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33 Possible Causes for Large Penis, Severe Failure to Thrive

  • Donohue Syndrome

    Features include severe hyperinsulinism and fasting hypoglycemia, along with severe failure to thrive despite feeding.[ncbi.nlm.nih.gov] Affected females may have cystic ovaries and an abnormally enlarged clitoris/ breasts, while males may be afflicted with an abnormally large penis.[symptoma.com] DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features[ncbi.nlm.nih.gov]

  • Sexually Transmitted Disease

    As well they may experience severe forms of bacterial infections such as: conjunctivitis (pink eye) ear infections tonsillitis as well as delayed development failure to thrive[herpes-coldsores.com] […] of HPV particles are large enough that they cannot permeate the condom.[web.archive.org] They can appear on the anus, cervix, scrotum, penis, groin, or thigh.[familydoctor.org]

  • Diencephalic Syndrome

    The neurologic signs frequently reported in patients with diencephalic syndrome were absent; however, severe failure to thrive was present.[ncbi.nlm.nih.gov] I have a condition called Diencephalic syndrome, meaning I have an extremely large penis.[dearcupid.org] Because of the vague nature of symptoms, diagnosis is challenging and often delayed for several months, as other, more common causes of failure to thrive tend to be investigated[symptoma.com]

  • Congenital Isolated ACTH Deficiency

    Children are usually diagnosed because of failure to thrive, anorexia, mild dehydration and electrolyte abnormalities.[file.scirp.org] […] or large clitoris.[clinicaladvisor.com] In newborns and infants it appears as a salt-wasting syndrome, characterized by severe hyponatremia, hyperkalemia, metabolic acidosis and prerenal azotemia associated with[file.scirp.org]

  • Cutis Laxa, Autosomal Recessive

    […] to thrive, developmental delay, dysmorphism, osseous abnormality, and CNS manifestations.[ncbi.nlm.nih.gov] Glaucoma Posteriorly rotated ears Gingival overgrowth Striae distensae Congenital glaucoma Pointed chin Aortic aneurysm Tall stature Relative macrocephaly Hypoplasia of penis[mendelian.co] Several genetic defects have been found in patients and families with the clinical manifestations of ARCL II.[ncbi.nlm.nih.gov]

  • Sanjad-Sakati Syndrome

    They have typical physical features, namely; long narrow face, deep set small eyes, beaked nose, large floppy ears and micrognathia, severe failure to thrive and mild to moderate[morressier.com] The boy had pinoscrotal hypoplasia and short penis which was later surgically corrected, while the girls had normal genitalia. All other systems were normal.[ncbi.nlm.nih.gov] Phenotypic features All the patients had severe failure to thrive, microcephaly, delayed motor milestones, mental retardation and learning difficulties.[emro.who.int]

  • CHARGE Syndrome

    Failure to thrive is often related to the severe sucking/swallowing problems.[orpha.net] Underdeveloped genitals – Undescended testicles and small penis for males. Underdeveloped labia and uterus for females.[cincinnatichildrens.org] Growth deficiency – Short size due to low growth hormone levels is common Facial features: Square face Broad forehead Arched eyebrows Large eyes Occasional droopy eyelids[cincinnatichildrens.org]

  • Xeroderma Pigmentosum-Cockayne Syndrome Complex

    Children often suffer from severe failure to thrive and appear cachexic (severely underweight, often to the point of looking wasted).[forgottendiseases.org] Facial anomalies, microphthalmia, cleft palate, small penis, and flexion contractures of large joints were noted. Cerebral MRI showed dysmyelination.[ncbi.nlm.nih.gov]

  • Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

    In the most severe "salt wasting" form of CAH ( 75% of severe or "classic" cases), concomitant aldosterone deficiency may lead to salt wasting with consequent failure to thrive[ncbi.nlm.nih.gov] In the CAH group, the BMI (SDS) and penis length were greater than those in the control group. No tumors were detected by palpation.[doi.org] Complete enzyme deficiency leads to classic Salt-Wasting (SW) is form presenting as failure to thrive, vomiting, hyperkalaemia, dehydration and shock.[austinpublishinggroup.com]

  • Growth Delay-Hydrocephaly-Lung Hypoplasia Syndrome

    The spleen can be hypoplastic or aplastic and ascites has been noted in several infants. Failure to thrive is common and seizures have been reported.[disorders.eyes.arizona.edu] Females may have an abnormal heart-shaped uterus that is split into two instead of one large cavity, called a bicornuate uterus.[rarediseases.org] Clinical Symptoms Feeding difficulties Failure to thrive Intrauterine growth restriction (IUGR) Severe/profound learning difficulties Recurrent infections Absences Seizures[bohring-opitz.org]

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