Large Joint Involvement: Causes & Reasons

Possible Causes for Large Joint Involvement

PVNS generally affects large joints but occasionally involves the temporomandibular joint (TMJ), with occasional extension into the middle cranial fossa. [ncbi.nlm.nih.gov]

This case described here is the first case of PVNS involving such a large numbers of joints that has been reported in the literature. [ncbi.nlm.nih.gov]

The diffuse form typically involves the large joints (see the first 2 images below), while the localized form typically occurs around the small joints of the hands and feet [emedicine.com]

Pseudogout

Chronic CPP crystal arthritis is much more difficult to manage than acute CPP crystal arthritis[1]: For patients with monoarticular or oligoarticular large-joint involvement [patient.info]

Patients with progressive large joint involvement such as the knee may benefit from joint replacement. [health24.com]

Primarily affects the elderly Usually involves large joints Symptom onset is usually insidious. [unboundmedicine.com]

Hemophilic Arthropathy

joint involvement, total joint replacement remains the only effective treatment for end-stage disease. [appliedradiology.com]

Large joints are most commonly involved in the following order of frequency 2 : knee elbow ankle hip shoulder Plain radiograph joint effusion is seen in the setting of hemarthrosis [radiopaedia.org]

The joint involvement was established on a scale of 0 (no abnormalities), I (minimal amount of hemosiderin), II (large amount of hemosiderin and isolated cartilaginous erosion [ncbi.nlm.nih.gov]

Rheumatic Fever

In ARF the large joints are involved while small joints are not. JIA can affect both large and small joints. [pmmonline.org]

This is the most common manifestation of ARF, usually involves large joints, and is migratory in nature. It responds dramatically to high-dose salicylates. Carditis. [web.archive.org]

- arthritis: the arthritis is typically symmetrical and involves large joints such as the knees, ankles, elbows, and wrists. [childrensheartinstitute.org]

Bacterial Arthritis

These levels were lower in patients with small joint involvement than in those with large joint involvement. [medpagetoday.com]

The proportion of patients with large joint involvement (hip and particularly knee) was significantly higher in the antibiotics+dexamethasone group (92.3%) than in the antibiotics-only [pediatrics.aappublications.org]

Late disease - is mainly involving joints, most commonly a single knee with intermittent, relatively painless large effusions lasting days or even weeks. [pmmonline.org]

Osteoarthritis

RESULTS: A 43-year-old Caucasian woman of normal stature presented with a 24-year history of symmetrical polyarticular OA involving both large and small joints. [ncbi.nlm.nih.gov]

These measures are particularly important when large, weight-bearing joints are involved, such as the hips or knees. [medicinenet.com]

In fact, even modest weight reduction can help to decrease symptoms of osteoarthritis of the large joints, such as the knees and hips. [medicinenet.com]

Ochronosis with Alkaptonuria

Musculoskeletal symptoms began in most of our patients around the age of 30 years with back pain and stiffness: involvement of the large peripheral joints usually occurred [ncbi.nlm.nih.gov]

[…] peripheral joint involvement usually takes place years after ochronotic spinal involvement, and the small joints of the hands and feet, wrists, elbows and ankles are rarely [archivesofrheumatology.org]

For large joints, involvement of the joint spaces was scored as absent (0); minimal, with osteophytes, subchondral cysts, or both, but no narrowing of joint spaces (1); mild [nejm.org]

Traumatic Arthropathy

The arthropathy principally involves large joints such as elbows, hips, knees, and ankles. [diki.pl]

Primary synovial (osteo)chondromatosis typically involves large joints. [jaocr.org]

Arthropathy with stiff joints, diabetes, or fatigue, may be the presenting complaint. Spondylarthropathy is any form of arthropathy of the vertebral column. [diki.pl]

Hemochromatosis

[…] arthroplasty indications large joint involvement Orthopaedic Manifestations Bilateral ankle arthritis hemochromatosis should be suspected when symmetrical ankle arthropathy [orthobullets.com]

large subchondral cysts, uniform loss of joint space and chondrocalcinosis. [rheumatologyadvisor.com]

[…] damage) phlebotomy regime indications weekly blood letting sessions to reduce serum ferritin levels contraindications severe anemia congestive heart failure Operative total joint [orthobullets.com]

Relapsing Polychondritis

large and small joints, with a predilection for the costochondral joints and knees. [msdmanuals.com]

The arthritis is usually asymmetric and oligo- or polyarticular, and it involves both large and small peripheral joints. [what-when-how.com]

Nasal cartilage inflammation is the next most common manifestation, followed by arthritis that varies from arthralgias to symmetric or asymmetric nondeforming arthritis involving [msdmanuals.com]

Behçet Disease

Joints[edit] Arthritis is seen in up to half of people, and is usually a non-erosive poly or oligoarthritis primarily of the large joints of the lower extremities.[4] Brain [en.wikipedia.org]

[edit] CNS involvement most often occurs as a chronic meningoencephalitis. [en.wikipedia.org]

[…] causing severe vascular collapse and death from bleeding in the lungs.[4] Nodules, consolidations, cavities and ground glass lesions are common in patients with pulmonary involvement [en.wikipedia.org]

Serum Sickness

Arthritis or arthralgias (10-50%) usually affect multiple large joints, but occasionally, small joints and joints of spine and temporomandibular joint may be inflamed. [whale.to]

Lymphadenopathy (10-20%) may be generalized or may involve tenderness in the nodes that drain the injection site; splenomegaly may occur. [whale.to]

Intermittent Hydrarthrosis

Other joints may also be involved along with the knee. Effusions are large, restricting range of motion but significant pain is not a feature. [en.wikipedia.org]

Signs and symptoms [ edit ] Repeated, periodic joint effusions of the knee. Usually one knee is affected but sometimes both knees. [en.wikipedia.org]

Tenderness of the joint may or may not be present. [1] Aspirated synovial fluid is usually sterile [2] but will sometimes show elevated cell count (>100 cells/mL) with 50% [en.wikipedia.org]

Shoulder Osteoarthritis

PURPOSE: The purpose of this study was to evaluate patients who underwent isolated arthroscopic debridement and capsular release without any other procedures for primary glenohumeral osteoarthritis to determine clinical and functional outcomes and time until conversion to shoulder arthroplasty. METHODS: We[…] [ncbi.nlm.nih.gov]

Hemophilia

Hemophilia is a heritable disease of abnormal or incomplete clotting. Hemophilia A is the most common hereditary disease associated with life-threatening bleeding. Hemophilia B is a less common variant of this disease which occurs due to a deficiency of Christmas factor (FIX). Hemophilia presents at birth or during[…] [symptoma.com]

Calcific Tendinitis of the Shoulder

OBJECTIVE: To define prognostic factors in chronically symptomatic patients with calcific tendinitis of the shoulder. METHODS: We evaluated 420 patients (488 shoulders) in the context of a prospective cohort study. Epidemiologic data were assessed. The radiographic and sonographic appearance of the calcific[…] [ncbi.nlm.nih.gov]

Eosinophilic Fasciitis

Eosinophilic fasciitis (), also known as "Shulman's syndrome", is a form of fasciitis, the inflammatory diseases that affect the fascia, the connective tissues surrounding muscles, blood vessels and nerves. Unlike other diseases in that category, it is limited to the arms and legs, and usually resolves itself, although[…] [en.wikipedia.org]

Ross River Fever

Ross River fever, which is also known as Ross River virus disease, is an infectious disease caused by the Ross River virus that is spread by mosquitoes. Affected patients typically experience symptoms similar to that of influenza, with fatigue and muscle aches. Ross River fever is endemic in Australia, Papua New[…] [news-medical.net]

Juvenile Seronegative Polyarthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

Types Pauciarticular (4 or fewer joints involved) Age at presentation Involves large joints and is typically asymmetric Boys may develop Sacroiliitis Iridocyclitis may be [fpnotebook.com]

It can be symmetrical with large and small joints involved with swelling. It can present with stiffness but minimal swelling. This is often a destructive arthritis. [patient.info]

Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations

[…] motion that can involve all large joints. [ncbi.nlm.nih.gov]

and limitation of range of motion that can involve all large joints. [ncbi.nlm.nih.gov]

Clinical features Joint dislocations at birth (knees, hips, radial heads) with short stature (Figure 1) Clubfeet Limitation of range of motion that can involve all large joints [ncbi.nlm.nih.gov]

Autosomal Recessive Spondyloepiphyseal Dysplasia Tarda

Onset (age ~3-6 yrs) begins w/involvement of interphalangeal joints; later involvement of large joints & spine causes significant joint contractures, gait disturbance, & scoliosis [ncbi.nlm.nih.gov]

[…] of articular cartilage w/progressive joint stiffness & enlargement & w/o inflammation. [ncbi.nlm.nih.gov]

Unlike X-linked SEDT, joint swelling & hand involvement are common features of PED. COL2A1 SED congenita (SEDC) (See Type II Collagen Disorders Overview.) [ncbi.nlm.nih.gov]

Spondyloepiphyseal Dysplasia Tarda

[…] of articular cartilage w/progressive joint stiffness & enlargement & w/o inflammation. [ncbi.nlm.nih.gov]

Unlike X-linked SEDT, joint swelling & hand involvement are common features of PED. COL2A1 SED congenita (SEDC) (See Type II Collagen Disorders Overview.) [ncbi.nlm.nih.gov]

Familial Broad Terminal Phalanges

Other than the hands and feet, no individuals reported any other large joint involvement or features of a systemic illness. [ojrd.biomedcentral.com]

Soft tissue swelling around the PIP joints, and less commonly the DIP joint, was described in all cases. [ojrd.biomedcentral.com]

Synovial Chondromatosis

joints. [thejns.org]

It most commonly involves large joints such as the knee, hip, and elbow, but its presence in smaller joints has also been reported. [mendeley.com]

Its involvement with the spine is rare; only six cases have been reported. The authors describe two patients with synovial chondromatosis involving the cervical spine. [thejns.org]

Juvenile Seropositive Polyarthritis

Although large-joint involvement could be seen, symmetrical small-joint arthritis is more typical. [ncbi.nlm.nih.gov]

Patients with polyarticular JIA usually have involvement of both large and small joints. [cincinnatichildrens.org]

There is usually a predilection for large joints rather than small joints. [radiopaedia.org]

Arthritis due to Ulcerative Colitis

It usually involves a few large joints at a time, most frequently a knee or ankle but sometimes a wrist. The joints are active when the colon is active. [hopkinsarthritis.org]

The common pattern of joint involvement was asymmetric arthritis in the lower extremities large joints. The most common type of arthritis was inflammatory. [cjhr.org]

The common pattern of joint involvement was asymmetric arthritis in in the lower extrimities large joints. The most common type of arthritis was inflammatory. [jmedsoc.org]

Juvenile Idiopathic Arthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

Most young children do not complain of stiffness or pain, but there may be changes in gait or function. 2 Any joint may be affected, but large joints are involved more frequently [web.archive.org]

Large as well as small joints are symmetrically involved and there is even involvement of the jaw and neck. [symptoma.com]

Polyarticular Juvenile Idiopathic Arthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

It is well known that JIA involves large joints—except hip—more often than small joints; our data showed that 92.68% (76/82) had large joint involvement either alone or associated [hindawi.com]

Types Pauciarticular (4 or fewer joints involved) Age at presentation Involves large joints and is typically asymmetric Boys may develop Sacroiliitis Iridocyclitis may be [fpnotebook.com]

Psoriatic Juvenile Idiopathic Arthritis

involvement: asymmetric oligoarthritis affecting large and small joints, with or without dactylitis, chronic uveitis, and antinuclear antibodies. [ncbi.nlm.nih.gov]

Clinical findings Joint involvement a) Large joints The most commonly involved large joints at both presentation and during the course of the disease were the knee (67%) and [ped-rheum.biomedcentral.com]

JPsA there are two or more conditions: one in which arthritis and psoriasis occur coincidentally, and a second in which psoriasis occurs with a characteristic pattern of joint [ncbi.nlm.nih.gov]

Enteropathic Arthritis

The joint problems involve large joints, such as the hips and sacroiliac joints. Swelling of entire toes or fingers, resulting in sausage digits, also occurs. [healthy.kaiserpermanente.org]

The arthritis typically affects large joints, such as the knees, hips, ankles, and elbows. In children, the arthritis may begin before the intestinal inflammation. [healthy.kaiserpermanente.org]

Enteropathic arthritis is spinal arthritis that also involves inflammation of the intestinal wall. Symptoms can come and go. [healthy.kaiserpermanente.org]