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26 Possible Causes for Large Agranular Platelets

  • Gray Platelet Syndrome

    NBEAL2 expression is also required for the development of thrombocytes in zebrafish.GPS is characterized by "thrombocytopenia, and abnormally large agranular platelets in[en.wikipedia.org] Affected males had a mild bleeding disorder, thrombocytopenia, and large agranular platelets characteristic of GPS, while obligate carrier females were asymptomatic but had[ncbi.nlm.nih.gov] Grey Platelet Syndrome (GPS)- Patient Smear (Large agranular platelets) References: Tags: agranular platelet, alpha granules, bleeding, Desmopressin, Electron Microscopy,[medical-labs.net]

  • Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

    Large, pale and agranular platelets are seen in about a fourth of ARC syndrome patients, can be associated with absent or abnormal alpha granules on electron microscopy [[casereports.in]

  • Idiopathic Refractory Anemia

    , agranular platelets, and megakaryocytes (in MDS-F) Bone marrow biopsy : hypercellular, dysplastic bone marrow with numerous cells of all three cell lines with blasts, megakaryocytes[amboss.com] […] possible findings Leukocytopenia and/or thrombocytopenia Nucleated RBCs, ringed sideroblasts, Howell-Jolly bodies, basophilic stippling Neutrophils with hypolobulated nuclei Large[amboss.com]

  • Myelodysplasia

    Platelets may be large or agranular. Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis.[clinicaladvisor.com] A morphologic review of the peripheral blood smear often reveals dysplasia in the neutrophils, including hypogranularity or atypically large granules in the cytoplasm (pseudoChediak-Higashi[clinicaladvisor.com]

  • Alpha-Thalassemia-Myelodysplastic Syndrome

    - large and agranular MDS primarily in middle aged women macrocytic anemia and normal/inc platelets megakaryocytes have hypolobulated nuclei favorable clinical course EPO[brainscape.com] […] anisocytosis, normo-mildly macrocytic, low retics, Howell Jolly bodies, Cabot rings, basophilic stipling WBCs - small poorly granulated neutrophils w/ hyper or hypo lobed nuclei platelets[brainscape.com]

  • Myelofibrosis

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Secondary Myelofibrosis

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Acute Panmyelosis with Myelofibrosis

    Circulating micromegakaryocytes, megakaryoblastic fragments, dysplastic large platelets, and hypogranular neutrophils.[wiki.clinicalflow.com] Agranular, basophilic cytoplasm with pseudopod formation. Lymphoblast-like morphology (high nuclear-cytoplasmic ratio) in some cases.[wiki.clinicalflow.com]

  • Refractory Anemia with Excess Blasts

    Platelets may be large or agranular. Red cell morphology in the peripheral blood may be normal or macrocytic with anisopoikilocytosis.[clinicaladvisor.com] A morphologic review of the peripheral blood smear often reveals dysplasia in the neutrophils, including hypogranularity or atypically large granules in the cytoplasm (pseudoChediak-Higashi[clinicaladvisor.com]

  • Inherited Platelet Disorder

    […] syndrome § Large and agranular, thrombocytopenia § Contents of alpha granules are absent eg.[ihaematology.com] PF4, PDGF, VWF, fibrinogen § Platelet nucleotides ar e normal § EM demonstrates reduced or a bsent granules § Aggregation – reduced response to collagen and ADP § Associated[ihaematology.com] Reduced or irregular dense bodies § Idiopathic deficiency / δ–storage pool disease α -granule disorder s (CD62P P-selectin) § Alpha-granules contain PDGF and PF4 § Grey platelet[ihaematology.com]

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