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33 Possible Causes for Large Penis, Severe Failure to Thrive

  • Donohue Syndrome

    Features include severe hyperinsulinism and fasting hypoglycemia, along with severe failure to thrive despite feeding.[] Affected females may have cystic ovaries and an abnormally enlarged clitoris/ breasts, while males may be afflicted with an abnormally large penis.[] DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features[]

  • Sexually Transmitted Disease

    As well they may experience severe forms of bacterial infections such as: conjunctivitis (pink eye) ear infections tonsillitis as well as delayed development failure to thrive[] […] of HPV particles are large enough that they cannot permeate the condom.[] They can appear on the anus, cervix, scrotum, penis, groin, or thigh.[]

  • Diencephalic Syndrome

    The neurologic signs frequently reported in patients with diencephalic syndrome were absent; however, severe failure to thrive was present.[] I have a condition called Diencephalic syndrome, meaning I have an extremely large penis.[] Because of the vague nature of symptoms, diagnosis is challenging and often delayed for several months, as other, more common causes of failure to thrive tend to be investigated[]

  • Congenital Isolated ACTH Deficiency

    Children are usually diagnosed because of failure to thrive, anorexia, mild dehydration and electrolyte abnormalities.[] […] or large clitoris.[] In newborns and infants it appears as a salt-wasting syndrome, characterized by severe hyponatremia, hyperkalemia, metabolic acidosis and prerenal azotemia associated with[]

  • Cutis Laxa, Autosomal Recessive

    […] to thrive, developmental delay, dysmorphism, osseous abnormality, and CNS manifestations.[] Glaucoma Posteriorly rotated ears Gingival overgrowth Striae distensae Congenital glaucoma Pointed chin Aortic aneurysm Tall stature Relative macrocephaly Hypoplasia of penis[] Several genetic defects have been found in patients and families with the clinical manifestations of ARCL II.[]

  • Sanjad-Sakati Syndrome

    They have typical physical features, namely; long narrow face, deep set small eyes, beaked nose, large floppy ears and micrognathia, severe failure to thrive and mild to moderate[] The boy had pinoscrotal hypoplasia and short penis which was later surgically corrected, while the girls had normal genitalia. All other systems were normal.[] Phenotypic features All the patients had severe failure to thrive, microcephaly, delayed motor milestones, mental retardation and learning difficulties.[]

  • CHARGE Syndrome

    Failure to thrive is often related to the severe sucking/swallowing problems.[] Underdeveloped genitals – Undescended testicles and small penis for males. Underdeveloped labia and uterus for females.[] Growth deficiency – Short size due to low growth hormone levels is common Facial features: Square face Broad forehead Arched eyebrows Large eyes Occasional droopy eyelids[]

  • Xeroderma Pigmentosum-Cockayne Syndrome Complex

    Children often suffer from severe failure to thrive and appear cachexic (severely underweight, often to the point of looking wasted).[] Facial anomalies, microphthalmia, cleft palate, small penis, and flexion contractures of large joints were noted. Cerebral MRI showed dysmyelination.[]

  • Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

    In the most severe "salt wasting" form of CAH ( 75% of severe or "classic" cases), concomitant aldosterone deficiency may lead to salt wasting with consequent failure to thrive[] In the CAH group, the BMI (SDS) and penis length were greater than those in the control group. No tumors were detected by palpation.[] Complete enzyme deficiency leads to classic Salt-Wasting (SW) is form presenting as failure to thrive, vomiting, hyperkalaemia, dehydration and shock.[]

  • Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome

    The spleen can be hypoplastic or aplastic and ascites has been noted in several infants. Failure to thrive is common and seizures have been reported.[] Females may have an abnormal heart-shaped uterus that is split into two instead of one large cavity, called a bicornuate uterus.[] Clinical Symptoms Feeding difficulties Failure to thrive Intrauterine growth restriction (IUGR) Severe/profound learning difficulties Recurrent infections Absences Seizures[]

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