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17 Possible Causes for Lactate Dehydrogenase Increased, Supraclavicular Adenopathy

  • Gastric Cancer

    Increased lactate within GC TILs was positively correlated with increased lactate dehydrogenase A (LDH)A.[] Other possible signs of metastatic disease include left supraclavicular adenopathy (Virchow's node), periumbilical node (Sister Mary Joseph nodule), and an anterior axillary[] Lactate was significantly increased in GC TILs and related to decreased T helper (Th)1 cells and cytotoxic T lymphocytes (CTLs).[]

  • Childhood Hodgkin's Disease

    The presence of bulky disease, suggested by increased lactate dehydrogenase, signals a poor prognosis.[] Adenopathies are most often asymmetrical. Signs of profound lymph node enlargement, such as those described in the superior vena cava syndrome should be also looked for.[] Further useful biochemical tests include alkaline phosphatase, whose increased levels signals bony metastasis, as well as complete liver and kidney function assessment, keeping[]

  • T-Cell Lymphoblastic Lymphoma

    The disease has a poorer outlook if the following factors are present: Age ( 30-40) Increased level of an enzyme called lactate dehydrogenase (LDH) Brain, spinal cord, bone[] Further staging studies revealed bulky adenopathy throughout the mesentery and retroperitoneum.[] Figure 2 A surgeon performed an excisional biopsy of a left supraclavicular node, which was consistent with T-cell lymphoblastic lymphoma: diffuse proliferation of intermediate[]

  • Non-Hodgkin Lymphoma

    Most of the aggressive lymphomas present with a rapidly growing tumor mass, fever, night sweats, weight loss, and increased levels of serum lactate dehydrogenase and uric[]

  • Squamous Cell Carcinoma of the Head and Neck

    A 65-year-old woman presented with a "sore bump" on her tongue. She had a history of squamous cell carcinoma of the head and neck that had been treated with surgery and radiotherapy 11 years earlier. The tongue lesion was excised, and pathologic examination identified a submucosal focus of benign-appearing[…][]

  • Renal Cell Carcinoma

    In addition, look for hypertension, supraclavicular adenopathy, and a flank or abdominal mass with bruit.[]

  • Gastric Adenocarcinoma

    A 73-year-old woman underwent upper endoscopic screening that revealed a 30-mm superficial elevated lesion in the anterior wall of the upper gastric body. The lesion had a whitish color and coarse granular surface in conventional white light endoscopy. Magnifying narrow-band imaging indicated irregular microvascular[…][]

  • Hodgkin's Disease

    We describe the case of a 59-year-old Caucasian male who presented to the outpatient clinic with intractable hiccups, upper abdominal pain, repeated bouts of vomiting, and stiff neck. Physical examination revealed a cachectic male with pallor, with enlarged left supraclavicular Virchow's lymph node and[…][]

  • Squamous Cell Carcinoma

    Increased serum lactate dehydrogenase (LDH) activity is considered as a marker of cellular necrosis while serum alkaline phosphatase (ALP) is recognized as an important marker[] Breast ultrasound showed a hypoechogenic tumor lesion of 4 cm in the right upper external quadrant that was associated with multiple axillary and infra-/supraclavicular adenopathies[]

  • Testicular Seminoma

    , multiple supraclavicular and left hilar adenopathy with pleural effusion, and extensive retroperitoneal adenopathy (Fig 3) encasing the aorta, inferior vena cava and peripancreatic[] Figure 1 Figure 1: Chest Xray- left lung white out CT scan of chest and abdomen revealed massive mediastinal adenopathy (Fig 2) extending into the thoracic inlet bilaterally[]

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