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15 Possible Causes for Lacrimal Gland Enlargement, Malaise, T-Lymphocyte Count Increased

  • Infectious Mononucleosis

    A 16-year-old, previously healthy girl presents with a several-day history of fever, sore throat, and malaise. She appears very tired and has a temperature of 39 C.[doi.org]

  • Precursor-Cell Lymphoblastic Leukemia

    The increase in the ALC was primarily from activated CTL019 T lymphocytes. Patient 1 was a 7-year-old girl with a second recurrence of ALL.[doi.org] They largely reflect bone marrow failure and include malaise, fatigue, bleeding or bruising, and secondary infections.[accessmedicine.mhmedical.com] […] fatigue (including ‘malaise’ and ‘malaise/fatigue’) and infections (including ‘infection’ and ‘recurrent infections’).[adc.bmj.com]

  • Influenza

    Deterioration of CD4 T-lymphocyte cell counts or progression of HIV disease has not been demonstrated among HIV-infected persons after influenza vaccination compared with[cdc.gov] […] influenza A virus has accounted for the majority of influenza infections in the 2017 to 2018 flu season, with the typical clinical presentation including fever, myalgias, malaise[ncbi.nlm.nih.gov] […] cytokines in human beings now helps to explain some of the symptoms of colds and flu that were previously in the realm of folklore rather than medicine-eg, fever, anorexia, malaise[ncbi.nlm.nih.gov]

  • Herpes Zoster

    Most studies have documented increasing zoster risk as CD4 T-lymphocyte counts decline, but the risk is increased nine-fold even among HIV-infected women with CD4 T-lymphocyte[web.archive.org] The typical clinical manifestation is an acute segmental eruption of herpetiform umbilicated vesicles associated with malaise, pain, dysaesthesia, allodynia and probably fever[ncbi.nlm.nih.gov] In the initial stage of herpes zoster (ie, prodromal phase), patients may experience headache, pain, malaise, and acute photophobia before the rash appears.[jaoa.org]

  • Acute Lymphoblastic Leukemia 

    Systemic Involvement Pathologic basis for the clinical manifestations of leukemia Presentation Cause anemia, pallor, fatigue, malaise, hypoxia, bleeding rapidly proliferating[physio-pedia.com] […] most common presenting symptoms are due to disrupted hematopoiesis with ensuing Anemia Thrombocytopenia Granulocytopenia Anemia can manifest with fatigue, weakness, pallor, malaise[msdmanuals.com] […] shortness of breath, light-headedness, palpitations Infections – due to lack of normal white blood cells Infections are more frequent, more severe and last longer Fever, malaise[leukaemiacare.org.uk]

  • Mikulicz Disease

    It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Mikulicz disease comprises the triad of: symmetrical enlargement of all salivary glands narrowing of the palpebral fissures due to enlargement of the lacrimal glands parchment-like[gpnotebook.co.uk] The first symptoms may further include malaise, loss of appetite and a low-grade temperature that rises quickly within the first 24 hours.[symptoma.com]

  • Waldenstrom Macroglobulinemia

    Additional tests that may be done include: 24-hour urine protein Total protein Immunofixation in urine T (thymus derived) lymphocyte count Bone x-rays Some people with WM[nlm.nih.gov] A 71-year-old woman presented with malaise, skin bruising, epistaxis, and gingival bleeding of recent and prompt onset. There was no adenopathy.[ncbi.nlm.nih.gov] He went to the Hospital because of malaise, asthenia, diarrhea and nausea in the last five months.[revistanefrologia.com]

  • Alcoholic Hepatitis

    B and T lymphocytes are noted in the portal and periportal areas, and natural killer lymphocytes are noted around hyalin-containing hepatocytes.[emedicine.medscape.com] Physical Examination and Laboratory Findings In Alcoholic Liver Disease Physical Examination Constitutional Fever Skin Spider angioma Parotid and lacrimal gland enlargement[clevelandclinicmeded.com] […] circulation Bone Rib fractures on CXR Spinal osteoporosis (particularly in men) Generally, patients with fatty liver have few symptoms, however they may notice nausea and malaise[almostadoctor.co.uk]

  • IgG4-Related Retroperitoneal Fibrosis

    It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Most commonly involved are the pancreas, major salivary glands (sialadenitis, salivary gland enlargement), lacrimal glands (lacrimal gland enlargement and proptosis), retroperitoneal[elynsgroup.com] ., fever, malaise, weight loss, flank pain, etc.). Bilateral ureteral obstruction, with subsequent hydronephrosis and obstructive nephropathy, is common.[amboss.com]

  • Chronic Thyroiditis

    It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Lacrimal gland enlargement was observed in 8 cases.[ajnr.org] Patients with multicentric CD often complain of systemic manifestations, such as fever, night sweats, malaise, and weight loss.[hematologyandoncology.net]