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2 Possible Causes for Large Cafe Au Lait Spots with Irregular Margins

  • McCune-Albright Syndrome

    The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Albright. MAS is characterized by a triad of physical signs: café-au-lait spots, polyostotic fibrous dysplasia and autonomous endocrine hyperfunction. MAS is predominantly observed in girls and is rarely[…][]

  • Idiopathic Juvenile Osteoporosis

    Affected patients show a variable phenotype, including bone deformities and skin lesions (large cafe-au-lait spots with irregular margins) [ 65 ].[]

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