Large Feet: Causes & Reasons

Possible Causes for Large Feet

Congenital Generalized Lipodystrophy Type 1

[…] hands large hand 0001176 Lipodystrophy Inability to make and keep healthy fat tissue 0009125 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 [rarediseases.info.nih.gov]

Macrotia Large ears 0000400 Mandibular prognathia Big lower jaw Increased projection of lower jaw Increased size of lower jaw Large lower jaw Prominent chin Prominent lower [rarediseases.info.nih.gov]

[…] triglycerides [ more ] 0002155 Insulin-resistant diabetes mellitus at puberty 0000877 Labial hypertrophy Enlargement of the labia Enlargement of the vaginal lips [ more ] 0000065 Large [rarediseases.info.nih.gov]

Gigantism

The hands and feet are large, the head large and dolichocephalic, the eyes have an antimongoloid slant, with hypertelorism. [medical-dictionary.thefreedictionary.com]

• Headaches• Increased sweating• Irregular periods (females)• Large hands and feet with large fingers and toes 4. • Release of breast milk• Thickening of facial features [slideshare.net]

There is no uniform phenotype for patients with gigantism, but coarse facial features and large hands and feet have been described in several patients. [visualdx.com]

Sotos Syndrome

During follow up, the facies of Sotos syndrome was noted (fig 5 ) and the hands and feet were large with deep creases in the soles of the feet (fig 6 ). [jmg.bmj.com]

[…] hands and feet with advanced bone age, craniofacial dysmorphic features, learning disability, and possible susceptibility to tumors. [ncbi.nlm.nih.gov]

feet Hypertelorism Hypotonia Gum abscesses Unusually large body Delay in developmental milestones Epilepsy Advance teeth development Missing Teeth Weak Enamel Poor alignment [syndromespedia.com]

Patterson Pseudoleprechaunism Syndrome

body disproportion (comprising large hands, feet, nose and ears), hirsutism and severe intellectual disability. [malacards.org]

Symptoms - Patterson pseudoleprechaunism syndrome * Large hands * Large feet * Large nose * Large ears * Loose skin * Bronze skin pigmentation * Thick hair * Mental retardation [checkorphan.org]

[…] definition Pseudoleprechaunism syndrome, Patterson type is a rare, genetic, adrenal disorder characterized by congenital bronzed hyperpigmentation, cutis laxa of the hands and feet [orpha.net]

Acromegaly

They include: a large jaw and tongue gaps between the teeth a more prominent brow swollen hands large feet rough and oily skin skin tags Other changes include: tingling and [medicalnewstoday.com]

[…] bones of the face, large jaw and tongue, widely spaced teeth Large feet (change in shoe size), large hands (change in ring or glove size) Large glands in the skin (sebaceous [medlineplus.gov]

[…] childhood) Excessive sweating Headache Heart enlargement, which can cause fainting Hoarseness Joint pain, limited joint movement, swelling of the bony areas around a joint Large [nlm.nih.gov]

Cockayne Syndrome

The arms and legs are disproportionately long with large hands and feet and flexion contractures of joints. The children burn after even minimal sun exposure. [medicinenet.com]

CLOVES Syndrome

Overgrowth of extremities (usually arms or legs) is seen, with large wide hands or feet, large fingers or toes, wide space between fingers, and asymmetry of body parts. [en.wikipedia.org]

Large wide hands or feet, large fingers or toes, wide space between digits (sandal gap toe) and uneven size of extremities are common. 4. [rarediseases.org]

Donohue Syndrome

[…] hands large hand 0001176 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 Low-set ears Low set ears Lowset ears [ more ] 0000369 Nail dysplasia [rarediseases.info.nih.gov]

A, Abdominal distension, inguinal hernia, large hands and feet, clitoromegaly, and lipohypotrophy. [academic.oup.com]

Other abnormalities that have been observed in infants with leprechaunism include recurrent infections, abnormalities of the intellect and unusually large hands and feet. [symptoma.com]

Acromegaly - Cutis verticis gyrata - Corneal Leukoma Syndrome

[…] hands large hand 0001176 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 Mandibular prognathia Big lower jaw Increased projection of lower jaw [rarediseases.info.nih.gov]

Systemic Features: Affected individuals are unusually tall and have large hands, feet and chin. [disorders.eyes.arizona.edu]

Abnormal eye 0000478 Autosomal dominant inheritance 0000006 Cutis gyrata of scalp Furrows in thickened skin on top of scalp Thickened folds on top of scalp [ more ] 0010541 Large [rarediseases.info.nih.gov]

Mulibrey Nanism Syndrome

Symptoms - Mulibrey Nanism syndrome * Fetal growth retardation * Low birth weight * Short stature * Large hands * Large feet * Long head * J-shaped sella turcia * Triangular [checkorphan.org]

References Gastrointestinal Hepatomegaly Growth Adult height ranges from 136 to 161 cm for males and from 126 to 151 cm for females Delayed puberty Hands and feet appear relatively [datagenno.com]

Only at 3 years did the patient exhibit a large head circumference (the head was disproportionately large in comparison with the body), prominent forehead, anteverted nares [ijponline.biomedcentral.com]

McCune-Albright Syndrome

This results in a condition called acromegaly, characterized by large hands and feet, arthritis, and coarse facial features. [chop.edu]

Excess growth hormone can result in acromegaly, a condition characterized by large hands and feet, arthritis, and distinctive facial features that are often described as " [encyclopedia.pub]

Pituitary Carcinoma

[…] hands and feet ( acromegaly ) producing breast milk even if not pregnant lack of milk when breast-feeding menstrual cycle changes lowered sex drive impotence loss of body [healthline.com]

[…] head, coarse facial features, very large hands and feet, and sometimes, behavioral and visual problems. [drugs.com]

and facial features (acromegaly) in older patients Many patients are not diagnosed until the tumor is large enough to cause visual symptoms. [willseye.org]

Pituitary Neoplasm

[…] hands and feet ( acromegaly ) producing breast milk even if not pregnant lack of milk when breast-feeding menstrual cycle changes lowered sex drive impotence loss of body [healthline.com]

and facial features (acromegaly) in older patients Many patients are not diagnosed until the tumor is large enough to cause visual symptoms. [willseye.org]

If an adult makes too much growth hormone, the bones of the hands, feet, and face continue to grow and become quite large, causing their normal features to become distorted [cancer.org]

Congenital Generalized Lipodystrophy Type 2

Affected individuals tend to have prominent bones above the eyes (orbital ridges), large hands and feet, and a prominent belly button (umbilicus). [ghr.nlm.nih.gov]

Adults may have large hands and feet and a strong, square jawbone if their hormone balance is off and they've kept growing. [webmd.com]

Her hands and feet were large as observed in acromegaly. Her facial features were exaggerated due to prominence of the mandibular bone. [journals.sagepub.com]

Primary Hypertrophic Osteoarthropathy

[…] hands and feet; periosteal lesions, fatigability, blepharitis, arthralgia, periosteal overgrowth, and occasionally pulmonary osteoarthropathy. [whonamedit.com]

Patients also suffer large skin folds on the face and scalp, excessive perspiration, enlargement of the extremities, and nonspecific pain in the bones and joints. [gamma.wustl.edu]

Hyperhidrosis in association with keratoderma and strikingly large hands and feet: a rare case of pachydermoperiostosis. Clin Exp Dermatol. 2010;35(3): e16–e17. 41. [jcadonline.com]

Congenital Generalized Lipodystrophy

Affected individuals tend to have prominent bones above the eyes ( orbital ridges ), large hands and feet, and a prominent belly button (umbilicus). [ghr.nlm.nih.gov]

Continued Adults with CGL have large hands and feet and a strong, square jawbone because their hormone balance is off and they keep growing. [webmd.com]

Proteus Syndrome

Although she was born with abnormally large legs and feet - which continue to grow - her body is of average size. [news.bbc.co.uk]

Custom made shoes with a heel lift were provided to the patient to accommodate her very large and deformed feet and to compensate for the leg length problem. [imedpub.com]

[…] hands and/or feet. [proteus-uk.org]

Diencephalic Syndrome

Disproportionately large hands and feet have been described in rare cases. [pituitaryadenomas.com]

Lipodystrophy

Adults may have large hands and feet and a strong, square jawbone if their hormone balance is off and they've kept growing. [webmd.com]

Patients with the early-onset hyperinsulinemia in combination with congenital generalized lipoatrophy develop acromegaloid features (large hands, feet, and jaw) with soft [emedicine.com]

She could have a large liver or spleen. APL. This type affects just the upper body, on both sides. [webmd.com]

Profound Intellectual Disability

deformities of the hands or feet, and seizures. 121 Mental retardation is a permanent condition, however the majority of individuals with mental retardation can receive [www150.statcan.gc.ca]

[…] individuals may have noticeable physical or neurological abnormalities that may be suggestive of mental retardation, such as unusual facial features, a head that is too small or large [www150.statcan.gc.ca]

Spondyloepimetaphyseal Dysplasia Type Bieganski

brachydactyly large, broad feet Skeletal: spondyloepimetaphyseal dysplasia delayed bone age joint contractures Skin Nails Hair Hair: low frontal hairline prominent eyebrows [malacards.org]

There was exaggerated thoracic kyphosis.The hands and feet were large and broad (Fig. 1A) Physical ex-amination of the chest and abdomen were normal. [docslide.net]

[…] odontoid hypoplasia exaggerated thoracic kyphosis Chest Ribs Sternum Clavicles And Scapulae: thin ribs anterior rib cupping prominent sternum inferior rib flaring Skeletal Feet [malacards.org]

Cerebro-Oculo-Facio-Skeletal Syndrome

Ozdirim et al13 described large feet and hands in 14 of 25 patients (56%) but did not mention edema. [jamanetwork.com]

Affected individuals typically have large hands and feet and unusually long arms and legs in proportion to the size of their body. [rarediseases.org]

[…] psychomotor skills lack of language development Microphthalmia, anophthalmia, cataract, blepharophimosis Facial dysmorphism with a prominent root of the nose, microgenius, large [de.zxc.wiki]

Alpha-Mannosidosis

National Organization for Rare Disorders, Inc. Skip to the navigation Synonyms alpha-mannosidase B deficiency lysosomal alpha-D-mannosidase deficiency mannosidase, alpha B, lysosomal mannosidosis mannosidosis, alpha B, lysosomal Disorder Subdivisions None General Discussion Summary Alpha-mannosidosis is a rare genetic[…] [metrohealth.net]

17q11 Microdeletion Syndrome

(D) webbed neck, large feet, and hands (E) Juvenile xanthogranuloma NFNS is typically described as a rare autosomal dominant disorder with combined clinical features of NF1 [onlinelibrary.wiley.com]

[…] milder manifestations of NF1; Type-1 NF1 deletions were found to be disproportionately associated with facial dysmorphic features (90% of patients), tall stature (46%), large [genatlas.medecine.univ-paris5.fr]

[…] hands and feet, connective tissue dysplasia (joint hyperflexibility, soft palm skin), muscular hypotonia, scoliosis, pectus excavatum, and bone cysts. [malacards.org]

Gastro-Entero-Pancreatic Neuroendocrine Tumor

Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are rare and complex neoplasms. The term comprises pre-neoplastic lesions, well-differentiated tumors, and poorly differentiated carcinomas - all of them originating from neuroendocrine cells -, as well as mixed neoplasms of variable malignancy. They may develop[…] [symptoma.com]

Macrodactyly of the Foot

PROCEDIMIENTOS E INTERVENCIONES, NO CLASIFICADOS BAJO OTROS CONCEPTOS CIRUGIA ASISTIDA POR ORDENADOR OPERACIÓNES SOBRE NERVIOS PERIFÉRICOS DESTRUCCIÓN NERVIO PERIFÉRICO SUTURA NERVIO PERIFÉRICO LIBERACIÓN TÚNEL CARPIANO LIBERACIÓN TÚNEL TARSAL.ABIERTA. TIBIAL POSTERIOR INJERTO NERVIO PERIFÉRICO TRANSPOSICIÓN NERVIO[…] [sspa.juntadeandalucia.es]

Renon-Delille Syndrome

Online Dictionary renon-delille(syndrome) 解释 search Renon-Delille(syndrome) 在医学专业词典中的解释: 雷-德二氏综合征:肢端肥大伴甲状腺-卵巢缺陷症候群相关词: Reno Reno- reno-interstinal reno-intestinal Reno-M reno-renal reflex reno-sialidosis reno-vascular hyperte-tion reno-vascular hypertension reno-vascular reconstruction renoarteriography[…] [zh-cn.oldict.com]

CHIME Syndrome

Abstract CHIME syndrome is the acronym for a multisystem disorder consisting of Coloboma, Heart defects, Ichthyosiform dermatosis, Mental retardation, and Ear anomalies with hearing loss. Characteristic features of CHIME syndrome include: (1) retinal coloboma; (2) congenital heart defects; (3) migratory[…] [link.springer.com]

Acromesomelic Dysplasia Type Hunter-Thomson

[…] and large joint dislocations. [rareguru.com]

[…] affecting the lower limbs more than upper limbs, with middle and distal segments being the most affected), severe shortening, absence or fusion of tubular bones of hands and feet [rareguru.com]

Gigantism - Acromegaly

[…] facial features Large hands and feet Large tongue with deep furrows Large tongue observed in a patient with acromegaly ( source ) HOW DO WE CONFIRM A DIAGNOSIS? [stepwards.com]

A person with the condition will take on a certain appearance, with large hands and feet, larger facial features, jaw, and cheekbones, and of course excessive height, if affected [tallclub.co.uk]

The extremities also grow more than the rest of the body, leading to disproportionately large hands and feet, and a characteristic large-boned face. [damninteresting.com]