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402 Possible Causes for Late-Onset Spastic Paraplegia

  • X-Linked Spastic Paraplegia Type 2

    PMID: 27084214 [PubMed – in process] Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral[hspersunite.org.au] We report an SPG2 family in which 3 male members and a heterozygous female member were affected with spastic paraplegia characterized by relatively late onset and mild clinical[ncbi.nlm.nih.gov] Sivakumar K, Sambuughin N, Selenge B et al (1999) Novel exon 3B proteolipid protein gene mutation causing lateonset spastic paraplegia type 2 with variable penetrance in[link.springer.com]

  • Autosomal Dominant Spastic Paraplegia Type 10

    PMID: 27084214 [PubMed – in process] Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral[hspersunite.org.au] Seiji Kaji, Toshitaka Kawarai, Ryosuke Miyamoto, Hiroyuki Nodera, Lucia Pedace, Antonio Orlacchio, Yuishin Izumi, Ryosuke Takahashi and Ryuji Kaji, Late-onset spastic paraplegia[doi.org] Branco and Marcondes Cavalvante França Júnior, Cognitive dysfunction in hereditary spastic paraplegias and other motor neuron disorders, Dementia & Neuropsychologia, 10, 4[doi.org]

  • Spastic Paraplegia

    We identified a novel homozygous mutation in the splice site donor (SSD) of intron 30 (c.5866 1G A) in consanguineous Japanese SPG11 siblings showing late-onset spastic paraplegia[ncbi.nlm.nih.gov] Here, we have assessed molecular diagnosis by gene panel sequencing in 105 early and late-onset hereditary ataxia and spastic paraplegia probands, in whom extensive previous[ncbi.nlm.nih.gov]

  • Anxiety Disorder

    paraplegia, dementia Cerebrotendinous xanthomatosis Chronic, late onset Hallucinations, behavioural disturbances ( ) Tetraplegia, spastic paraplegia, cerebellar ataxia, polyneuropathy[ncbi.nlm.nih.gov] Metachromatic leucodystrophia Chronic, late onset Hallucinations, delusions, depression, cognitive decline Peripheral symptoms, ataxia GM2 gangliosidosis (Tay-Sachs disease[ncbi.nlm.nih.gov] ) Atypical psychosis Depression, delusions, behavioural disorders Spastic paraplegia X-linked adrenoleukodystrophy Variable Confusion, delusions Ataxia, abnormal movements[ncbi.nlm.nih.gov]

  • Spastic Paraparesis-Deafness Syndrome

    paraplegia Huntington's disease Hydrocephalus Hydrocephalus-stenosis of the aqueduct of Sylvius Intractable epilepsy Late-onset spastic paraplegia type 2 Major depressive[academic.oup.com] onset sensorineural deafness Gastroschisis Lipedema Hypotrichosis-lymphedema-telangiectasia syndrome Filippi syndrome Syndactyly type 3 Spastic paraplegia 31 Wrinkly skin[checkrare.com] […] neuropathy type II Dominant non-episodic cerebellar ataxia Familial periventricular heterotopia Gilles de la Tourette syndrome Hereditary progressive hearing loss Hereditary spastic[academic.oup.com]

  • Infantile-Onset Ascending Hereditary Spastic Paralysis

    PMID: 26671123 [PubMed – in process] Late-onset spastic paraplegia: Aberrant SPG11 transcripts generated by a novel splice site donor mutation.[sp-foundationorg.presencehost.net] Hentati A, Pericak-Vance MA, Lennon F, et al.: Linkage of the late onset autosomal dominant familial spastic paraplegia to chromosome 2p markers .[link.springer.com] MT-ATP6-related mitochondrial spastic paraplegia Machado-Joseph disease type 1 Machado-Joseph disease type 2 Machado-Joseph disease type 3 Macrocephaly-developmental delay[se-atlas.de]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Seiji Kaji, Toshitaka Kawarai, Ryosuke Miyamoto, Hiroyuki Nodera, Lucia Pedace, Antonio Orlacchio, Yuishin Izumi, Ryosuke Takahashi and Ryuji Kaji, Late-onset spastic paraplegia[doi.org] Late-onset hereditary spastic paraplegia with thin corpus callosum caused by a new SPG3A mutation. (Letter) J Neurol. 2011;258:1361–3. PubMed CrossRef Google Scholar 30.[link.springer.com] Branco and Marcondes Cavalvante França Júnior, Cognitive dysfunction in hereditary spastic paraplegias and other motor neuron disorders, Dementia & Neuropsychologia, 10, 4[doi.org]

  • Mental Disorder

    paraplegia, dementia Cerebrotendinous xanthomatosis Chronic, late onset Hallucinations, behavioural disturbances ( ) Tetraplegia, spastic paraplegia, cerebellar ataxia, polyneuropathy[ncbi.nlm.nih.gov] Metachromatic leucodystrophia Chronic, late onset Hallucinations, delusions, depression, cognitive decline Peripheral symptoms, ataxia GM2 gangliosidosis (Tay-Sachs disease[ncbi.nlm.nih.gov] ) Atypical psychosis Depression, delusions, behavioural disorders Spastic paraplegia X-linked adrenoleukodystrophy Variable Confusion, delusions Ataxia, abnormal movements[ncbi.nlm.nih.gov]

  • Osteosclerotic Metaphyseal Dysplasia

    The syndrome is characterized clinically by developmental delay of a progressive nature, hypotonia, elevated alkaline phosphatase, and late-onset spastic paraplegia.[ncbi.nlm.nih.gov] The syndrome is characterized by developmental delay of a progressive nature, hypotonia, elevated alkaline phosphatase, and late-onset spastic paraplegia 18 years ago.[ncbi.nlm.nih.gov]

  • Chronic Anxiety

    paraplegia, dementia Cerebrotendinous xanthomatosis Chronic, late onset Hallucinations, behavioural disturbances ( ) Tetraplegia, spastic paraplegia, cerebellar ataxia, polyneuropathy[ncbi.nlm.nih.gov] Metachromatic leucodystrophia Chronic, late onset Hallucinations, delusions, depression, cognitive decline Peripheral symptoms, ataxia GM2 gangliosidosis (Tay-Sachs disease[ncbi.nlm.nih.gov] ) Atypical psychosis Depression, delusions, behavioural disorders Spastic paraplegia X-linked adrenoleukodystrophy Variable Confusion, delusions Ataxia, abnormal movements[ncbi.nlm.nih.gov]

Further symptoms