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400 Possible Causes for lactone, transport

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  • Upper Respiratory Infection

    […] in polarized primary human sinonasal cells, we demonstrate that T2R38 is expressed in human upper respiratory epithelium and is activated in response to acyl-homoserine lactone[ncbi.nlm.nih.gov] Blowing your nose forcefully transports air, mucus, and bacteria into the sinuses; this can worsen sinus pressure and potentially increase the risk of a secondary bacterial[studenthealth.ucsf.edu] Basic science research has indicated that the T2R38 receptor is activated by acyl-homoserine lactone (AHL) molecules secreted by gram-negative bacteria, including Pseudomonas[ncbi.nlm.nih.gov]

  • Psoralen

    Psoralen Catalogue number: P839800 Chemical name: Psoralen Synonyms: 7H-Furo[3,2-g][1]benzopyran-7-one; Furocoumarin; 3-(6-Hydroxy-5-benzofuranyl)-2-propenoic Acid δ-Lactone[trc-canada.com] The mechanism by which psoralen is transported across the placenta was investigated in the BeWo human placental cell line derived from choriocarcinoma in a transwell assay[ncbi.nlm.nih.gov] 2-Propenoicacid,3-(6-hydroxy-5-benzofuranyl)-,δ-lactone 3-(6-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone 5-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone 6,7-Furanocoumarin[chemicalbook.com]

  • Eucommia

    Computational modeling showed that catechin, α-d-glucopyranose and d-mannono-1,4-lactone docked tightly into the sucrase active site with low binding energies.[ncbi.nlm.nih.gov] , many people who react to the Asteraceae plants (the largest flowering plant family, known for high frequency of causing contact dermatitis, mainly due to sesquiterpene lactones[itmonline.org] Moreover, 1.0mg/mL EEUL decreased glucose transport in cells by 26.25 0.86%.[ncbi.nlm.nih.gov]

  • Gemfibrozil

    […] of G2 to yield atorvastatin lactone.[ncbi.nlm.nih.gov] On the other hand, hOAT1 and hOAT2 did not transport pravastatin.[ncbi.nlm.nih.gov] […] anion transporter 3.[ncbi.nlm.nih.gov]

  • Digitalis

    Digitalis compounds are characterized by a cis/trans/cis steroidal skeleton with an alpha,beta-unsaturated lactone (gamma-butyrolactone) in the 17beta-position, a 14beta-hydroxy[ncbi.nlm.nih.gov] No transport was observed for the other compounds in any of the studied transporters.[ncbi.nlm.nih.gov] Our results showed that a δ-lactone ring and a sugar moiety at 3β of the steroid body are favorable for DLC binding to P-gp.[ncbi.nlm.nih.gov]

  • Pravastatin

    These metabolites were present in roughly equal concentrations after dosing with the lactones LV and SV.[scipers.com] Based on these results, we suggest that CyA transport may be competitively inhibited by pravastatin via MRP2.[ncbi.nlm.nih.gov] […] the role of drug transport and drug metabolism in a given drug-drug interaction.[ncbi.nlm.nih.gov]

  • Atorvastatin

    The in vivo presence of atorvastatin lactone (ARVL) was explicitly taken into account by using pure ARVL in analogous experiments.[ncbi.nlm.nih.gov] We aimed to investigate the influence of two single nucleotide polymorphisms (SNP) (ABCB1 rs1128503 and ABCG2 rs2231142) in the ABC transporter genes on response to short-term[ncbi.nlm.nih.gov] […] and o‐OH‐lactone compounds.[academic.oup.com]

  • Cerivastatin

    Gemfibrozil increased the AUC(0-infinity) of cerivastatin lactone, on average, to 440% (94% to 594%; P .0024) and that of metabolite M-1 to 435% (216% to 802%; P .0002) of[ncbi.nlm.nih.gov] […] study, we examined the inhibitory effects of GEM and its metabolites, M3 and gemfibrozil 1-O-beta-glucuronide (GEM-1-O-glu), on the uptake of CER by human organic anion transporting[ncbi.nlm.nih.gov] First, cerivastatin is enantiomerically pure and is in an active β-hydroxy acid form, whereas lovastatin is administered as a lactone prodrug form and is dependent upon first-pass[clincancerres.aacrjournals.org]

  • Reserpine

    This facilitated the formation of a five-membered lactone ring (9.2C) . The alternate six-membered lactone ring was presumably more strained.[chemwiki.ucdavis.edu] Previous studies indicate that reserpine may disrupt dopamine transporter activity.[ncbi.nlm.nih.gov] Treatment of this tricyclic lactone with bromine in methanol then effected bromoetherification of the remaining alcohol.[brsmblog.com]

  • Junctional Epidermolysis Bullosa

    Exposure of the patient's keratinocytes to the proteasomal inhibitor clasto-lactacystin beta-lactone increased the expression of the mutated beta4 integrin chains indicating[ncbi.nlm.nih.gov] As a reason why the present case showed lethal phenotype despite the in-frame deletion mutation, rapid degradation of neo-synthesized α6 protein and/or impaired transport[ncbi.nlm.nih.gov]

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