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12 Possible Causes for Lactate Dehydrogenase Increased, Pancytopenia, Polyclonal Hyperglobulinemia

  • Primary Myelofibrosis

    The latter was associated more frequently with anaemia, thrombocytopenia, peripheral blood blasts and increased lactate dehydrogenase levels.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] Abstract An HIV positive black African woman presented with widespread lymphadenopathy and pancytopenia that had been ascribed to tuberculosis.[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • Angioimmunoblastic Lymphadenopathy

    dehydrogenase (LDH) level (commonly increased) Polyclonal gamma globulins (common) Anemia with hemoglobin with values below 10 g/dL can be present, and a direct Coombs test[emedicine.medscape.com] Laboratory findings included progressive pancytopenia, hyperuricemia, and acute renal failure. Bone marrow biopsy showed a T cell lymphoid neoplasm that had ...[citeulike.org] Eosinophilia and hypergammaglobulinemia were not found whereas C-reactive protein, lactate dehydrogenase, β2-microglobulin and serum immunoglobulins were increased.[diagnosticpathology.biomedcentral.com]

  • Idiopathic Cryoglobulinemia

    . • However, a high rate of hematologic side effects (mainly grade 3 and 4 pancytopenia) was recorded. 1. Saadoun D, et al.[slideshare.net] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] […] polymorphonuclear neutrophils ( D71 ) human immunodeficiency virus [HIV] disease ( B20 ) D89 Other disorders involving the immune mechanism, not elsewhere classified Excludes1 hyperglobulinemia[icd10coded.com]

  • Anemia due to Glutathione Metabolism Disorder

    Total and unconjugated bilirubin : levels are increased due to increased RBC destruction Serum lactate dehydrogenase (LDH) level : increased Serum haptoglobin level : decreased[medcaretips.com] Excludes1: pancytopenia (due to) (with): aplastic anemia (D61.-) bone marrow infiltration (D61.82) congenital (pure) red cell aplasia (D61.01) drug induced (D61.1) hairy[en.wikisource.org] Pyruvate Dehydrogenase Deficiency Autosomal Recessive. Pyruvate Dehydrogenase deficiency ------ buildup of lactate and pyruvate ------ lactic acidosis.[kumc.edu]

  • Congenital Intrinsic Factor Deficiency

    Serum bilirubin level of the unconjugated type may be slightly elevated and the serum lactate dehydrogenase is usually increased, often dramatically.[basicmedicalkey.com] Gene GIF (AR) Diagnostic Test Plasma Vitamin B12, Folate Neurological Ataxia, dystonia Non-Neurological Megaloblastic anemia, pancytopenia Treatment HydroxyCobalamin Level[treatable-id.org] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • Posthemorrhagic Anaemia of the Newborn

    (urine)\n","Pyoderma gangrenosum\n","Raynaud's phenomenon\n","Lactate dehydrogenase levels raised (plasma or serum)\n","Uric acid levels raised (plasma or serum)\n\nSource[webhealthnetwork.com] […] with malformations 284.1 Pancytopenia Excludes: pancytopenia (due to) (with): aplastic anemia NOS (284.9) bone marrow infiltration (284.2) constitutional red blood cell aplasia[theodora.com] NOS (R77.1) monoclonal gammopathy (of undetermined significance) (D47.2) Excludes2: transplant failure and rejection (T86.-) D89.0 Polyclonal hypergammaglobulinemia Benign[en.wikisource.org]

  • MALT Lymphoma

    Nodal involvement ( 5% of cases), systemic symptoms (1%), increased lactate dehydrogenase serum levels (1%) and non-conjunctival sites are considered negative prognostic factors[infectagentscancer.biomedcentral.com] In the entire collective, three cases (6%) of prolonged pancytopenia including manifest myelodysplastic syndrome in one patient (2%), three cases (6%) of secondary lymphoid[ncbi.nlm.nih.gov] Not only MALT lymphoma, but also SjS can cause secondary hyperglobulinemia. Indeed, immunoelectrophoresis-serum test showed a polyclonal pattern of hyperglobulinemia.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    Biochemical evidence of haemolysis was supported by serum decresead haptoglobin level, increased indirect bilirubin and lactate dehydrogenase levels.[casereports.bmj.com] […] lymphoproliferative syndrome (ALPS) is a rare, newly recognized, chronic lymphoproliferative disorder in children and is characterized by lymphadenopathy, splenomegaly, pancytopenia[ncbi.nlm.nih.gov] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com]

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