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40 Possible Causes for Lactate Dehydrogenase Increased, Muscle Twitch, Spasticity - Hyperreflexia

  • Amyotrophic Lateral Sclerosis

    For example, NSC-34 cells treated with CSF from patients with ALS exhibited decreased cell viability and increased lactate dehydrogenase activity [ 48 ], suggesting that factors[doi.org] The upper motor signs include spasticity, hyperreflexia and weakness. The lower motor signs include amyotrophy, weakness and fasciculations.[symptoma.com] twitching for 3 years.[ncbi.nlm.nih.gov]

  • Progressive Muscular Atrophy

    Clinical Loss of fine motor skills, triad of atrophic weakness of hands and forearms; leg spasticity; generalised hyperreflexia. Management Possibly riluzole.[medical-dictionary.thefreedictionary.com] This then leads to fasciculations (muscle twitches), progressively worsening muscle weakness, and a loss of muscle mass and weight.[mndcentre.org.uk] However, hyperreflexia and spasticity typical of ALS never occur in MMN. Conduction block Amount of block increases with more proximal stimulation. B.[neuromuscular.wustl.edu]

  • Bone Metastasis

    Spinal cord compression at the level of the cervical or thoracic spine can cause hyperreflexia and spasticity with complete paraplegia.[ncbi.nlm.nih.gov] Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.[xgeva.com]

  • Scorpion Sting

    This condition is characterized by microangiopathic hemolytic anemia, thrombocytopenia, increased serum levels of lactate dehydrogenase and uremia.[ncbi.nlm.nih.gov] There was a right facial nerve palsy (upper motor neuron type); right spastic hemiplegia with hyperreflexia and extensor plantar response. Fundoscopy was unremarkable.[atmph.org] Common symptoms of a scorpion sting include: pain, tingling or burning sensation at the sting site malaise, sweating, nausea and vomiting salivating numbness muscle twitching[desertusa.com]

  • Hyponatremia

    Serum α-fetoprotein, β-HCG, and lactate dehydrogenase were highly elevated. Urine sodium and osmolality were increased.[ncbi.nlm.nih.gov] They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[aafp.org] As hyponatremia becomes more severe, muscle twitching and seizures may occur.[merckmanuals.com]

  • Distal Spinal Muscular Atrophy Type 3

    Blood investigations revealed normal creatinine phosphokinase and lactate dehydrogenase.[cags.org.ae] , weakness and hyperreflexia where the progressive bulbar involvement causes bulbar symptoms such as dysarthria and dysphagia.[2],[3].[explainmedicine.com] […] may include: Tremor of the hands Muscle cramps when performing physical activities Muscle twitches and weakness of limb muscles As the condition progresses: Weakness of the[thehumanthebody.com]

  • X-linked Parkinsonism-Spasticity Syndrome

    Ragged red fibers can be found on muscle biopsy with increased succinic dehydrogenase activity and cytochrome oxidase negative fibers in almost 90% of cases.[neuroweb.us] […] abnormalities on examination of patients with pure HSP include spasticity, hyperreflexia, and extensor plantar responses, with weakness of a pyramidal distribution in the[jnnp.bmj.com] Myoclonus: Shock-like, arrhythmic twitches. Not suppressible.[stanfordmedicine25.stanford.edu]

  • Olivopontocerebellar Atrophy

    Ischemic exercise failed to increase the blood ammonia, while lactate increased normally.[ncbi.nlm.nih.gov] However, this symptomatic component does not own a subtype. [4] Signs of corticospinal tract dysfunction (hyperreflexia, impaired muscle performance, spasticity, and a positive[physio-pedia.com] twitching during voluntary activation (facial action myoclonus).[ncbi.nlm.nih.gov]

  • Juvenile Huntington Disease

    […] depletion, increased lactate concentration, and neuronal loss in the striatum.[emedicine.medscape.com] Except for Chorea, other symptoms include eye-movement abnormalities, parkinsonism, dystonia, myoclonus, tics, ataxia, dysarthria and dysphagia, and spasticity with hyperreflexia[bmcneurol.biomedcentral.com] The child may develop seemingly minor movement disorders, such as slowness, rigidity, tremor, or rapid muscle twitching.[healthcommunities.com]

  • Proximal Myopathy with Extrapyramidal Signs

    Frequency not reported : ALT increased, AST increased Postmarketing reports : Cholestatic hepatitis, cholestasis, jaundice, alkaline phosphatase increased, blood lactate[drugs.com] The essential clinical findings are slowly progressive and often include severe spasticity, hyperreflexia, and weakness in a pyramidal distribution, noticeably in both lower[emedicine.medscape.com] Other symptoms include hypotension, tachycardia, hypothermia, miosis, tremor, muscle twitching, spasm, rigidity or hypotonia, convulsions, difficulty in swallowing and breathing[mentalhealth.com]

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