoglycaemia, ketosis and lactic acidosis. [ncbi.nlm.nih.gov] Euglycemia needs to be maintained during pregnancy as lipolysis and ketosis increase the risk of fetal demise (1). [air.unimi.it] They use fat mostly as an energy source and this leads to lipemia, acidemia and ketosis. d. There is fatty infiltration of the liver. e. [biologydiscussion.com] Glycogen Storage Disease Type 0 Thus, glycogen storage disorders can manifest as hypoglycemia, ketosis, lethargy, fatigue, weakness, muscle cramping, and exercise intolerance. [emedicine.com] Patients typically have hypoglycemia and ketosis, with lactate and alanine levels in the low or normal part of the reference range approximately 5–7 hours after fasting. [en.wikipedia.org] Background Glycogen-storage disease type 0 (GSD-0), or glycogen synthetase deficiency, commonly appears in infancy and early childhood with fasting hypoglycemia accompanied by ketosis [emedicine.com] Multiple Carboxylase Deficiency A 30-month-old female patient who presented with the initial features of diabetic ketoacidosis (severe metabolic acidosis, ketosis, and hyperglycemia), lactic acidemia, moderate [ncbi.nlm.nih.gov] Severe metabolic acidosis with ketosis and hyperammonemia. [accessanesthesiology.mhmedical.com] […] resulting in hypoglycemia • abnormal urine organic acids characteristic of ketosis increased lactic acid. 3-hydroxy isovaleric acid. 3-methylcrotonylglycine. methylcitrate [fr.slideshare.net] Inadequate Diet Harik, S.I. (1996) Diet-induced ketosis does not cause cerebral acidosis. [scindeks.ceon.rs] Neurology, 21(11): 1097-103 [ CR ] [ PM ] [ EČ ][ GS ] Likhodii, S.S., Musa, K., Mendonca, A., Dell, C., Burnham, W.M., Cunnane, S.C. (2000) Dietary fat, ketosis, and seizure [scindeks.ceon.rs] Organic Aciduria All these four disorders present in neonates as a neurologic distress of the intoxication type with either ketosis or ketoacidosis and hyperammonaemia. [ncbi.nlm.nih.gov] […] metabolic acidosis, low bicarbonate values, increased anion gap, hyperammonemia, hypoglycemia, lactic acidemia, triglyceridemia, elevated levels of free fatty acids, and ketosis [research.njms.rutgers.edu] […] of the laboratory performing the test. Neonates do not normally produce much acetoacetate, ketosis detected in neonates by dipstick should prompt serious consideration [slideshare.net] Glycogen Storage Disease due to Muscle Phosphorylase Kinase Deficiency When hypoglycemia or ketosis is present, Polycose or fruit juice is given orally as tolerated or glucose by IV. [ncbi.nlm.nih.gov] Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com] During prolonged periods without food (fasting), affected individuals may have low blood sugar (hypoglycemia) or elevated levels of ketones in the blood (ketosis). [ghr.nlm.nih.gov] Diabetes Mellitus "Essential labile diabetes" is an insulin-dependent diabetes, in the course of which irregular and unpredictable hyperglycemias, frequently with ketosis, and sometimes serious [ncbi.nlm.nih.gov] Users of insulin pumps, by virtue of absent reservoirs of subcutaneous insulin, may present with ketosis and more normal blood glucose levels. [emedicine.medscape.com] Diabetic ketoacidosis Diabetic ketoacidosis (DKA) is much less common than hypoglycemia but is potentially far more serious, creating a life-threatening medical emergency. [13] Ketosis [emedicine.medscape.com] GLUT1 Deficiency Syndrome Ketone levels are checked daily to ensure ketosis is established. [epilepsy.com] Benefits of these novel diets are increased palatability, practicability, and thus compliance-at the expense of lower ketosis. [ncbi.nlm.nih.gov] RESULTS: All patients reached mild to moderate ketosis and experienced remarkable improvement in the frequency and severity of paroxysmal movement disorders. [ncbi.nlm.nih.gov] Methyl Ethyl Ketone Poisoning Mohamed Salah Shirazy * and Akram Muhammed Fayed Department of Critical Care Medicine, Faculty of Medicine, University of Alexandria *Corresponding Author: Mohamed Salah Shirazy 11 Atlas street El Asafra Alexandria, Egypt Tel: 201113880033 E-mail: [email protected] Received date: May 11, 2015 Accepted date: June 22,[…] [omicsonline.org] Classic Maple Syrup Urine Disease Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net] Metabolic consequences include: Increased ketoacids - ketosis, metabolic acidosis Increased glucose utilization - ketosis Increased leucine - brain toxicity Acute Presentation [newenglandconsortium.org] In infants, ketosis, with the absence of significant metabolic acidosis, hyperammonaemia and hypoglycaemia, rules out many inborn errors of metabolism. [orpha.net] Glycogen Storage Disease due to Glucose-6-Phosphat Transport Defect Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com] Fasting hypoglycemia occurs with ketosis and appears early in life (infancy to childhood). [quizlet.com] Acidosis without ketosis in biotin-unresponsive 3-methylcrotonyl-CoA carboxylase deficiency. [pedclerk.bsd.uchicago.edu] Glycogen Storage Disease due to Phosphoglycerate Kinase 1 Deficiency […] but normal resting serum lactate and uric acid Cori's disease lab data Cori's disease clinical sever hypoglycemia, ketosis, hepato(nephro)megaly increased # of short outer [quia.com] Liver involvement ( liver GSD ): Types 0a, I, III, IV, VI, IX, GLUT 2 deficiency Hypoglycemia (typically fasting hypoglycemia ) and ketosis Hepatomegaly distended abdomen [amboss.com] Frequency: Rare Onset: Early childhood Clinical features: Benign course with symptoms lessening with aging; growth retardation, hepatomegaly, hypoglycemia, hyperlipidemia, ketosis [msdmanuals.com] HMG-CoA Lyase Deficiency The disease is characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis, hypoglycemia, lethargy, hepatomegaly, and seizures. [ncbi.nlm.nih.gov] […] methylglutaryl-CoA lyase (HL) deficiency is a rare autosomal recessive genetic disorder characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis [genome.jp] Typically, severely affected patients present in the first year of life with hypoglycemic crisis without ketosis. [ncbi.nlm.nih.gov] Intermittent Maple Syrup Urine Disease Metabolic consequences include: Increased ketoacids - ketosis, metabolic acidosis Increased glucose utilization - ketosis Increased leucine - brain toxicity Acute Presentation [newenglandconsortium.org] Otherwise, isolated ketosis and encephalopathy or maple syrup odor are suggestive. [orpha.net] If MSUD is found, there will be signs of ketosis and excess acid (acidosis). These are measured in the usual newborn screening test. [secure.ssa.gov] Hyperuricemia During starvation (or total fasting) as the step 4 of weight reduction diet, an extreme metabolic alteration takes place, which is characterized by ketosis. [ncbi.nlm.nih.gov] […] enzyme abnormalities Causes for decreased urate excretion Drugs Renal HTN, polycystic kidney disease, chronic renal failure Metabolic/endocrine Dehydration, lactic acidosis, ketosis [quizlet.com] Decreased tubular secretion of urate occurs in patients with acidosis (eg, diabetic ketoacidosis, ethanol or salicylate intoxication, starvation ketosis). [emedicine.com] 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency HMGCS2D should be considered in the differential diagnosis when hypertriglyceridemia, or low HDL cholesterol levels are seen in a child who presents with acidosis, mild ketosis [ncbi.nlm.nih.gov] Objective To identify the genetic causes and evaluate the phenotype of mitochondrial HMG‐CoA synthase deficiency in a pediatric patient with uncommon features that included ketosis [onlinelibrary.wiley.com] Insulin Resistance Delayed development, severe insulin resistance, mild hyperglycemia, absence of ketosis, and remarkable response of hyperinsulinemia and hyperglycemia to pioglitazone which [ncbi.nlm.nih.gov] A 27-yr-old African woman with ketosis-prone diabetes and HIV infection developed severe insulin resistance after the initiation of HAART. [ncbi.nlm.nih.gov] His plan, which I began to follow, is 0-50 carbs per day ketosis (when your brain is fueled by ketones); 50-100 carbs per day weight loss; and 100-150 carbs per day maintenance [goodmenproject.com] Diabetic Angiopathy […] can occur last stages of chronic complications are present, ketosis is common 30. [slideshare.net] Insulin Signalling, Action and Secretion - Diabetic 2020 (Finland) Insulin Therapy - Endocrinology-CS-2020 (Italy) Ketogenic Diet for Diabetes - Euro Diabetes 2020 (Spain) Ketosis [diabetes.conferenceseries.com] Pathogenetic and clinical difference of type I and type II DM N Signs Type 1 Type 2 2 Beginning of disease Acute Gradual 3 Duration Labile Stable 4 Ketosis, ketoacidosis Often [slideshare.net] Hyperglycinuria The outstanding features of the syndrome are: onset in the neonatal period of episodes of vomiting, lethargy and ketosis; neutropenia; periodic thrombocytopenia; hypogammaglobulinemia [pediatrics.aappublications.org] […] pro·pi·on·ic·ac·i·de·mia (pro″pe on″ik as″ĭ deґme ə) 1. an autosomal recessive aminoacidopathy characterized by an 2. excess of propionic acid in the blood and urine, with ketosis [medicine.academic.ru] Hartnup Disease (Sensitivity to light and eye defect) Homocystinuria (Mental retardation) 3-hydroxy-3-methylglutaryl-CoA-lyase deficiency (Severe metabolic acidosis without ketosis [genetics-tests.com]
