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31 Possible Causes for Large Breast, Thyroxin Binding Globulin Increased

  • Third Trimester Pregnancy

    The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…][ncbi.nlm.nih.gov]

  • Preeclampsia

    Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet. 2001;69(1):138–47. 7.[bmcpregnancychildbirth.biomedcentral.com] Exploring the performance of multifactor dimensionality reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models.[bmcpregnancychildbirth.biomedcentral.com]

  • Ectopic Pregnancy

    At first, you may have typical early signs of pregnancy, such as breast soreness or nausea.[avawomen.com] Later symptoms As the embryo grows too large for the confined space in the tube, the first sign that something is wrong may be a stabbing pain in the pelvis or abdomen.[medical-dictionary.thefreedictionary.com] Ectopic pregnancies may produce different symptoms in different women—especially early on, before the fertilized egg has grown large enough to cause any pain or other symptoms[avawomen.com]

  • Acute Fatty Liver of Pregnancy

    We report a case of fatty infiltration of the liver in a 27-year-old Hispanic woman. She went to an outside hospital in her third trimester of pregnancy with abdominal pain, jaundice, peripheral edema, and diffuse intravascular coagulation. An emergent cesarean section was performed, and she developed symptoms of[…][ncbi.nlm.nih.gov]

  • Oral Contraceptive

    Thyroxine-binding globulin capacity may increase in OC users; however, free thyroxine levels, thyroid-stimulating hormone levels, and thyroid function are not affected.[merckmanuals.com] Q-K: Can you comment on why a recent large study published by researchers at Harvard claimed to show no increased risk of developing breast cancer in women who had taken OCPs[polycarp.org] In conclusion, this study, one of the largest evaluating COX-2 expression in breast cancer, indicates that the prognostic impact of COX-2 expression depends on host factors[ncbi.nlm.nih.gov]

  • Inflammatory Bowel Disease Type 1

    Several reports suggest that people who were breast-fed may be protected from developing inflammatory bowel disease.[msdmanuals.com] The most common symptoms of Crohn disease are Crampy abdominal pain Chronic diarrhea (which sometimes is bloody when the large intestine is severely affected) Fever Loss of[msdmanuals.com]

  • De Quervain Thyroiditis

    This test should be performed in patients with symptomatic thyrotoxicosis when there are no clear signs of Graves' disease, such as large goiter or ophthalmopathy.[enotes.tripod.com] Because radioactive iodine is secreted in breast milk and 123 I has a half-life of 13 hours, nursing mothers need to pump and discard milk for at least two days after the[enotes.tripod.com]

  • Hypothyroidism

    Risk of postpartum hyperthyroidism may be increased Increased thyroxin-binding globulin in the first trimester can result in TSH elevation to stabilize free thyroxine levels[ncbi.nlm.nih.gov] breast cancer mortality ( 18 ).[doi.org] In pregnancy, free thyroxine levels may be lower than anticipated due to increased binding to thyroid binding globulin and decreased binding to albumin.[en.wikipedia.org]

  • Familial Papillary or Follicular Thyroid Carcinoma

    TBG (thyroxin binding globulin) increases due to stimulation from placental E2 and E3 (oestradiol and oestriol) and to reduced hepatic clearance.[ncbi.nlm.nih.gov] Factors affecting poor outcome  Large primary tumor  Age 45 years  Male sex  Lymph nodal metastases  Distant metastases  Multifocal disease  Extra-thyroidal extension[slideshare.net] Distant metastases often affect multiple organs, including the lungs, bones and liver and, more rarely, the brain, skin and breast.[patient.info]

  • Gonadotropic Pituitary Adenoma

    As hepatic corticosteroid-binding globulin and thyroxin (T4)-binding globulin production significantly increased under the effect of placental estrogen during normal pregnancy[journals.lww.com] In rare cases, men may secrete milk from their breasts or, when the prolactinoma is large, blindness or difficulty seeing can occur.[my.clevelandclinic.org] Normally, prolactin secretion by the pituitary gland stimulates a woman's breast to produce breast milk.[pituitary.ucla.edu]

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