Lactate/Pyruvate Ratio Increased Causes & Reasons

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Lactate/Pyruvate Ratio Increased Symptom Checker: Possible causes include Panic Attacks. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Panic Attacks

The phenomenology of panic attacks and of complex partial seizures overlap, and at times distinguishing between the two entities is difficult. The authors report five patients with recurrent panic attacks and temporal lobe EEG abnormalities whose symptoms did not warrant a clinical diagnosis of partial seizures but[…] [ncbi.nlm.nih.gov]

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Leigh's Disease

Laboratory investigations revealed elevated blood lactate at rest (58 mg/dL; normal, 8–22 mg/dL) and increased lactate-pyruvate ratio (L/P 61.6; normal, 6–25). [ajnr.org]

In primary skin fibroblasts, the free cytosolic NAD /NADH ratio is coupled to the lactate/pyruvate (L/P) ratio8,18. [nature.com]

Compatible with the reductive stress idea, patients with CI deficiency displayed a mild/severe lactic acidemia paralleled by an increased L/P ratio in the corresponding skin [nature.com]

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Lactic Acidosis

Lactate is in equilibrium with pyruvate, anaerobic conditions increasing the normal 10:1 lactate:pyruvate ratio. [gpnotebook.co.uk]

This forces pyruvate to undergo anaerobic metabolism to lactate rather than entering the citric acid cycle. Here the lactate/pyruvate ratio is increased. [rc.rcjournal.com]

NAD This is a reversible reaction that favors lactate synthesis with the lactate-to-pyruvate ratio that is normally at 25:1. [emedicine.medscape.com]

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Acidosis

NAD This is a reversible reaction that favors lactate synthesis with the lactate-to-pyruvate ratio that is normally at 25:1. [emedicine.medscape.com]

[…] of protons to lactate. [sportsci.org]

Lactate synthesis increases when the rate of pyruvate formation in the cytosol exceeds its rate of use by the mitochondria. [emedicine.medscape.com]

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Traumatic Brain Injury

Lactate/pyruvate ratio correlated negatively with CMRO(2) (P 0.001), but not with OEF or CvO(2). [ncbi.nlm.nih.gov]

The increase in the ratio is comprised primarily of a reduction in the pyruvate concentration by 10- to 100-fold compared with increases in lactate by 2- to 5-fold ( Vespa [doi.org]

In the region of the MD probe, PET imaging revealed ischemia in a single patient despite increased LPR in other patients. [ncbi.nlm.nih.gov]

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Cardiomyopathy

[…] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species. 43,44 D CM has been described in the setting of transient neonatal [revportcardiol.org]

[…] defects can present as D CM, particularly in the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate [revportcardiol.org]

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Pyruvate Carboxylase Deficiency

Hyperlactacidemia was associated with dramatic increase in lactate/pyruvate ratio, without anoxia, in contrast with decreased beta hydroxybutyrate/acetoacetate ratio. [ncbi.nlm.nih.gov]

An increased lactate-to-pyruvate ratio is characteristic of citric acid cycle disorders. [emedicine.com]

[…] and pyruvate levels High blood lactate and pyruvate levels with or without lactic aciduria suggests an inborn error of energy metabolism. [emedicine.com]

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Chronic Fatigue Syndrome

Therefore, impaired energy generation in muscle, an increase in the lactate/pyruvate ratio in CFS/ME patients, and a propensity towards excess intramuscular acidosis following [hindawi.com]

[96] in an experimental exercise model using rats demonstrated that when PDC function was decreased via the use of PPAR modulating drugs which upregulated PDK function, lactate [hindawi.com]

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Brain Contusion

High level of lactate might be caused by hypoxia/ischemia, but increased glycolysis can also be. The lactate-pyruvate ratio distinguishes between these conditions. [scielo.br]

Pyruvate production falls during ischemia, which causes variations in the lactate-pyruvate ratio 3. [scielo.br]

Lactate and the lactate-pyruvate ratio relate to the extent of glycolysis and anaerobic metabolism. [scielo.br]

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Pallidopyramidal Syndrome

Laboratory investigations revealed elevated blood lactate at rest (58 mg/dL; normal, 8–22 mg/dL) and increased lactate-pyruvate ratio (L/P 61.6; normal, 6–25). [ajnr.org]

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Combined Oxidative Phosphorylation Defect Type 14

In mitochondrial disorders, unprocessed pyruvate is converted to lactate. Both, lactate and pyruvate are elevated, and the L/P ratio increases. [neuropathology-web.org]

Biochemically, there is profound lactic acidosis because the NADH:NAD ratio increases, shifting the equilibrium of the lactate dehydrogenase reaction toward lactate. [msdmanuals.com]

Therefore, an increase of ketone body (β-OH butyrate/acetoacetate) and lactate/pyruvate (L/P) molar ratios with secondary elevation of blood lactate might be found in the [ommbid.mhmedical.com]

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Dilated Cardiomyopathy

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Familial Isolated Dilated Cardiomyopathy

[…] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species.43,44 DCM has been described in the setting of transient neonatal [revportcardiol.org]

[…] defects can present as DCM, particularly in the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate [revportcardiol.org]

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Dilated Cardiomyopathy 1R

[…] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species.43,44 DCM has been described in the setting of transient neonatal [revportcardiol.org]

[…] defects can present as DCM, particularly in the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate [revportcardiol.org]

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Dilated Cardiomyopathy Type 2B

[…] and lactate/pyruvate ratio and decreased free carnitine with a relative increase in acylcarnitine species.43,44 DCM has been described in the setting of transient neonatal [revportcardiol.org]

[…] defects can present as DCM, particularly in the setting of multiorgan disease, thus warranting screening for lactic acidosis in these patients, who may present with elevated lactate [revportcardiol.org]

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Alcoholic Ketoacidosis

As patients recover and receive glucose and thiamine supplementation, ATP is made which reverses the pyruvate-to- lactate and NAD -to-NADH ratios. [emdocs.net]

The decreased ratio of NAD to NADH has the following implications: Impaired conversion of lactate to pyruvate with an increase in serum lactic acid levels Impaired gluconeogenesis [emedicine.com]

Increased lactate due to pyruvate shunting: Reduced caloric intake, decreased glycogen stores, and thiamine depletion results in amino acids being converted to pyruvate. [emdocs.net]

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Combined Oxidative Phosphorylation Defect Type 8

NAD This is a reversible reaction that favors lactate synthesis with the lactate-to-pyruvate ratio that is normally at 25:1. [emedicine.medscape.com]

In mitochondrial disorders, unprocessed pyruvate is converted to lactate. Both, lactate and pyruvate are elevated, and the L/P ratio increases. [neuropathology-web.org]

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Arthrogryposis Multiplex Congenita

Although her cerebrospinal fluid (CSF) levels of lactate and pyruvate were not increased, brain magnetic resonance spectroscopy showed a lactate peak. [ncbi.nlm.nih.gov]

Additionally, her CSF lactate/pyruvate and serum beta-hydroxybutyrate/acetoacetate ratios were high, and levels of oxidative phosphorylation in skin fibroblasts were reduced [ncbi.nlm.nih.gov]

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Sideroblastic Anemia

Increased lactate/pyruvate ratio is observed along with increased urinary excretion of lactate and related organic acids. [emedicine.medscape.com]

lactate/pyruvate ratio. [orpha.net]

[…] fibrotic exocrine pancreatic dysfunction with malabsorption and diarrhea, or a defect in oxidative phosphorylation resulting in lactic academia (sometimes intermittent) and an increased [orpha.net]

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Megaloblastic Anemia

Lactate levels in serum and the lactate/pyruvate ratio were increased. [ncbi.nlm.nih.gov]

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Retinohepatoendocrinologic Syndrome

Increased lactate/pyruvate ratio is observed along with increased urinary excretion of lactate and related organic acids. [emedicine.medscape.com]

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Alcohol-induced Hypoglycemia

Both of these two events lead to fatty acid deposition in the liver leading to fatty liver syndrome. 8) Increased [lactate]/[Pyruvate] ratio, results in hyperlacticacidemia [namrata.co]

The increase of the NADH/NAD ratio favors the metabolism of pyruvate to lactate; furthermore, the elimination of lactate depends mainly on the conversion of pyruvate to acetyl [nature.com]

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Drug-induced Hypokalemia

Metformin also inhibits complex I of the mitochondrial electron transport chain (ETC) 84 increases NADH/NAD ratio blocks the entry of pyruvate into the tricarboxylic acid [f1000research.com]

Metformin inhibits pyruvate carboxylase (PC) inhibits hepatic gluconeogenesis 146 excess lactate 84. [f1000research.com]

LDH lactate dehydrogenase 2. [f1000research.com]

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Phosphoenolpyruvate Carboxykinase Deficiency

[…] anion gap L/P: Lactate/pyruvate ratio, N: Normal, «: Decreased, ª: Increased, GSD I: glycogen storage disorder type I, FBP: fructose-1, 6-bisphosphatase deficiency, PEPCK [biology-online.org]

An increased lactate-to-pyruvate ratio is characteristic of citric acid cycle disorders. [emedicine.medscape.com]

insulin-like growth factor-1 (Click image to enlarge) Figure 3 Evaluation of metabolic acidosis (Click image to enlarge) Figure 4 Evaluation of metabolic acidosis with increased [biology-online.org]

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Hyperalaninemia

An increased lactate-to-pyruvate ratio is characteristic of citric acid cycle disorders. [emedicine.medscape.com]

[…] and pyruvate levels High blood lactate and pyruvate levels with or without lactic aciduria suggests an inborn error of energy metabolism. [emedicine.medscape.com]

Phosphoenolpyruvate carboxykinase deficiency 2-Ketoglutarate dehydrogenase deficiency Dihydrolipoamide dehydrogenase deficiency Fumarase deficiency Lab Studies and Histologic Findings Lactate [emedicine.medscape.com]

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Multiple Carboxylase Deficiency

These nonleucine pathway involvements produce: (1) lactic acidosis with an increased lactate-to-pyruvate ratio due to a defect in pyruvate metabolism, (2) propionic acidemia [pediatricneuro.com]

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MELAS Syndrome

Patients have increased lactate and pyruvate levels in serum and cerebrospinal fluid, and elevated lactate/pyruvate ratio. [dx.doi.org]

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Acute Tubular Necrosis

The kidney [1-(13)C]pyruvate/[1-(13)C]lactate ratio showed substantial variability and was not significantly decreased in animals with ATN or increased in animals with GN. [ncbi.nlm.nih.gov]

No such increase in renal [1,4-(13)C(2)]malate was observed in mice with acute GN. [ncbi.nlm.nih.gov]

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Huntington's Disease

Specifically, HD progression was seen to be associated with reduction in NAD and increase in lactate-to-pyruvate ratio. [ncbi.nlm.nih.gov]

Six out of the 35 metabolites analyzed, namely, nicotinamide adenine dinucleotide (NAD), lactate, pyruvate, succinate, sarcosine, and acetoin, displayed segregation with progressive [ncbi.nlm.nih.gov]

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Phenothiazine Poisoning

All MB-treated rats displayed a significant reduction in hyperlactacidemia, a restoration of pyruvate/lactate ratio - a marker of NAD/NADH ratio - and an increase in CO 2 [pennstate.pure.elsevier.com]

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