Large Joint Involvement: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Large Joint Involvement

Pigmented Villonodular Synovitis

PVNS generally affects large joints but occasionally involves the temporomandibular joint (TMJ), with occasional extension into the middle cranial fossa. [ncbi.nlm.nih.gov]

This case described here is the first case of PVNS involving such a large numbers of joints that has been reported in the literature. [ncbi.nlm.nih.gov]

[…] form. 5. • The diffuse form typically involves the large joints, while the localized form typically occurs around the small joints of the hands and fee 6. [slideshare.net]

Hemophilic Arthropathy

joint involvement, total joint replacement remains the only effective treatment for end-stage disease. [appliedradiology.com]

Large joints are most commonly involved in the following order of frequency 2 : knee elbow ankle hip shoulder Plain radiograph joint effusion is seen in the setting of hemarthrosis [radiopaedia.org]

The joint involvement was established on a scale of 0 (no abnormalities), I (minimal amount of hemosiderin), II (large amount of hemosiderin and isolated cartilaginous erosion [ncbi.nlm.nih.gov]

Pseudogout

Patients with progressive large joint involvement such as the knee may benefit from joint replacement. [health24.com]

Primarily affects the elderly Usually involves large joints Symptom onset is usually insidious. [unboundmedicine.com]

self-limiting, synovitis) Chronic CPPD crystal inflammatory arthritis (1)[C] Chronic CPPD crystal deposition may cause a progressive degenerative arthritis in numerous joints [unboundmedicine.com]

Rheumatic Fever

In ARF the large joints are involved while small joints are not. JIA can affect both large and small joints. [pmmonline.org]

This is the most common manifestation of ARF, usually involves large joints, and is migratory in nature. It responds dramatically to high-dose salicylates. Carditis. [web.archive.org]

- arthritis: the arthritis is typically symmetrical and involves large joints such as the knees, ankles, elbows, and wrists. [childrensheartinstitute.org]

Ochronosis with Alkaptonuria

Musculoskeletal symptoms began in most of our patients around the age of 30 years with back pain and stiffness: involvement of the large peripheral joints usually occurred [ncbi.nlm.nih.gov]

[…] peripheral joint involvement usually takes place years after ochronotic spinal involvement, and the small joints of the hands and feet, wrists, elbows and ankles are rarely [archivesofrheumatology.org]

For large joints, involvement of the joint spaces was scored as absent (0); minimal, with osteophytes, subchondral cysts, or both, but no narrowing of joint spaces (1); mild [nejm.org]

Bacterial Arthritis

These levels were lower in patients with small joint involvement than in those with large joint involvement. [medpagetoday.com]

The proportion of patients with large joint involvement (hip and particularly knee) was significantly higher in the antibiotics+dexamethasone group (92.3%) than in the antibiotics-only [pediatrics.aappublications.org]

Late disease - is mainly involving joints, most commonly a single knee with intermittent, relatively painless large effusions lasting days or even weeks. [pmmonline.org]

Traumatic Arthropathy

The arthropathy principally involves large joints such as elbows, hips, knees, and ankles. [diki.pl]

Primary synovial (osteo)chondromatosis typically involves large joints. [jaocr.org]

Arthropathy with stiff joints, diabetes, or fatigue, may be the presenting complaint. Spondylarthropathy is any form of arthropathy of the vertebral column. [diki.pl]

Osteoarthritis

RESULTS: A 43-year-old Caucasian woman of normal stature presented with a 24-year history of symmetrical polyarticular OA involving both large and small joints. [ncbi.nlm.nih.gov]

These measures are particularly important when large, weight-bearing joints are involved, such as the hips or knees. [medicinenet.com]

In fact, even modest weight reduction can help to decrease symptoms of osteoarthritis of the large joints, such as the knees and hips. [medicinenet.com]

Hemochromatosis

[…] arthroplasty indications large joint involvement Orthopaedic Manifestations Bilateral ankle arthritis hemochromatosis should be suspected when symmetrical ankle arthropathy [orthobullets.com]

large subchondral cysts, uniform loss of joint space and chondrocalcinosis. [rheumatologyadvisor.com]

[…] damage) phlebotomy regime indications weekly blood letting sessions to reduce serum ferritin levels contraindications severe anemia congestive heart failure Operative total joint [orthobullets.com]

Relapsing Polychondritis

large and small joints, with a predilection for the costochondral joints and knees. [msdmanuals.com]

The arthritis is usually asymmetric and oligo- or polyarticular, and it involves both large and small peripheral joints. [what-when-how.com]

Nasal cartilage inflammation is the next most common manifestation, followed by arthritis that varies from arthralgias to symmetric or asymmetric nondeforming arthritis involving [msdmanuals.com]

Behçet Disease

Joints[edit] Arthritis is seen in up to half of people, and is usually a non-erosive poly or oligoarthritis primarily of the large joints of the lower extremities.[4] Brain [en.wikipedia.org]

[edit] CNS involvement most often occurs as a chronic meningoencephalitis. [en.wikipedia.org]

[…] causing severe vascular collapse and death from bleeding in the lungs.[4] Nodules, consolidations, cavities and ground glass lesions are common in patients with pulmonary involvement [en.wikipedia.org]

Intermittent Hydrarthrosis

Other joints may also be involved along with the knee. Effusions are large, restricting range of motion but significant pain is not a feature. [en.wikipedia.org]

Signs and symptoms [ edit ] Repeated, periodic joint effusions of the knee. Usually one knee is affected but sometimes both knees. [en.wikipedia.org]

Tenderness of the joint may or may not be present. [1] Aspirated synovial fluid is usually sterile [2] but will sometimes show elevated cell count (>100 cells/mL) with 50% [en.wikipedia.org]

Serum Sickness

Arthritis or arthralgias (10-50%) usually affect multiple large joints, but occasionally, small joints and joints of spine and temporomandibular joint may be inflamed. [whale.to]

Lymphadenopathy (10-20%) may be generalized or may involve tenderness in the nodes that drain the injection site; splenomegaly may occur. [whale.to]

Shoulder Osteoarthritis

PURPOSE: The purpose of this study was to evaluate patients who underwent isolated arthroscopic debridement and capsular release without any other procedures for primary glenohumeral osteoarthritis to determine clinical and functional outcomes and time until conversion to shoulder arthroplasty. METHODS: We[…] [ncbi.nlm.nih.gov]

Hemophilia

Hemophilia is a heritable disease of abnormal or incomplete clotting. Hemophilia A is the most common hereditary disease associated with life-threatening bleeding. Hemophilia B is a less common variant of this disease which occurs due to a deficiency of Christmas factor (FIX). Hemophilia presents at birth or during[…] [symptoma.com]

Calcific Tendinitis of the Shoulder

OBJECTIVE: To define prognostic factors in chronically symptomatic patients with calcific tendinitis of the shoulder. METHODS: We evaluated 420 patients (488 shoulders) in the context of a prospective cohort study. Epidemiologic data were assessed. The radiographic and sonographic appearance of the calcific[…] [ncbi.nlm.nih.gov]

Eosinophilic Fasciitis

Eosinophilic fasciitis (), also known as "Shulman's syndrome", is a form of fasciitis, the inflammatory diseases that affect the fascia, the connective tissues surrounding muscles, blood vessels and nerves. Unlike other diseases in that category, it is limited to the arms and legs, and usually resolves itself, although[…] [en.wikipedia.org]

Ross River Fever

Abstract Ross River fever, or epidemic arthritis, is caused by the Ross River virus and usually mild and short-lived although persisting joint symptoms can develop. This article reviews the cause, diagnosis and treatment of this sometimes debilitating disease. [ncbi.nlm.nih.gov]

Juvenile Seronegative Polyarthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

Types Pauciarticular (4 or fewer joints involved) Age at presentation Involves large joints and is typically asymmetric Boys may develop Sacroiliitis Iridocyclitis may be [fpnotebook.com]

It can be symmetrical with large and small joints involved with swelling. It can present with stiffness but minimal swelling. This is often a destructive arthritis. [patient.info]

Gollop Coates Syndrome

[…] motion that can involve all large joints. [ncbi.nlm.nih.gov]

Clinical features Joint dislocations at birth (knees, hips, radial heads) with short stature (Figure 1) Clubfeet Limitation of range of motion that can involve all large joints [ncbi.nlm.nih.gov]

CHST3-related skeletal dysplasia is characterized by short stature of prenatal onset, joint dislocations (knees, hips, radial heads), clubfeet, and limitation of range of [ncbi.nlm.nih.gov]

Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations

and limitation of range of motion that can involve all large joints. [ncbi.nlm.nih.gov]

[from SNOMEDCT_US] From GeneReviews CHST3-related skeletal dysplasia is characterized by short stature of prenatal onset, joint dislocations (knees, hips, radial heads), clubfeet [ncbi.nlm.nih.gov]

Familial Broad Terminal Phalanges

Other than the hands and feet, no individuals reported any other large joint involvement or features of a systemic illness. [ojrd.biomedcentral.com]

Soft tissue swelling around the PIP joints, and less commonly the DIP joint, was described in all cases. [ojrd.biomedcentral.com]

Synovial Chondromatosis

joints. [thejns.org]

It most commonly involves large joints such as the knee, hip, and elbow, but its presence in smaller joints has also been reported. [mendeley.com]

Its involvement with the spine is rare; only six cases have been reported. The authors describe two patients with synovial chondromatosis involving the cervical spine. [thejns.org]

Arthritis due to Ulcerative Colitis

It usually involves a few large joints at a time, most frequently a knee or ankle but sometimes a wrist. The joints are active when the colon is active. [hopkinsarthritis.org]

The common pattern of joint involvement was asymmetric arthritis in the lower extremities large joints. The most common type of arthritis was inflammatory. [cjhr.org]

The common pattern of joint involvement was asymmetric arthritis in in the lower extrimities large joints. The most common type of arthritis was inflammatory. [jmedsoc.org]

Juvenile Idiopathic Arthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

Most young children do not complain of stiffness or pain, but there may be changes in gait or function. 2 Any joint may be affected, but large joints are involved more frequently [web.archive.org]

Large as well as small joints are symmetrically involved and there is even involvement of the jaw and neck. [symptoma.com]

Osteoarticular Tuberculosis

[ 5 ] Although Tbc can involve any area of the musculoskeletal system, the majority of the Tbc arthritis cases (~85%) present with chronic monoarthritis involving large and [archivesofrheumatology.org]

[…] medium weight-bearing joints with the hip and knee being the most common sites.[ 6 ] Acromioclavicular joint involvement is very rare in Tbc arthritis. [archivesofrheumatology.org]

[…] rekindled interest in Tbc encountered in rheumatology.[ 4 ] Skeletal Tbc occurs in 1%-3% of cases and represents a third form of extra pulmonary Tbc after ganglion and kidney involvement [archivesofrheumatology.org]

Polyarticular Juvenile Idiopathic Arthritis

involved large joint involvement (knees, ankles) asymmetric findings (leg length discrepancy, involved limb ends up LONGER) M:F =1:4, age 2-3y most common type early-onset [orthobullets.com]

It is well known that JIA involves large joints—except hip—more often than small joints; our data showed that 92.68% (76/82) had large joint involvement either alone or associated [hindawi.com]

Types Pauciarticular (4 or fewer joints involved) Age at presentation Involves large joints and is typically asymmetric Boys may develop Sacroiliitis Iridocyclitis may be [fpnotebook.com]

Psoriatic Juvenile Idiopathic Arthritis

involvement: asymmetric oligoarthritis affecting large and small joints, with or without dactylitis, chronic uveitis, and antinuclear antibodies. [ncbi.nlm.nih.gov]

Clinical findings Joint involvement a) Large joints The most commonly involved large joints at both presentation and during the course of the disease were the knee (67%) and [ped-rheum.biomedcentral.com]

JPsA there are two or more conditions: one in which arthritis and psoriasis occur coincidentally, and a second in which psoriasis occurs with a characteristic pattern of joint [ncbi.nlm.nih.gov]

Tumoral Calcinosis

Conclusion Tumour calcinosis generally occurs around large joints; involvement of small joints like hand and feet as in our case,is extremely rare. [jocr.co.in]

Involvement of large joints is typical, although the knee is rarely involved. The underlying bone is normal. [radiopaedia.org]

Tumoral calcinosis (TC) is a rare condition involving large joints and rarely the spine. It is characterized by calcification and swelling of periarticular tissues. [ncbi.nlm.nih.gov]

Synovial Osteochondromatosis

Synovial osteochondromatosis or synovial chondrometaplasia is an uncommon benign condition involving large joints such as the knee, hip, and elbow characterized by proliferation [scholars.opb.msu.edu]

This is classically seen in longstanding PSO after several local recurrences and involves the large joints. [em-consulte.com]

It most commonly involves large joints such as the knee, hip and elbow. [radiologyjournal.asia]