Create issue ticket

294 Possible Causes for Lactate Dehydrogenase Increased, Pancytopenia, Splenomegaly

  • Primary Myelofibrosis

    The latter was associated more frequently with anaemia, thrombocytopenia, peripheral blood blasts and increased lactate dehydrogenase levels.[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    […] numbers of eosinophils and basophils Differential WCC shows granulocytes at all stages of development Anaemia (normocytic/normochromic) Biochemistry: Lactate dehydrogenase[geekymedics.com] Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Lactate dehydrogenase (LDH) is usually normal.[clinicaladvisor.com] Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    […] chemicals measured in blood tests , for example lactate dehydrogenase (LDH) or calcium.[lymphoma-action.org.uk] In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Fatigue, generalized lymphadenopathy and splenomegaly are its typical features.[symptoma.com] A baseline F-FDG PET/CT scan in a patient with mantle cell lymphoma showed diffuse minimally FDG-avid lymphadenopathy and splenomegaly.[ncbi.nlm.nih.gov] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[ncbi.nlm.nih.gov]

  • Leukemia

    CT, MRI, or abdominal ultrasonography may help assess splenomegaly or leukemic infiltration of other organs.[merckmanuals.com] […] fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly Splenomegaly[symptoma.com] […] familial exposure to radiation during cancer treatment and strategies to help limit incidental contact with potentially harmful byproducts. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[ncbi.nlm.nih.gov] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Acute Leukemia

    Symptoms include splenomegaly, monocytosis with granulocytosis, and thrombocytopenia. leukemia cu tis leukemia with leukocytic invasion of the skin marked by pink, reddish[medical-dictionary.thefreedictionary.com] Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com]

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Furthermore, it may inhibit three-lineage haematopoiesis in the bone marrow, causing severe pancytopenia.[ncbi.nlm.nih.gov]

Similar symptoms