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166 Possible Causes for Lactate Dehydrogenase Increased, Progressive Muscle Weakness

  • Duchenne Muscular Dystrophy

    Occasionally, an increased alanine aminotransferase, aspartate aminotransferase, or lactate dehydrogenase concentration prompts an inappropriate focus on hepatic dysfunction[ncbi.nlm.nih.gov] DMD leads to progressive muscle weakness, degeneration, and wasting; finally, follows with the premature demise in affected individuals due to respiratory and/or cardiac failure[ncbi.nlm.nih.gov] Abstract Because of the progressive muscle weakness they experience, patients with Duchenne muscular dystrophy frequently utilize positive-pressure devices to maintain adequate[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 2

    dehydrogenase are increased in most patients with PD but may occasionally be within normal limits in those with adult-onset PD. 34 Muscle biopsies for primary diagnostic[dx.doi.org] It is characterized by delayed motor skills (such as rolling over and sitting) and progressive muscle weakness.[ghr.nlm.nih.gov] Serum enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), or lactate dehydrogenase (LDH) may be elevated and may reflect enzymes released from[dx.doi.org]

  • Progressive Muscular Atrophy

    This results in progressive muscle weakness, fasciculations (rippling effect under the skin), and shrinkage in muscle bulk and weight loss.[umcutrecht.nl] Symptoms The main sign of muscular dystrophy is progressive muscle weakness.[mayoclinic.org] This then leads to fasciculations (muscle twitches), progressively worsening muscle weakness, and a loss of muscle mass and weight.[mndcentre.org.uk]

  • Dermatomyositis

    PATIENT CONCERNS: A 71-year-old Japanese woman was admitted to the rheumatology department of another hospital with progressive muscle weakness of the limbs and erythema on[ncbi.nlm.nih.gov] The cardinal symptom is a skin rash that precedes, accompanies, or follows progressive muscle weakness.[patientslikeme.com] Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness[patientslikeme.com]

  • Polymyositis

    Weakness occurs when at least 50% of muscle cells become damaged, so the patient experiences progressive muscle weakness spanning three to six months.[symptoma.com] In rare cases individuals with severe and progressive muscle weakness will develop respiratory failure or pneumonia.[myositis.yolasite.com] Some may only experience brief muscle weakness followed by recovery with no need for more treatment, while others may experience prolonged and progressive muscle weakness[symptoma.com]

  • Amyotrophic Lateral Sclerosis

    For example, NSC-34 cells treated with CSF from patients with ALS exhibited decreased cell viability and increased lactate dehydrogenase activity [ 48 ], suggesting that factors[doi.org] Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is a neurodegenerative disease that results in progressive muscle weakness and wasting.[ncbi.nlm.nih.gov] Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, compromising the motor neuron, characterized by progressive muscle weakness, with reserved prognosis.[ncbi.nlm.nih.gov]

  • Myopathy

    The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[ncbi.nlm.nih.gov] HIBM causes progressive muscle weakness and wasting.[hibm.org] We describe a 41-year-old male with HIV infection who presented progressive proximal muscle weakness and limb-girdle atrophy.[ncbi.nlm.nih.gov]

  • Non-Hodgkin Lymphoma

    Most of the aggressive lymphomas present with a rapidly growing tumor mass, fever, night sweats, weight loss, and increased levels of serum lactate dehydrogenase and uric[symptoma.com] PATIENT CONCERNS: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities.[ncbi.nlm.nih.gov] One indicator of the potential for tumor lysis syndrome is an elevated plasma lactate dehydrogenase level or hyperuricemia at the time of diagnosis.[emedicine.com]

  • Carcinoma of the Prostate

    This may cause weakness or low strength. Progressive weight-bearing exercise help improve strength. Osteoporosis (loss of bone mineral density).[urologyhealth.org] Less oxygen gets to tissues and organs, causing tiredness or weakness. It can be treated with medicines, vitamins and minerals. Loss of muscle mass.[urologyhealth.org]

  • Glycogen Storage Disease Type 1

    The incresased levels of pyruvate lead to increased lactate produciton via lactate dehydrogenase (LDH) and alanine via alanine transaminase (ALT).[themedicalbiochemistrypage.org] The build-up of glycogen causes progressive muscle weakness ( myopathy ) throughout the body and affects various tissues, particularly the heart, skeletal muscles, liver,[snpedia.com] Glycogen storage disease type II involves progressive muscle weakness in the trunk, lower limbs, and diaphragm.[path.upmc.edu]

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