may be evaluated in the cerebrospinal fluid (CSF) together with lactate, both usually having increased values. … Biochemical findings, such as indirect markers of energy utilization, including lactate levels, should be investigated to identify the underlying defect, and levels of pyruvate … The diagnosis is made by obtaining levels of lactate and pyruvate in the cerebrospinal fluid through a lumbar puncture, while a magnetic resonance imaging SCAN (MRI) of the … 
ratio of D:L isomers as acidosis progresses. … In this situation, glycolysis is increased to provide additional ATP, and the excess pyruvate produced is converted into lactate and released from the cell into the bloodstream … Lactate production is buffered intracellularly, e.g. the lactate-producing enzyme, lactate dehydrogenase, binds one hydrogen cation per pyruvate molecule converted.
Another typical finding is increased blood lymphocytes of which more than 10% are atypical. … Liver function tests may reveal increase in serum transaminases, but such elevations can also be seen in patient with viral hepatitis. … Nevertheless, in an effort to decrease the risk of splenic rupture experts advise avoidance of contact sports and other heavy physical activity, especially when involving increased … 
CML is more common in males than in females (male to female ratio of 1.4:1) and appears more commonly in the elderly with a median age at diagnosis of 65 years. … In the accelerated phase, the number of abnormal blood cells increases. … In chronic myeloid leukemia the bone marrow makes a greatly increased numbers of abnormal blast cells.
In skeletal muscle fibers, a large transverse tubule system with a high surface-area to volume ratio exists. … intracellular Na+ in the cytosol of the muscle cell, increasing the activity of the Na+/K+-ATPase. … Another theory is that the few remaining functional chloride channels in muscle may become more active with increased muscle activity.
Distended jugular veins due to increased jugular venous pressure. … Head and Neck: Jugular venous distention may be evident due to the increased a cardiac compliance. … Some patients may require medications to increase blood flow through the heart and improve the heart pump muscles.