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65 Possible Causes for Lactate Decreased, Persistent Lactic Acidosis

  • MELAS Syndrome

    MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms.[ncbi.nlm.nih.gov] Blood lactate and pyruvate concentration decreased by 50% within three days and 24 h urine lactate content within 2 weeks and we observed a clinical improvement together with[ncbi.nlm.nih.gov] There is persistent lactic acidosis. Histologically, there are ragged red fibres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle.[omicsonline.org]

  • Acidosis

    Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis , whereas lactic acidosis is characterized[emedicine.medscape.com] The patient's lactate level decreased about 2 weeks after discharge.[nature.com] Symptoms of Lactic Acidosis The symptoms of lactic acidosis include: Persistent nausea, vomiting, and abdominal (belly) pain Unexplained tiredness Shortness of breath Rapid[thebody.com]

  • Cardiogenic Shock

    lactic acidosis, low cardiac output, high doses of catecholamines, kidney and/or liver failure) and of cardiac arrest without “no flow” in patients with advanced chronic[annalsofintensivecare.springeropen.com] RESULTS: At 24 h, lactate decreased from 3.2 (2.1-6.8) to 1.8 (1.2-2.2) mmol/L (p 0.001).[ncbi.nlm.nih.gov] Active MCS significantly increased MAP (MD 11.85 mmHg, 95% CI 3.39 to 20.31, P   0.02, I2   32.7%) and decreased arterial lactate (MD - 1.36 mmol/L, 95% CI - 2.52 to - 0.19[ncbi.nlm.nih.gov]

  • Septic Shock

    acidosis, persistent, oliguria, low BP and a narrow PP, tachycardia, and skin/extremity findings of low flow.[clinicaladvisor.com] […] in the blood Decreased capillary filling or mottling Medical Disclaimer The information on or available through this site is intended for educational purposes only.[sepsis.org] These abnormalities may lead to cellular dysfunction, lactic acidosis and, ultimately, multiorgan failure.[enotes.tripod.com]

  • Glycogen Storage Disease Type 1

    In the present case, an acidification test was omitted because the patient had a past history of severe lactic acidosis.[academic.oup.com] Intracerebral ratios of glucose and lactate to creatine were higher in GSD1 patients (P 0.05 vs. control).[ncbi.nlm.nih.gov] In individuals suffering from GSD type 1, serum glucose and blood pH levels are often decreased but the cholesterol levels, triglyceride, serum lactate and uric acid are elevated[symptoma.com]

  • Lactic Acidosis

    […] interval: 2.5-20.6; P CONCLUSION: In the absence of risk factors associated with persistent lactic acidosis, such as shock or acute kidney or liver injury, continued peri-operative[ncbi.nlm.nih.gov] TMP/SMX was discontinued and the lactate decreased to 2.9 mmol/L within 24 hours while her plasma bicarbonates normalized, without additional intervention.[ncbi.nlm.nih.gov] lactic acidosis CAUSES (Cohen & Woods classification) Type A – Inadequate Oxygen Delivery anaerobic muscular activity (sprinting, generalised convulsions) tissue hypoperfusion[lifeinthefastlane.com]

  • Hypoglycemia

    During hypoglycemia, brain lactate decreased 30% below baseline in patients with IAH but returned to baseline levels and remained there in the other two groups.[ncbi.nlm.nih.gov] […] of alternative carbon fuels such as lactate or ketones.[doi.org] At the beginning of hypoglycemia (after HIIT), brain lactate levels were elevated in all groups but most pronounced in patients with IAH.[ncbi.nlm.nih.gov]

  • Maple Syrup Urine Disease Mild Variant

    Between 2 and 6 months of age, persistent lactic acidosis starts to develop. References: MSUD Family Support Group, 2010. MSUD Classifications. [online].[maplesyrupstory.blogspot.com] Dehydrogenase Isoenzyme Electrophoresis 3-methyl-2-oxobutanoate dehydrogenase According to the submitter, biochemical test results for this subject showed decreased enzyme[catalog.coriell.org] Development of persistent lactic acidosis occurs between 8 weeks and 6 months of age Followed by progressive neurologic deterioration with - Hypotonia Developmental delay[motherbabyuniversity.com]

  • Sepsis

    However, in patients with persistently elevated lactate without evidence of inadequate oxygen delivery, type B lactic acidosis should be considered.[ncbi.nlm.nih.gov] Compared to all other treatment, norepinephrine was not associated with decreased lactate levels at the first measuring point.[doi.org] Hypoperfusion abnormalities may include lactic acidosis, oliguria, or an acute alteration in mental status.[doi.org]

  • Cardiomyopathy

    acidosis, severe lactic acidosis, expansion and hypertrophic cardiomyopathy.[ncbi.nlm.nih.gov] […] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species. 43,44 D CM has been described in the setting of transient neonatal[revportcardiol.org] Met452Val) in a female infant who presented with poor sucking at birth, poor activity, hyporeflexia, hypertonia, persistent pulmonary hypertension of newborn (PPHN), metabolic[ncbi.nlm.nih.gov]

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