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39 Possible Causes for Large Agranular Platelets

  • Gray Platelet Syndrome

    Affected males had a mild bleeding disorder, thrombocytopenia, and large agranular platelets characteristic of GPS, while obligate carrier females were asymptomatic but had[ncbi.nlm.nih.gov] Grey Platelet Syndrome (GPS)- Patient Smear (Large agranular platelets) References: Tags: agranular platelet , alpha granules , bleeding , Desmopressin , Electron Microscopy[medical-labs.net] […] of thrombocytes in zebrafish. [6] GPS is characterized by " thrombocytopenia , and abnormally large agranular platelets in peripheral blood smears." [7] The defect in GPS[en.wikipedia.org]

  • Primary Myelofibrosis

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Myelodysplastic Syndrome due to 5q Deletion

    , agranular platelets , and megakaryocytes (in MDS-F) Bone marrow biopsy : hypercellular, dysplastic bone marrow with numerous cells of all three cell lines with blasts, megakaryocytes[amboss.com] […] possible findings Leukocytopenia and/or thrombocytopenia Nucleated RBCs , ringed sideroblasts , Howell-Jolly bodies , basophilic stippling Neutrophils with hypolobulated nuclei Large[amboss.com]

  • Idiopathic Refractory Anemia

    , agranular platelets , and megakaryocytes (in MDS-F) Bone marrow biopsy : hypercellular, dysplastic bone marrow with numerous cells of all three cell lines with blasts, megakaryocytes[amboss.com] […] possible findings Leukocytopenia and/or thrombocytopenia Nucleated RBCs , ringed sideroblasts , Howell-Jolly bodies , basophilic stippling Neutrophils with hypolobulated nuclei Large[amboss.com]

  • Myelofibrosis

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Secondary Myelofibrosis

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Essential Thrombocythemia

    platelets and increased platelets; bizarre shapes, pseudopods and agranular forms Bone marrow : mildly hypercellular, increased number and large forms of megakaryocytes with[pathologyoutlines.com] Treatment High risk patients (for thrombosis) get cytoreductive therapy (hydroxyurea) and low dose aspirin Microscopic (histologic) description Peripheral blood : abnormally large[pathologyoutlines.com]

  • Thrombocythemia 2

    platelets and increased platelets; bizarre shapes, pseudopods and agranular forms Bone marrow : mildly hypercellular, increased number and large forms of megakaryocytes with[pathologyoutlines.com] Treatment High risk patients (for thrombosis) get cytoreductive therapy (hydroxyurea) and low dose aspirin Microscopic (histologic) description Peripheral blood : abnormally large[pathologyoutlines.com]

  • Myeloid Metaplasia

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

  • Leukoerythroblastic Anemia

    […] atypical, partially agranular platelets Cell intermediate between megakaryoblast and micromegakaryocyte Initial hypercellular phase: Granulocytes and clusters of megakaryocytes[pathologyoutlines.com] […] hosted on PathOut server: Peripheral blood: Moderate anisopoikilocytosis with dacrocytes and elliptocytes Postsplenectomy patient has marked increase in normoblasts and large[pathologyoutlines.com]

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