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65 Possible Causes for Lactate Decreased, Persistent Lactic Acidosis

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[] Blood lactate and pyruvate concentration decreased by 50% within three days and 24 h urine lactate content within 2 weeks and we observed a clinical improvement together with[] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[]

  • Acidosis

    Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis , whereas lactic acidosis is characterized[] The patient's lactate level decreased about 2 weeks after discharge.[] Symptoms of Lactic Acidosis The symptoms of lactic acidosis include: Persistent nausea, vomiting, and abdominal (belly) pain Unexplained tiredness Shortness of breath Rapid[]

  • Cardiogenic Shock

    lactic acidosis, low cardiac output, high doses of catecholamines, kidney and/or liver failure) and of cardiac arrest without “no flow” in patients with advanced chronic[] RESULTS: At 24 h, lactate decreased from 3.2 (2.1-6.8) to 1.8 (1.2-2.2) mmol/L (p 0.001).[] Active MCS significantly increased MAP (MD 11.85 mmHg, 95% CI 3.39 to 20.31, P   0.02, I2   32.7%) and decreased arterial lactate (MD - 1.36 mmol/L, 95% CI - 2.52 to - 0.19[]

  • Septic Shock

    acidosis, persistent, oliguria, low BP and a narrow PP, tachycardia, and skin/extremity findings of low flow.[] […] in the blood Decreased capillary filling or mottling Medical Disclaimer The information on or available through this site is intended for educational purposes only.[] These abnormalities may lead to cellular dysfunction, lactic acidosis and, ultimately, multiorgan failure.[]

  • Glycogen Storage Disease Type 1

    In the present case, an acidification test was omitted because the patient had a past history of severe lactic acidosis.[] Intracerebral ratios of glucose and lactate to creatine were higher in GSD1 patients (P 0.05 vs. control).[] In individuals suffering from GSD type 1, serum glucose and blood pH levels are often decreased but the cholesterol levels, triglyceride, serum lactate and uric acid are elevated[]

  • Lactic Acidosis

    […] interval: 2.5-20.6; P CONCLUSION: In the absence of risk factors associated with persistent lactic acidosis, such as shock or acute kidney or liver injury, continued peri-operative[] TMP/SMX was discontinued and the lactate decreased to 2.9 mmol/L within 24 hours while her plasma bicarbonates normalized, without additional intervention.[] lactic acidosis CAUSES (Cohen & Woods classification) Type A – Inadequate Oxygen Delivery anaerobic muscular activity (sprinting, generalised convulsions) tissue hypoperfusion[]

  • Hypoglycemia

    During hypoglycemia, brain lactate decreased 30% below baseline in patients with IAH but returned to baseline levels and remained there in the other two groups.[] […] of alternative carbon fuels such as lactate or ketones.[] At the beginning of hypoglycemia (after HIIT), brain lactate levels were elevated in all groups but most pronounced in patients with IAH.[]

  • Maple Syrup Urine Disease Mild Variant

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[] Dehydrogenase Isoenzyme Electrophoresis 3-methyl-2-oxobutanoate dehydrogenase According to the submitter, biochemical test results for this subject showed decreased enzyme[] Development of persistent lactic acidosis occurs between 8 weeks and 6 months of age Followed by progressive neurologic deterioration with - Hypotonia Developmental delay[]

  • Sepsis

    However, in patients with persistently elevated lactate without evidence of inadequate oxygen delivery, type B lactic acidosis should be considered.[] Compared to all other treatment, norepinephrine was not associated with decreased lactate levels at the first measuring point.[] Hypoperfusion abnormalities may include lactic acidosis, oliguria, or an acute alteration in mental status.[]

  • Cardiomyopathy

    acidosis, severe lactic acidosis, expansion and hypertrophic cardiomyopathy.[] […] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species. 43,44 D CM has been described in the setting of transient neonatal[] Met452Val) in a female infant who presented with poor sucking at birth, poor activity, hyporeflexia, hypertonia, persistent pulmonary hypertension of newborn (PPHN), metabolic[]

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