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166 Possible Causes for Lactate Dehydrogenase Increased, Progressive Muscle Weakness

  • Duchenne Muscular Dystrophy

    Occasionally, an increased alanine aminotransferase, aspartate aminotransferase, or lactate dehydrogenase concentration prompts an inappropriate focus on hepatic dysfunction[] DMD leads to progressive muscle weakness, degeneration, and wasting; finally, follows with the premature demise in affected individuals due to respiratory and/or cardiac failure[] Abstract Because of the progressive muscle weakness they experience, patients with Duchenne muscular dystrophy frequently utilize positive-pressure devices to maintain adequate[]

  • Glycogen Storage Disease Type 2

    dehydrogenase are increased in most patients with PD but may occasionally be within normal limits in those with adult-onset PD. 34 Muscle biopsies for primary diagnostic[] It is characterized by delayed motor skills (such as rolling over and sitting) and progressive muscle weakness.[] Serum enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), or lactate dehydrogenase (LDH) may be elevated and may reflect enzymes released from[]

  • Progressive Muscular Atrophy

    This results in progressive muscle weakness, fasciculations (rippling effect under the skin), and shrinkage in muscle bulk and weight loss.[] Symptoms The main sign of muscular dystrophy is progressive muscle weakness.[] This then leads to fasciculations (muscle twitches), progressively worsening muscle weakness, and a loss of muscle mass and weight.[]

  • Dermatomyositis

    PATIENT CONCERNS: A 71-year-old Japanese woman was admitted to the rheumatology department of another hospital with progressive muscle weakness of the limbs and erythema on[] The cardinal symptom is a skin rash that precedes, accompanies, or follows progressive muscle weakness.[] Dermatomyositis is one of a group of muscle diseases known as the inflammatory myopathies, which are characterized by chronic muscle inflammation accompanied by muscle weakness[]

  • Polymyositis

    Weakness occurs when at least 50% of muscle cells become damaged, so the patient experiences progressive muscle weakness spanning three to six months.[] In rare cases individuals with severe and progressive muscle weakness will develop respiratory failure or pneumonia.[] Some may only experience brief muscle weakness followed by recovery with no need for more treatment, while others may experience prolonged and progressive muscle weakness[]

  • Amyotrophic Lateral Sclerosis

    For example, NSC-34 cells treated with CSF from patients with ALS exhibited decreased cell viability and increased lactate dehydrogenase activity [ 48 ], suggesting that factors[] Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is a neurodegenerative disease that results in progressive muscle weakness and wasting.[] Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, compromising the motor neuron, characterized by progressive muscle weakness, with reserved prognosis.[]

  • Myopathy

    The laboratory evaluation was remarkable for the marked increase in the serum lactate dehydrogenase and creatine phosphokinase levels.[] HIBM causes progressive muscle weakness and wasting.[] We describe a 41-year-old male with HIV infection who presented progressive proximal muscle weakness and limb-girdle atrophy.[]

  • Non-Hodgkin Lymphoma

    Most of the aggressive lymphomas present with a rapidly growing tumor mass, fever, night sweats, weight loss, and increased levels of serum lactate dehydrogenase and uric[] PATIENT CONCERNS: The patient presented with a 5-month history of muscle weakness, progressive body aches, and weakness and numbness in both lower extremities.[] One indicator of the potential for tumor lysis syndrome is an elevated plasma lactate dehydrogenase level or hyperuricemia at the time of diagnosis.[]

  • Carcinoma of the Prostate

    This may cause weakness or low strength. Progressive weight-bearing exercise help improve strength. Osteoporosis (loss of bone mineral density).[] Less oxygen gets to tissues and organs, causing tiredness or weakness. It can be treated with medicines, vitamins and minerals. Loss of muscle mass.[]

  • Glycogen Storage Disease Type 1

    The incresased levels of pyruvate lead to increased lactate produciton via lactate dehydrogenase (LDH) and alanine via alanine transaminase (ALT).[] The build-up of glycogen causes progressive muscle weakness ( myopathy ) throughout the body and affects various tissues, particularly the heart, skeletal muscles, liver,[] Glycogen storage disease type II involves progressive muscle weakness in the trunk, lower limbs, and diaphragm.[]

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