Possible Causes for Large Penis & Partly Unossified Atlas at Birth Wiedemann-Rautenstrauch Syndrome penis Growth Postnatal growth deficiency Hearing Sensorineural hearing loss Intrauterine development Intrauterine growth retardation Joints and Tendons Joint contractures [datagenno.com] […] hands large hand 0001176 Long foot Disproportionately large feet large feet long feet [ more ] 0001833 Long penis Enlarged penis 0000040 Macrocephaly Increased size of skull [rarediseases.info.nih.gov] Cardiovascular Cardiovascular abnormalities Ventricular dilatation with cortical atrophy Endocrine and/or Exocrine Hyperprolactinemia Hypothyroidism Genitourinary Hypoplastic prepuce Large [datagenno.com] Donohue Syndrome Affected females may have cystic ovaries and an abnormally enlarged clitoris/ breasts, while males may be afflicted with an abnormally large penis. [symptoma.com] Figure 4: Thin and emaciated extremity with protuberant abdomen and large penis Click here to view Leprechaunism was first described by Donohue (1948) [3] and since then it [e-ijd.org] Enlarged penis 0000040 Low-set, posteriorly rotated ears 0000368 Macrotia Large ears 0000400 Proptosis Bulging eye Eyeballs bulging out Prominent eyes Prominent globes Protruding [rarediseases.info.nih.gov] Bannayan-Riley-Ruvalcaba Syndrome […] bowel loops 4 pigmented macules on the glans of the penis (speckled penis) Musculoskeletal manifestations: hypotonia scoliosis pectus excavatum joint hyperextensibility Women [radiopaedia.org] The features of BRRS are large head size, benign polyps in the intestines, lipomas under the skin, and pigmented skin spots (macules) on the glans penis. [rareguru.com] pigmented spots (maculae) on the penis and benign tumors and tumor-like growths in the intestine called hamartomas. [rarediseases.org] Roberts Syndrome Enlarged penis (relatively large appearance in relation to the reduced limbs), hypospadias, cryptorchidism, hypogonadism [1, 3,14,17,23]. Female genitalia. [thefetus.net] Congenital Adrenal Hyperplasia due to 11-Beta-Hydroxylase Deficiency Fonti utilizzate nella revisione corrente Haldeman-Englert, C. (Reviewed 2015 October 27). Congenital adrenal hyperplasia. MedlinePlus Medical Encyclopedia. Available online at https://medlineplus.gov/ency/article/000411.htm. Accessed July 2017. Speiser, P. W. (2016 April). Congenital adrenal hyperplasia (CAH). National Adrenal[…] [labtestsonline.it] Zimmerman Laband Syndrome X-linked Mental Retardation Type Cabezas [ more ] 0000303 Micropenis Short penis Small penis [ more ] 0000054 Mood swings 0000720 Relative macrocephaly Relatively large head 0004482 Striae distensae Stretch marks [rarediseases.info.nih.gov] […] tongue [ more ] 0000158 Mandibular prognathia Big lower jaw Increased projection of lower jaw Increased size of lower jaw Large lower jaw Prominent chin Prominent lower jaw [rarediseases.info.nih.gov] […] more ] 0001249 Joint laxity Joint instability Lax joints Loose-jointedness Loosejointedness [ more ] 0001388 Macroglossia Abnormally large tongue Increased size of tongue Large [rarediseases.info.nih.gov] Penile Hematoma Hematoma of prepuce Hemorrhage of corpus cavernosum Hemorrhage of penis Hypertrophy of corpus cavernosum Hypertrophy of penis Irritation of penis Large penis Lichen planus [icdlist.com] This can cause the penis to have a large bump or irregularity on the shaft. There can also be a great deal of pain associated with the hematoma. [healthcentral.com] Large Penile Hematoma [gpvec.unl.edu] Fibular Dimelia-Diplopodia Syndrome […] anomalies Corpus cavernosum sclerosis Hypospadias/epispadias/bent penis Macropenis/megapenis/large penis Micropenis/small penis/agenesis Penis duplication/diphallia/penoscrotal [readbag.com] […] dysgenesis True hermaphrodism Clitoris/labia majora/labia minora/female external genitalia hypoplasia Male internal genitalia anomaly/deferent ducts agenesis/ectopy/duplication Penis [readbag.com] Alopecia - Hypogonadism - Extrapyramidal Syndrome unossified atlas at birth; Vertebral body hypoplasia; [Pelvis]; Hypoplastic ilia; Trident configuration of acetabula; [Limbs]; Thin diaphyses; Irregular metaphyseal endplates [findzebra.com] penis; Hypospadias (reported in 1 patient) SKELETAL: Joint contractures (less common); [Skull]; Pseudohydrocephalus; Persistent fontanelles; Widely open sutures; Hypoplasia [findzebra.com] Joint contractures (less common); [Skull]; Pseudohydrocephalus; Persistent fontanelles; Widely open sutures; Hypoplasia of the facial bones; Parietal bossing; [Spine]; Partly [findzebra.com] Congenital Absence of the Penis An abnormally large penis frequently is present in males with precocious puberty, dwarfism, an overactive pituitary, or adrenal tumours. [britannica.com] Examples Ambiguous genitalia - a large clitoris or small penis. Cryptorchidism - absence of one or both testes from the scrotum. This includes undescended testes. [ipfs.io] Secondary buried penis may be the result of an overzealous circumcision with subsequent cicatricial scar (trapped penis), a large hernia, or a hydrocele. [omicsonline.org] X-Linked Hypogonadotropic Hypogonadism without Anosmia […] and testes, as well as secondary sex characteristics, is largely normal. [symptoma.com] […] nXHH is associated with loss of libido, erectile dysfunctions, infertility, low muscle mass, a high percentage of body fat, and reduced well-being, but the development of penis [symptoma.com] Penile Carcinoma Among these variants is the exceedingly uncommon adenosquamous carcinoma (ASC), representing 1%-2% of all SCC of the penis. [ncbi.nlm.nih.gov] Large fungating squamous cell carcinoma of the penis Deirdre Mary Fanning, James Forde, Kevin O’Connor, Ted Mc Dermott Urology Department, St James’s Hospital, Dublin, Ireland [casereports.bmj.com] Prognosis of Cancer of the Penis (Squamous Cell Carcinoma of the Penis) Prognosis depends largely on the level of metastases and invasion. [myvmc.com] Diencephalic Syndrome I have a condition called Diencephalic syndrome, meaning I have an extremely large penis. [dearcupid.org] I have also heard that men with large penis's do have to be careful when substataining an erection as it uses a lot of blood to make it erect, which can cause alot further [dearcupid.org] A female reader, anonymous, writes (20 June 2007): It actually says right here on this website that a large penis is a clinical symptom of the disorder. http://www.orpha.net [dearcupid.org] Buschke-Lowenstein Tumor It is a slow growing tumor, but if not treated, can grow to a large size and ulcerate the penis; if it involves the perianal region, it can cause bleeding and abscesses. [symptoma.com] […] most commonly occurs near the penis or anus. [rarediseases.org] It becomes a large cauliflower-like, hyperkeratotic, verrucous mass that is… (More) National Institutes of Health [semanticscholar.org] Congenital Generalized Lipodystrophy Type 1 Upon further assessment, he had acromegaloid features with loss of fat deposition over whole body with prominent muscle bulk, protruding tongue, large penis and phlebomegaly [hkjpaed.org] Adults may have large hands and feet and a strong, square jawbone if their hormone balance is off and they've kept growing. [webmd.com] They could have larger than usual sex organs (clitoris and ovaries, penis and testicles). A woman might have irregular periods or none at all. [webmd.com] Agenesis of Uterus However, men’s penises are different sizes and a man who has a large penis may cause you some discomfort as he would any woman. [mrkh.org.uk] Penile Torsion Irritation of penis Large penis Lesion of penis Lesion penis Lichen planus of glans penis Lichen planus of penis Mass of penis Mass of prepuce Nocturnal erection of penis [icd9data.com] With a hidden or buried penis, the penis can be inside a large suprapubic mons. [nortonhealthcareprovider.com] Typical appearance of congenital concealed penis. [operationhappenis.org] Calcinosis Cutis Metastatica Here, we describe a patient who presented with advanced metastatic calcinosis cutis with multiple lesions of the large joints, neck, hands, and penis. [ncbi.nlm.nih.gov] Calcinosis cutis is an unusual disorder characterized by large calcium phosphate deposition into cutaneous and subcutaneous tissues. [ncbi.nlm.nih.gov] Here, we discuss the case of a 26-year-old man presenting with unusually advanced skin and joint calcification of the shoulders, neck, hand, and penis. [ncbi.nlm.nih.gov] Agenesis and aplasia of uterus However, men’s penises are different sizes and a man who has a large penis may cause you some discomfort as he would any woman. [mrkh.org.uk] Scrotal Elephantiasis B The penis is submerged within the scrotum. C The penis is partially submerged due to large bilateral hydroceles. [isradiology.org] Damage to the scrotum closed observed with the injuries, sdavljenia, accompanied by pain, hematoma (the latter sometimes reach large sizes, moving to the penis, perineum and [medicalency.com] After excising the large redundant, edematous scrotum, the penis was found and was dissected out with a circumcising incision around the corona and down to the base. [thefreelibrary.com] Uterine Cervical Aplasia and Agenesis However, men’s penises are different sizes and a man who has a large penis may cause you some discomfort as he would any woman. [mrkh.org.uk] Priapism In this case, there is a large amount of blood flowing into the penis. Priapism constitutes a true urologic emergency. [medindia.net] The injury causes the artery within the erectile body to rupture, and thus pump large amount of blood to the penis continuously. [ucsfhealth.org] Among mechanical causes of priapism are obstructions such as large blood clots or tumours in the penis. [britannica.com] Sarcoma of the Penis Several large studies have dmonstrated that smoking is associated with an increased incidence of squamous cell carcinoma of the penis. [health.am] Removing part or all of the penis If the cancer is large, or affecting too much of the penis, your surgeon may advise you to have part, or occasionally all, of the penis removed [macmillan.org.uk] If it has penetrated the deeper penile tissues or is large, surgery is the preferred treatment for most men. Radiation is an option but results are less certain. [healthcentral.com] Impotence The data from this monitor is then assessed to analyse how often erections occurred, how long they lasted, and how rigid and large the penis was during the erections. [healthengine.com.au] Erythroplasia of Queyrat These tumors do not metastasize, but may destroy the glans and prepuce, and become so large that a partial penis amputation is necessary. [oncolex.org] Several large studies have dmonstrated that smoking is associated with an increased incidence of squamous cell carcinoma of the penis. [health.am] cancer of the penis is epidemiologically uncommon in our parts but when they do come, they so late and reluctant to cooperate till even later. [bmj.com] Cowper Gland Carcinoma As the penis fills with blood, it becomes rigid and erect, which allows for penetration during sex. [my.clevelandclinic.org] The body or shaft: Shaped like a tube or cylinder, the body of the penis is made up of three internal chambers. [my.clevelandclinic.org] Inside these chambers there’s a special, sponge-like erectile tissue that contains thousands of large spaces that fill with blood when you’re sexually aroused. [my.clevelandclinic.org] Traumatic Urinary Bladder Rupture The penis rapidly loses its rigidity and a large bruise develops from the base of the penis to the head of the penis. A moderate amount of pain is associated with this. [healthcare.utah.edu] • When the Inf. fascia of UD is ruptured, urine can infiltrate the thigh or penis. 05-Jul-12 management of bladder injuries 22 23. PATHOPHYSIOLOGY... [slideshare.net] Usually patients have a lot of bleeding from the penis and a large bruise forms in the groin and perineum (the area between the anus and the scrotum). [healthcare.utah.edu] Peyronie Disease When the plaque is large enough, it causes painful curvature of the penis that may prevent intercourse. [med.unc.edu] It is worth noting that a large number of males who experience a penis injury do not go on to develop Peyronie's disease. [medicalnewstoday.com] When a man gets an erection, large amounts of blood flow into the erectile tissue, filling the blood channels which increases the penile size and gives the penis its rigidity [birminghamprostateclinic.co.uk] Abnormal Foreskin According to Esquivel Cabrera, 54, his penis and foreskin are so large that they inhibit him from working normally in part because no one will hire him, he told Mexican news [newsweek.com] […] fixation at the penoscrotal/penopubic junction resulting in buried or hidden appearance Buried penis may be normal in obese children with large suprapubic fat pad. [unboundmedicine.com] Conditions that increase the likelihood of the skin recovering the glans (e.g. buried penis, webbed penis, or large hydroceles or inguinal hernias that encroach on the penile [med.stanford.edu]