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51 Possible Causes for Late Systolic Murmur, Thickening of the Mitral Valve Leaflets

  • Mitral Valve Prolapse

    On auscultation there may be a mid-systolic click and late systolic murmur. Reference: Criley et al. (1966).[] Two groups of patients were compared: those with thickening of the mitral-valve leaflets and redundancy (designated the classic form; n 319) and those without leaflet thickening[] Signs include a crisp mid-systolic click, followed by a late systolic murmur if regurgitation is present. Diagnosis is by physical examination and echocardiography.[]

  • Mitral Valve Disease

    The syndrome of mid-systolic click accompanying a systolic murmur was first described in the late 1800s, but it was in the early 1960s that its association with mitral regurgitation[] At surgery, nodular thickening of both valves and fusion of the posterior leaflet of the mitral valve were seen.[] […] by weakening and ballooning Etiology Rheumatic heart disease–thickening, rigidity, retraction of mitral valve leaflets; ASHD, HTN, left ventricular enlargement, connective[]

  • Mitral Valve Insufficiency

    […] isolated MR, did not differ significantly between pan-systolic and late-systolic murmur groups.[] Abstract Mitral valve insufficiency in rheumatic heart disease is often due to retracted posterior chordae and posterior leaflet thickening.[] valve prolapse were classified into two groups: those with thickening and redundancy of the mitral valve leaflets ("classic") and those without ("non classic") in an attempt[]

  • Familial Mitral Valve Prolapse

    Upon auscultation of an individual with mitral valve prolapse, a mid-systolic click, followed by a late systolic murmur heard best at the apex is common.[] Denny: The significance of late systolic murmurs. American Heart Journal, St. Louis, 1963, 66: 443. J. B. Barlow, C. K. Bosman, J. W. C.[] Parasternal long-axis echocardiogram recorded in a patient with bileaflet mitral valve prolapse and myxomatous thickening of the leaflets.[]

  • Chordae Tendinae Rupture

    systolic murmur that is best heard at the mitral region and may radiate to the axilla.[] Nickname: ldunbar Interpretation: torn chordae or possible vegetation on the posterior mitral valve leaflet.Moderate MR. Thickened mitral and aortic leaflets.[] MVP with MR causes a click with a late-systolic MR murmur.[]

  • Myxoid Transformation of the Mitral Valve

    Chordae tendineae rupture complicating the systolic click-late systolic murmur syndrome.[] […] orifice (disorder) Systolic anterior movement of mitral valve Systolic anterior movement of mitral valve (disorder) Thickened mitral leaflet Thickened mitral leaflet (disorder[] A murmur that lasts throughout the whole of systole is known as a holo-systolic murmur.[]

  • Papillary Muscle Disorder

    Functional papillary muscle insufficiency is characterized by an apical late systolic murmur and typically resolves without treatment.[] RECENT FINDINGS: Mitral valve abnormalities in hypertrophic obstructive cardiomyopathy include leaflet elongation and thickening and hypertrophy with anterior displacement[] Abstract PURPOSE OF REVIEW: This section reviews abnormalities of the mitral valve apparatus that are associated with hypertrophic obstructive cardiomyopathy.[]

  • Left Atrial Ball Valve Thrombus

    During TEE examination, mid esophageal 4-chamber view showed a severely stenotic mitral valve with thickened and calcified leaflet, severe LA dilatation with spontaneous echo[] Causes of mitral MDM other than MS- MR LA myxoma Ball valve thrombus VSD, PDA HCM Echocardiography Echocardiographic features of MS- Leaflet thickening Chordal thickening[] Figure 2: Midesophageal four chamber view shows a severely stenotic mitral valve with thickened and calcified leaflets and associated severe left atrial dilatation with spontaneous[]

  • Myxomatous Mitral Valve Prolapse 3

    systolic murmur that is best heard at the mitral region and may radiate to the axilla.[] […] of an abnormally thickened mitral valve leaflet into the left atrium during systole.[] Late systolic murmurs and non-ejection (“mid-late”) systolic clicks. An analysis of 90 patients. Br Heart J. 1968;30:203–18. 17.[]

  • Myxomatous Mitral Valve Prolapse 2

    In the 1960s, Reid 7 and Barlow and colleagues 1 proposed that mid to late systolic clicks and apical late systolic murmurs were of mitral valvar origin.[] Definition A form of mitral valve prolapse, a valvular hearth disease characterized by abnormally elongated and thickened mitral valve leaflets, that typically show myxomatous[] Thickened ( 5 mm), redundant mitral valve leaflets are thought to indicate more extensive myxomatous degeneration and greater risk of endocarditis and mitral regurgitation[]

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