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103 Possible Causes for Large Feet, Thick Facial Skin, Weight Gain

  • Acromegaly

    […] bones of the face, large jaw and tongue, widely spaced teeth Large feet (change in shoe size), large hands (change in ring or glove size) Large glands in the skin (sebaceous[nlm.nih.gov] The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, thick lips and marked facial lines.[orpha.net] We report the case of a 43 years old patient initially diagnosed with acromegaly accompanied by weight gain and acral enlargement.[ncbi.nlm.nih.gov]

  • Pituitary Gland Carcinoma

    Too much of this hormone causes weight gain, particularly in the body’s trunk.[cancer.net] […] hands and feet ( acromegaly ) producing breast milk even if not pregnant lack of milk when breast-feeding menstrual cycle changes lowered sex drive impotence loss of body[healthline.com] If the tumor develops after puberty, then the person has the following symptoms of acromegaly: thick, oily skin; coarse features with thick lips and a broad nose; prominent[drugs.com]

  • Donohue Syndrome

    Our finding that replacement treatment with pancreatic enzymes improved weight gain (case 2) implies that all patients with Donohue syndrome should be investigated for exocrine[ncbi.nlm.nih.gov] […] hands large hand 0001176 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 Low-set ears Low set ears Lowset ears [ more ] 0000369 Nail dysplasia[rarediseases.info.nih.gov] She appeared markedly emaciated, and had hirsuitism, thickened skin with patchy hyperpigmentation, coarse facial features, sunken cheeks, pointed chin, flared nostrils, broad[indianpediatrics.net]

  • Lipodystrophy

    Three patients with obesity developed in vitro neutralizing activity coincident with weight gain.[ncbi.nlm.nih.gov] Adults may have large hands and feet and a strong, square jawbone if their hormone balance is off and they've kept growing.[webmd.com] Sculptra doesn't correct the underlying cause of the facial fat loss, but does help improve the appearance by increasing skin thickness in the treated area.[thebody.com]

  • Acromegaly - Cutis verticis gyrata - Corneal Leukoma Syndrome

    Two patients died in the immediate postoperative period, and 10 patients received radiotherapy with “reversal of their diencephalic syndrome” (weight gain, deposition of subcutaneous[medtextfree.wordpress.com] […] hands large hand 0001176 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 Mandibular prognathia Big lower jaw Increased projection of lower jaw[rarediseases.info.nih.gov] Upon examination, he was a well-built muscular male with coarse facial features with broadening of the nasal bridge and thick lips.[ncbi.nlm.nih.gov]

  • Growth Hormone Deficiency

    The symptoms might include swelling in the hands and feet, pain in the large joints, and carpal tunnel syndrome.[ccpd.ucsf.edu] However, a nice side benefit is that growth hormone also increases the thickness of the skin.[drmarinajohnson.com] gain.[ncbi.nlm.nih.gov]

  • Gigantism

    Symptoms of severe hypopituitarism include: Loss of appetite Weight loss or weight gain Fatigue Decreased energy Decreased mental function Dizziness Changes in hormonal function[pituitary.ucla.edu] . • Headaches• Increased sweating• Irregular periods (females)• Large hands and feet with large fingers and toes 4. • Release of breast milk• Thickening of facial features[slideshare.net] The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, thick lips and marked facial lines.[doi.org]

  • Corticotroph Pituitary Adenoma

    It is part of a group of diseases that cause Cushing’s syndrome, characterized by signs and symptoms that may include weight gain around the trunk and in the face, stretch[rarediseases.info.nih.gov] […] head, coarse facial features, very large hands and feet, and sometimes, behavioral and visual problems.[drugs.com] Cushing’s Disease Symptoms The most common symptoms of Cushing’s disease are: unexplained weight gain, particularly around the neck and midsection, thinning of the arms and[mskcc.org]

  • Achard Thiers Syndrome

    Pregnancy causes weight gain and increases levels of estogen and placental hormones, which antagonize insulin. some medications such as thiazide diuretics, adrenal corticosteroids[checkorphan.org] Growth Mental Deficiency Syndrome of Myhre GROWTH RETARDATION, INTELLECTUAL DEVELOPMENTAL DISORDER, HYPOTONIA, AND HEPATOPATHY Growth Retardation, Small and Puffy Hands and Feet[rgd.mcw.edu] The hair itself is sometimes not particularly thick, but the roots are very large which cause a noticeable shadow under the skin.[anagentherapies.co.uk]

  • Hyperpituitarism

    If the adrenocorticotropic hormone (ACTH) is involved, patient present with symptoms of excessive glucocorticoid secretion: hypertension, hirsutism, weight gain, acne, fatigability[symptoma.com] , "doughy" hands; large feet; large face; enlarged jaw; tongue problems; big forehead; darkened skin in armpits; widely spaced teeth; oily, tough skin; skin pigmentation changes[diagnose-me.com] Serious physiological symptoms also may appear, such as increased sweating, thick and coarse oily skin, and chronic sinus congestion.[m.body-disease.com]

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