LDL Decreased: Causes & Reasons

Possible Causes for LDL Decreased

Decreased production rates of apoB have been demonstrated in vivo in FHBL heterozygotes. [ncbi.nlm.nih.gov]

CONCLUSIONS: Decreasing levels of LDL cholesterol are associated with decreasing levels of hemostatic risk factors. [ncbi.nlm.nih.gov]

Decreased plasma LDL-C and apoB were noted in the father (34 and 40 mg/dl, respectively), as well as several other family members. [ncbi.nlm.nih.gov]

Lecithin Acyltransferase Deficiency

CONCLUSIONS: The decreased LDL in LCAT-def is attributable to an increased catabolism caused by a rapid catabolism of abnormal LDL and an upregulation of LDL receptor pathway [ncbi.nlm.nih.gov]

[…] the unesterified cholesterol and lecithin of the VLDL and LDL are decreased. [jci.org]

Its deficiency produces a decrease in the synthesis of both LDL and HDL but with an Apo A-I not as low as seen in TD (< 40 mg/dL). [endocrinologiapediatrica.org]

Abetalipoproteinemia

Laboratory Acanthocytosis, decreased VLDL-cholesterol, decreased LDL-cholesterol, absent apolipoprotein B-48 and B-100. [medical-dictionary.thefreedictionary.com]

Lab Acanthocytosis, decreased VLDL-cholesterol, decreased LDL-cholesterol, absent apoB when homozygous. Management Medium-chain TGs, water-miscible vitamin E. [medical-dictionary.thefreedictionary.com]

Diagnostic signs include lipid-laden enterocytes on intestinal biopsy, acanthocytes, and decreased plasma cholesterol and LDL levels. [picmonic.com]

Hypobetalipoproteinemia Familial 2

Results: Both the proband and his son, who had the same mutation, had low LDL cholesterol and decreased ApoB, but an increased small-dense LDL level. [research.manchester.ac.uk]

LDL cholesterol concentration ; Hypotriglyceridemia Associated Genes ANGPTL3 (Withdrawn symbols: ANGPT5 ) Mouse Orthologs Angptl3 Source OMIM:605019 (names, synonyms, disease [mousephenotype.org]

Affiliated tissues include liver, and related phenotypes are hypotriglyceridemia and decreased ldl cholesterol concentration Disease Ontology : 12 A hypobetalipoproteinemia [malacards.org]

Psyllium

The decreases in LDL and HDL particles were in the small subfractions. [ncbi.nlm.nih.gov]

Similarly, low density lipoprotein (LDL)-cholesterol decreased from 174+/-34 to 162+/-31mg/dl during the study. [ncbi.nlm.nih.gov]

[…] that fiber reduced LDL cholesterol concentration without decreasing the number of LDL particles. [ncbi.nlm.nih.gov]

Gaucher Disease

Gaucher's disease Acid beta-glucosidase Specialty Endocrinology Gaucher's disease or Gaucher disease () (GD) is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs. The disorder is characterized by bruising, fatigue, anemia, low blood[…] [en.wikipedia.org]

Combined Hyperlipidemia

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

Statins increased LDL size, decreased LDL(-), and lowered Lp-PLA2 in HDL from HTG. [mdpi.com]

Rosuvastatin at 5 and 40 mg/day decreased LDL cholesterol by 44 and 54% (both P < 0.0001), triacylglycerol by 14% (ns) and 35% (P < 0.01), apoB by 30 and 36% (both P < 0.0001 [ncbi.nlm.nih.gov]

Cholesterol-Ester Transfer Protein Deficiency

The percent transfer of CSA from LDL to HDL was significantly decreased in the presence of TP2. [jpet.aspetjournals.org]

[…] in LDL-cholesterol except for dalcetrapib. [journals.lww.com]

However, the CETP inhibitor torcetrapib was found to increase cardiovascular events, since HDL increased and LDL decreased substantially 10, 11. [ijpsr.com]

Hyperlipoproteinemia Type 4

Hypothyroidism Serum LDL levels are raised in hypothyroidism because receptor mediated LDL catabolism is decreased. [diapedia.org]

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

(600 )mg Fenofibrate(200 mg) Decrease TG Decrease LDL Increase HDL Nicotinic acid derivatives Niacin(2-6 gm) Decrease TG Decrease LDL Increase HDL Cholesterol absorption [biomedpharmajournal.org]

Homozygous Familial Hypercholesterolemia

Pre-procedural LDL-C decreased significantly with weekly versus biweekly LDL-A. [ncbi.nlm.nih.gov]

Low-density lipoprotein (LDL) apheresis (LA) is a reliable method to decrease LDL-C concentrations and remains the gold standard therapy in homozygous familial hypercholesterolemia [ncbi.nlm.nih.gov]

[…] aphaeresis to remove LDL from the serum to decrease the levels [1]. [hindawi.com]

Hyperlipoproteinemia Type 5

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

They may also be caused by the decreased clearance of LDL. Prevalence in the population is 10%. [en.wikipedia.org]

Familial Hyperlipidemia

Medications Used to Treat Hyperlipidemia in Children and Adolescents Drug class Action Primary use Adverse effects Comments Bile acid sequestrants Decrease LDL cholesterol [aafp.org]

One month later, the arthritis had improved, the total and LDL cholesterol levels had decreased to 333 and 258 mg per deciliter (8.6 and 6.7 mmol per liter), respectively, [nejm.org]

Tests will show: Increased LDL cholesterol Decreased HDL cholesterol Increased triglycerides Increased apolipoprotein B100 Genetic testing is available for one type of familial [medlineplus.gov]

Familial Hypercholesterolemia Type 1

Patients with heFH had more LDL-c decrease than those with hoFH (56% vs 38%). [ncbi.nlm.nih.gov]

After 12 months of treatment with statin and resin, his LDL-C decreased from 446 to 220 mg/dL, thickening of the Achilles tendons decreased from 1618 mm to 13 mm, and hyperplasia [ncbi.nlm.nih.gov]

Thereafter, their LDL cholesterol levels decreased rapidly, and the patients were successfully weaned from LDL apheresis. [ncbi.nlm.nih.gov]

Familial Hypercholesterolemia Type 2

[…] receptors on liver (LDL decreases) How does Bile acid sequestrans work? [brainscape.com]

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

They may also be caused by the decreased clearance of LDL. Prevalence in the population is 10%. [en.wikipedia.org]

Familial Combined Hyperlipidemia

Statin drugs, especially the synthetic statins ( atorvastatin and rosuvastatin ), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

Opposite changes in LDL size were seen with the 2 treatments, with increased mean LDL particle diameter with atorvastatin, and decreased diameter with pravastatin, and significant [ncbi.nlm.nih.gov]

LDL receptor and increased ApoB. [en.wikipedia.org]

Heterozygous Familial Hypercholesterolemia

Low-density-lipoprotein (LDL) cholesterol decreased 55 per cent with colestipol and niacin, whereas highdensity-lipoprotein (HDL) cholesterol increased. [nejm.org]

By reducing hepatic cholesterol synthesis, these drugs enhance LDL receptor activity in the liver, which, in turn, increases LDL catabolism and decreases LDL-cholesterol production [ommbid.mhmedical.com]

A ≥ 50% decrease in LDL-C over the observation period was an additional outcome measure. [termedia.pl]

Familial Hypercholesterolemia

Patients with heFH had more LDL-c decrease than those with hoFH (56% vs 38%). [ncbi.nlm.nih.gov]

After 10 months of treatment with pitavastatin (2 mg/day) and ezetimibe (10 mg/day), LDL-C decreased from 595 mg/dL to 267 mg/dL in the boy and from 530 mg/dL to 182 mg/dL [ncbi.nlm.nih.gov]

Hyperlipidemia

Patients allocated to simvastatin had a mean difference in LDL cholesterol of −1 mmol/l, with decreases in total and cardiovascular mortality of 12% and 17% and decreases [ncbi.nlm.nih.gov]

At 12 weeks, mean LDL-C levels decreased from 114.6 mg/dL to 105.5 mg/dL (p = 0.11). [acc.org]

The mean decrease in LDL cholesterol on 10 mg daily was 18.2% which was accompanied by small but significant increases in HDL cholesterol and decreases in serum triglyceride [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 1

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

They may also be caused by the decreased clearance of LDL. Prevalence in the population is 10%. [en.wikipedia.org]

Types Familial combined hyperlipidemia (FCH) is the familial occurrence of this disorder, probably caused by decreased LDL receptor and increased ApoB. [en.wikipedia.org]

Hyperlipoproteinemia Type 3

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

Elevated LDL only Bile Acid Sequestrants, Statins, Niacin Type IIb Combined hyperlipidemia Decreased LDL receptor and Increased ApoB Elevated LDL and VLDL and Triglycerides [bionity.com]

Hyperlipoproteinemia

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

They may also be caused by the decreased clearance of LDL. Prevalence in the population is 10%. [en.wikipedia.org]

Hypercholesterolemia

Traditionally, risk factors for cardiovascular disease in adults have included elevated levels of low-density lipoprotein (LDL), decreased levels of high-density lipoprotein [pediatricheartspecialists.com]

In both patients, serum total and LDL-cholesterol decreased dramatically in two months and progressively normalized. [ncbi.nlm.nih.gov]

pravastatin 20-40 mg, and simvastatin 10 mg could decrease LDL-C by 20-30%. [ncbi.nlm.nih.gov]

Primary Bile Acid Malabsorption

Primary bile acid malabsorption (PBAM) is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. The molecular basis of PBAM is unknown, and several conflicting mechanisms have been postulated.[…] [ncbi.nlm.nih.gov]

Anemia in Chronic Kidney Disease

[…] in BUN, SCr, AST, ALT, cholesterol, triglyceride, HDL, or to decrease LDL. [cochranelibrary.com]

LDL. [cochranelibrary.com]

There was insufficient evidence to discern if oxymetholone plus rHuEPO decreased BUN, SCr, cholesterol, TG, LDL and adverse events. [cochranelibrary.com]

Hyperlipidemia due to Hepatic Triglyceride Lipase Deficiency

High hepatic lipase activity is associated with accumulation of small dense LDL and decreases in HDL 2 -C, changes that increase risk for early atherosclerosis. [ommbid.mhmedical.com]

However, the consequent decrease in LDL may cause an increase in VLDL in patients with hyperlipidemia. [lecturio.com]

Both decrease VLDL and LDL in some by acting as up-regulators for the transcriptions of LPL and other enzymes involved in the hydrolysis of lipids. [lecturio.com]

Subclinical Hypothyroidism

Regarding the LDL cholesterol, a greater decrease by −0.62 mmol/L (with a CI between −0.90 and −0.35 mmol/L) was obtained with levothyroxine treatment than with control. [ncbi.nlm.nih.gov]

Our study showed a decrease in LDL cholesterol twice compared to that reported in Helsinki Heart Study (14% vs 7%), which could be translated to further cardiovascular risk [ncbi.nlm.nih.gov]

Throughout the meta-analysis we found a statistically significant decrease on total and LDL cholesterol with levothyroxine treatment compared with the placebo group, but not [ncbi.nlm.nih.gov]

Dyslipidemia

Despite dramatic 9-month weight gain (68 lb total), LDL-C and HDL-C reached goal and Lp(a) levels decreased by 33% (204 nmol/L) after niacin ER maximization. [ncbi.nlm.nih.gov]

BACKGROUND: Dyslipidemia, an increased level of total cholesterol (TC), triglycerides (TG), low-density-lipoprotein cholesterol (LDL-C) and decreased level of high-density-lipoprotein [ncbi.nlm.nih.gov]

Patients allocated to simvastatin had a mean difference in LDL cholesterol of −1 mmol/l, with decreases in total and cardiovascular mortality of 12% and 17% and decreases [ncbi.nlm.nih.gov]

Chitotriosidase Deficiency

This probably reflects the significant decrease of total cholesterol and LDL-C during the first 48 hours after an acute vascular event29 and the lack of significant correlation [ahajournals.org]

Total cholesterol and LDL-C were significantly lower in ATS versus control subjects. [ahajournals.org]

[…] and BMI were significantly higher in the IHD group than in control group; age was significantly lower, and no statistical differences were observed in total cholesterol, LDL-C [ahajournals.org]

Cholestyramine - Teratogenic Agent

Definition (Fenofibrate) VLDL - decreased LDL - unchanged/decreased HDL - increased TG - decreased Term What drug can cause Azotemia? [flashcardmachine.com]

Biliary excretion. don't affect LDL-R decreased LDL decreased HDL 20-30% diarrhea QT tract lengthening (don't associate to class I or class III antiarrhythmic drugs, tricyclic [ufrgs.br]

[…] the hepatic stores of cholesterol Clinical use primarily decreases LDL primarily used in combination with a statin Toxicity rare hepatotoxicity when used in combination with [medbullets.com]

Fat-Restricted Diet

Decrease in saturated fat intake was only marginally related to decrease in LDL cholesterol. [en.wikipedia.org]

Both LDL and HDL decreased in the low-fat group only. 22. Krebs NF, et al. [healthline.com]

LDL decreased in HP and HC diets. 25% of those on HF diet, 13% of HC diet, and 3% of HP diet showed >10% increase in LDL Aude et al. (2004). [awlr.org]