685 Possible Causes for LDL Increased

  • Niemann-Pick Disease Type B

    LDL cholesterol Increased triglycerides Decreased HDL cholesterol Etiology Caused by mutations in the acid lysosomal sphingomyelin phosphodiesterase-1 gene (SMPD1) (MIM.607608[humpath.com] […] plasma triglycerides Increased serum triglycerides Increased triglycerides [ more ] 0002155 Increased circulating low-density lipoprotein levels Increased circulating LDL[rarediseases.info.nih.gov] LDL-c, and hypertriglyceridemia) Plain radiograph chest reticulonodular pattern which usually starts in the lower lobes calcified micronodules skeletal short stature with[radiopaedia.org]

  • Familial Hypercholesterolemia

    Serum levels of TC and LDL increase massively. Physiologically, serum LDL levels are primarily regulated by hepatocytic uptake and LDL degradation.[symptoma.com] Each copy of the R3527Q T allele was associated with a 74.9 mg/dL increase in LDL-C.[diabetes.diabetesjournals.org] Anabolic steroids may increase LDL-C levels. Cyclosporine, used to suppress the immune system, can raise LDL-C levels. Thiazide diuretics may increase LDL-C levels.[clinicaladvisor.com]

  • Cholesterol Ester Storage Disease

    This results in an increase in the number and activity of LDL receptors on the hepatocyte membrane, and the rate of LDL catabolism increases.[lipidworld.biomedcentral.com] This explains the laboratory results detailed above: permanent hypercholesterolemia, increased LDL cholesterol and decreased HDL cholesterol.[symptoma.com] In a CESD patient, the increased clearance of CE-trafficking LDL has the potential, theoretically, to increase cellular CE, adding to hepatotoxicity.[raredr.com]

  • Wolman Disease

    SREBP in this free cholesterol deficiency scenario also causes increased endocytosis by the LDL receptors and enhanced production of apolipoprotein B (ApoB) and very-low-density[symptoma.com] In LAL-D, the cellular uptake of LDL-C has been shown to increase in LAL-deficient fibroblasts, while the uptake of Apo B was normal in a patient with LAL-D.[uspharmacist.com] CESD may initially be confused with familial hypercholesterolemia because of increased serum concentration of total cholesterol and LDL; mutation of LDLR, APOB, or PCSK9 accounts[bredagenetics.com]

  • Homozygous Familial Hypercholesterolemia

    Mutations in this gene cause a reduction in LDLR activity and are associated with decreased clearance of LDL particles and increased LDL‐C levels.[intechopen.com] They have been shown to lower LDL cholesterol and increase HDL cholesterol significantly. Thye also may have a role in helping to treat people with HoFH.[heartuk.org.uk] Residual LDL receptor activity is associated with the severity of LDL-c increase and propensity for early CV disease [6,7].[pace-cme.org]

  • Anabolic Steroid

    Additional side effects include hair growth, hair loss , infertility , changes in libido, decreases in HDL-cholesterol ("good" cholesterol) and increases in LDL-cholesterol[medicalnewstoday.com] […] metabolism, including lowered high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL).[emedicine.medscape.com] […] in LDL; decreases in HDL • High blood pressure • Heart attacks • Enlargement of the heart’s left ventricle Liver • Cancer • Peliosis hepatitis • Tumors Skin • Severe acne[physio-pedia.com]

  • Coronary Artery Disease

    Low-density lipoprotein (LDL), commonly called “bad” cholesterol, leads to increased cholesterol levels.[phlbi.org] Several factors can increase your chance of coronary artery disease, including: high LDL cholesterol, high triglycerides levels and reduced HDL cholesterol high blood pressure[barnesjewish.org] […] your blood while increasing the levels of "good" (HDL) cholesterol.[medbroadcast.com]

  • Arteriosclerosis

    High stress: A fast-paced, High-stress lifestyle increases blood pressure and places undue pressure on the heart and arteries.[holisticonline.com] High levels of LDL cholesterol (the 'bad' cholesterol) in the blood.[netdoctor.co.uk] Nicotinic acid or niacin: A water-soluble B vitamin that significantly increases HDL cholesterol (good cholesterol) and reduces LDL cholesterol (bad cholesterol).[emedicinehealth.com]

  • Diabetic Nephropathy

    Using multivariate analysis considering dura­tion of diabetes, BMI, sex, smoking, alcohol consumption of more than 10 years duration, total cholesterol, triglycerides, HDL, LDL[sjkdt.org] With increasing stage of CKD a significant increase in prevalence of proliferative retino­pathy, neuropathy and coronary artery disease was found.[sjkdt.org]

  • Heat Stroke

    The danger of dehydration and heat stroke Dehydration and heat stroke are two very common heat-related diseases that can be life-threatening if left untreated. What is dehydration? Dehydration can be a serious heat-related disease. It is also a dangerous side effect of diarrhea, vomiting, and fever. Children[…][hopkinsmedicine.org]

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