LDL Increased: Causes & Reasons

Possible Causes for LDL Increased

Addition of 100 mg cholesterol per day to the diet increases total cholesterol with a 1.9 mg/dL increase in LDL cholesterol and a 0.4 mg/dL increase in HDL cholesterol. [ncbi.nlm.nih.gov]

Abstract: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of plasma low density lipoproteins (LDL) and an increased risk [doi.org]

High levels of “bad” LDL cholesterol — especially small, dense oxidized LDL — have been linked to increased risk of heart disease. [healthline.com]

Familial Hypercholesterolemia Type 1

LDL, decreased HDL, increased triglycerides Alcohol excess Increased triglycerides, increased HDL Cholestasis Increased LDL, increased total chol Diabetes Mellitus Hyperlipidaemia [diapedia.org]

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

Increased chylomicrons falsely lower calculated LDL Small dense LDL particles are associated with increased risk of what disease(s)? What is the function of cholesterol? [brainscape.com]

Heterozygous Familial Hypercholesterolemia

Low-density-lipoprotein (LDL) cholesterol decreased 55 per cent with colestipol and niacin, whereas highdensity-lipoprotein (HDL) cholesterol increased. [nejm.org]

By reducing hepatic cholesterol synthesis, these drugs enhance LDL receptor activity in the liver, which, in turn, increases LDL catabolism and decreases LDL-cholesterol production [ommbid.mhmedical.com]

LDL receptor expression is partly – half the equation is how do you increase the number of LDL receptors that you make from that one good gene? [chrismasterjohnphd.com]

Familial Hypercholesterolemia Type 2

From More Specific Terms familial combined hyperlipidemia Etiology familial form ( familial combined hyperlipidemia ) defect in LDL receptor Laboratory increase in LDL cholesterol [anvita.info]

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

[…] production of VLDL - VLDL matures to LDL - certain increase in LDL causes VLDL increase leading to hyperCHOLESTEROLemia and hyperTRIGLYCERIDEmia respectively dys beta lipoprotein [quizlet.com]

Homozygous Familial Hypercholesterolemia

This mutation can lead to increased serum LDL, and subsequently to premature coronary artery disease. [ncbi.nlm.nih.gov]

Brief Define Diagnosis Treatment Prognosis  A genetic disorder of lipoprotein metabolism  Rise of LDL increased risk for premature CVD   Clinical features  Family history [slideshare.net]

[…] in extremely elevated plasma LDL cholesterol (LDL-C) and increased risk of atherosclerosis, coronary heart disease, and premature death. [ncbi.nlm.nih.gov]

Familial Hypercholesterolemia

Each copy of the R3527Q T allele was associated with a 74.9 mg/dL increase in LDL-C. [diabetes.diabetesjournals.org]

Serum levels of TC and LDL increase massively. Physiologically, serum LDL levels are primarily regulated by hepatocytic uptake and LDL degradation. [symptoma.com]

Anabolic steroids may increase LDL-C levels. Cyclosporine, used to suppress the immune system, can raise LDL-C levels. Thiazide diuretics may increase LDL-C levels. [clinicaladvisor.com]

Growth Hormone Deficiency

[…] in rate of fracture in middle age and beyond changes in blood cholesterol concentrations (increase in LDL and decrease in HDL) excessive tiredness anxiety and depression [pituitary.org.uk]

compared to the control group (median increase in LDL-CH, CH and TG were 0.1 mmol/l, 0.1 mmol/l and 0.3mmol/l, respectively). [ncbi.nlm.nih.gov]

[…] feelings of social isolation reduction in 'quality of life' increased sensitivity to cold or heat [pituitary.org.uk]

Arteriosclerosis

These fats actually help to lower LDL and increase levels of HDL the good cholesterol. These fats come from oily fish such as salmon, tuna and trout. [avogel.ca]

Risk factors include high BP, smoking, diabetes (DM) and increased LDL. Our last topic will be on hyperlipidemia and drugs that combat this. [youtube.com]

Smoking increases LDL and decreases HDL; it also promotes vasoconstriction, which is particularly dangerous in arteries already narrowed by atherosclerosis. [msdmanuals.com]

Cholesterol Ester Storage Disease

This explains the laboratory results detailed above: permanent hypercholesterolemia, increased LDL cholesterol and decreased HDL cholesterol. [symptoma.com]

In a CESD patient, the increased clearance of CE-trafficking LDL has the potential, theoretically, to increase cellular CE, adding to hepatotoxicity. [raredr.com]

This results in an increase in the number and activity of LDL receptors on the hepatocyte membrane, and the rate of LDL catabolism increases. [lipidworld.biomedcentral.com]

Coronary Atherosclerosis

Increased LDL levels were observed over time in patients with the -7673G>A polymorphism of the ApoB gene. [ncbi.nlm.nih.gov]

But trans fatty acids not only increase LDL cholesterol levels, they also reduce HDL cholesterol levels. [web.archive.org]

Lose Weight Obesity results not only in increased LDL cholesterol but also in reduced HDL cholesterol. [heartdisease.about.com]

Niemann-Pick Disease Type B

LDL cholesterol Increased triglycerides Decreased HDL cholesterol Etiology Caused by mutations in the acid lysosomal sphingomyelin phosphodiesterase-1 gene (SMPD1) (MIM.607608 [humpath.com]

[…] plasma triglycerides Increased serum triglycerides Increased triglycerides [ more ] 0002155 Increased LDL cholesterol concentration Increased circulating LDL level Increased [rarediseases.info.nih.gov]

LDL-c, and hypertriglyceridemia) Plain radiograph chest reticulonodular pattern which usually starts in the lower lobes calcified micronodules skeletal short stature with [radiopaedia.org]

Wolman Disease

LDL-C synthesis. [symptoma.com]

In LAL-D, the cellular uptake of LDL-C has been shown to increase in LAL-deficient fibroblasts, while the uptake of Apo B was normal in a patient with LAL-D. [uspharmacist.com]

Additionally, LDL decreased in two patients from 118.8 mg/dL at baseline by a median 47.5% at 48 weeks and HDL increased in three other patients from 9.4 mg/dL at baseline [healio.com]

Anabolic Steroid

LDL goes up. This predisposes people to an increased risk of heart attack. [medicalnewstoday.com]

The most prominent changes are concomitant elevations of LDL and decreases of HDL, effects that increase the risk of coronary artery disease. [ncbi.nlm.nih.gov]

[…] metabolism, including lowered high-density lipoprotein (HDL) and increased low-density lipoprotein (LDL). [emedicine.medscape.com]

Combined Hyperlipidemia

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

In affected patients, fibrate therapy either increases or has no effect on the serum LDL-cholesterol level. [endocrinenews.endocrine.org]

Characteristic lipoprotein abnormalities include increases in apoB with variable manifestations of hyperlipidemia, including hypertriglyceridemia and/or increases in LDL cholesterol [ahajournals.org]

Hyperlipidemia

It may greatly heighten the risk of atherosclerosis with a raised LDL-c, triglyceride-rich lipoprotein excess, and increased lipoprotein(a) as well as lowered HDL-c. [ncbi.nlm.nih.gov]

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

Increase removal of LDL particles. [biomedpharmajournal.org]

Familial Hyperlipidemia

[…] clearance of LDL; increased production of VLDL Increased levels of LDL and VLDL Increased cholesterol and TGs Increased risk of atherosclerosis and coronary disease Familial [quizlet.com]

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

In patients with type 4 hyperlipoproteinemia, gemfibrozil alone reduced triglycerides by 40%, raised HDL-cholesterol by 26%, and increased LDL-cholesterol levels by 29%. [annals.org]

Familial Combined Hyperlipidemia

The proband and 9 of 18 relatives had elevated plasma levels of low density lipoprotein (LDL) B protein; of these nine relatives, four had elevated LDL of increased density [ncbi.nlm.nih.gov]

OBJECTIVE: Insulin resistance is associated with increased triglyceride levels, low high-density lipoprotein cholesterol, small dense low-density lipoprotein (LDL), and increased [ncbi.nlm.nih.gov]

Opposite changes in LDL size were seen with the 2 treatments, with increased mean LDL particle diameter with atorvastatin, and decreased diameter with pravastatin, and significant [ncbi.nlm.nih.gov]

Hyperlipoproteinemia Type 5

Increase removal of LDL particles. [biomedpharmajournal.org]

Hypo-alphalipoprotenemia memorize Question Answer increased lipoprotein is chylomicron I increased lipoprotein is LDL IIa increased lipoprotein is LDL and VLDL IIb INcreased [memorize.com]

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

Hyperlipoproteinemia Type 4

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

Hyperlipoproteinemia Type 3

[…] cholesterol concentration Increased circulating LDL level Increased LDL cholesterol [ more ] 0003141 30%-79% of people have these symptoms Corneal arcus 0001084 Diabetes [rarediseases.info.nih.gov]

From More Specific Terms familial combined hyperlipidemia Etiology familial form ( familial combined hyperlipidemia ) defect in LDL receptor Laboratory increase in LDL cholesterol [anvita.info]

Nodular Glomerulosclerosis

Advertisement Advertisement Page views in 2018: 6,138 Page views in 2019 to date: 2,885 Cite this page: Sangle N. Diabetic glomerulosclerosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneydiabetes.html. Accessed March 31st, 2019. Definition / general Diffuse capillary basement membrane[…] [pathologyoutlines.com]

Hyperlipoproteinemia Type 1

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

LDL and HDL are two types of lipoproteins, with increased LDL levels correlating with problems such as heart disease. [healthfully.com]

Hyperlipoproteinemia

Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type [usmleforum.com]

LDL-cholesterol and lipoprotein(a) (Lp(a)) levels, are severe risk factors for atherosclerosis. [ncbi.nlm.nih.gov]

Increased VLDL apoB/LDL apoB ratio Increased VLDL apoB/total apoB Increased TG/apoB ratio Figure 1: The ApoB Diagnostic Algorithm Sequential steps involving apoB, triglyceride [acc.org]

Cholesterol-Ester Transfer Protein Deficiency

Plasma VLDL levels correlate with increased density and decreased size of LDL ( 22, 23 ). [care.diabetesjournals.org]

Thus, the mean particle size of both HDL and LDL was significantly increased by torcetrapib. [nejm.org]

[…] more atherogenic small LDL subfraction and increased levels of the less atherogenic large LDL [ 43 Brunzell JD, Hokanson JE. [benthamopen.com]

Hypobetalipoproteinemia

The increased in vivo catabolism of apoB-87 LDL was paralleled in vitro by a 2.5-fold increased ability of these particles to inhibit the uptake and degradation of normal [ncbi.nlm.nih.gov]

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a central player in the regulation of cholesterol homeostasis, increasing the low-density lipoprotein (LDL) receptor [ncbi.nlm.nih.gov]

As LDL cholesterol increased, there was a significant increase in the levels of the hemostatic risk factors, with the exception of von Willebrand factor antigen. [ncbi.nlm.nih.gov]

Hypertriglyceridemia

LDL-C levels increased by 21% to 45% except in studies of the icosapent ethyl, which found a decrease in LDL-C of 5%. [cmecorner.com]

Abstract Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) [ncbi.nlm.nih.gov]

Anemia in Chronic Kidney Disease

LDL. [cochranelibrary.com]

There was limited evidence to indicate that oxymetholone may increase Hb, HCT, plasma albumin, AST, and ALT; and decrease HDL, cholesterol, triglyceride, and LDL. [cochranelibrary.com]

Evidence was insufficient to determine if oxymetholone had an effect in decreasing BUN, SCr, and LDL or in increasing plasma total protein, prealbumin, and transferrin. [cochranelibrary.com]

Dyslipidemia

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor [en.wikipedia.org]

Summary: refers to one of the following disorders: increased total choleserol, increased LDL-C, increased triglyceride and reduced HDL-C. [tapchiyhocduphong.vn]

High LDL cholesterol increases the risk of cardiovascular disease, especially coronary heart disease. [youtube.com]

Hyperlipidemia due to Hepatic Triglyceride Lipase Deficiency

This patient developed hypercholesterolemia with an increase in both LDL and HDL. An increased proportion of lighter LDL (LDL1) and HDL (HDL2) was noted. [ncbi.nlm.nih.gov]

They reduce LDL cholesterol by up to 60% and produce small increases in HDL and modest decreases in TGs. [merckmanuals.com]

In addition to lowering LDL concentrations, treatment was associated with increased LDL buoyancy and reduced hepatic lipase activity. [ajcn.nutrition.org]

Subclinical Hypothyroidism

This suggests that increases in total and LDL cholesterol in subclinical hypothyroidism are, to an extent, related to increased TSH levels, and these predict the degree of [ncbi.nlm.nih.gov]

[…] hormones replacement, especially regarding total and LDL cholesterol reduction and overall left cardiac function. [ncbi.nlm.nih.gov]

[…] cholesterol is strongly associated with increasing rates of atherosclerosis, cardiovascular disease, stroke and other vascular complications (37). [ncbi.nlm.nih.gov]