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134 Possible Causes for LDL Increased, Tendon Xanthomas

  • Heterozygous Familial Hypercholesterolemia

    Sixty-two patients had positive physical examination findings for Achilles tendon xanthomas.[ajronline.org] Low-density-lipoprotein (LDL) cholesterol decreased 55 per cent with colestipol and niacin, whereas highdensity-lipoprotein (HDL) cholesterol increased.[nejm.org] LDL receptor expression is partly – half the equation is how do you increase the number of LDL receptors that you make from that one good gene?[chrismasterjohnphd.com]

  • Familial Hypercholesterolemia

    The case presented here is of a 48-year old male with large tendon xanthomas attributable to CTX.[ncbi.nlm.nih.gov] LDL, decreased HDL, increased triglycerides Alcohol excess Increased triglycerides, increased HDL Cholestasis Increased LDL, increased total chol Diabetes Mellitus Hyperlipidaemia[diapedia.org] BACKGROUND AND AIMS: The effect of LDLc lowering with PCSK9 antibodies on tendon xanthomas (TX) is unknown.[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    Xanthomas are noted commonly on the Achilles tendons and metacarpal phalangeal extensor tendons of the hands.[emedicine.medscape.com] Abstract: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of plasma low density lipoproteins (LDL) and an increased risk[doi.org] High levels of “bad” LDL cholesterol — especially small, dense oxidized LDL — have been linked to increased risk of heart disease.[healthline.com]

  • Homozygous Familial Hypercholesterolemia

    The condition is characterized by exceptionally high LDL cholesterol levels, cutaneous and tendon xanthomas, and valvular and supravalvular stenosis, and accelerated atherosclerosis[ncbi.nlm.nih.gov] This mutation can lead to increased serum LDL, and subsequently to premature coronary artery disease.[ncbi.nlm.nih.gov] Xanthomas The high cholesterol level may result in the build-up of cholesterol deposits in the skin and tendons as well – xanthomas.[aoporphan.com]

  • Familial Hyperlipidemia

    His physical exam is normal and there is no tendon xanthomas or corneal arcus. Familial hypercholesterolemia (FH) is suspected.[knowledge.statpearls.com] […] clearance of LDL; increased production of VLDL Increased levels of LDL and VLDL Increased cholesterol and TGs Increased risk of atherosclerosis and coronary disease Familial[quizlet.com] Image of tendon xanthoma, a pathognomonic physical examination finding in patients with familial hypercholesterolemia. Figure.[jaoa.org]

  • Hyperlipoproteinemia Type 4

    Clinical findings: Tendon xanthomas, Xanthelasma, premature coronary artery disease and stroke.[medicowesome.com] LDL, decreased HDL, increased triglycerides Alcohol excess Increased triglycerides, increased HDL Cholestasis Increased LDL, increased total chol Diabetes Mellitus Hyperlipidaemia[diapedia.org] Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org]

  • Hyperlipoproteinemia Type 2b

    tendon xanthomas, most often on the hands and feet Patients with combined hypercholesterolemia andhypertriglyceridemia, have what kind of xanthoas?[brainscape.com] From More Specific Terms familial combined hyperlipidemia Etiology familial form ( familial combined hyperlipidemia ) defect in LDL receptor Laboratory increase in LDL cholesterol[anvita.info] Type 1- hyperchylomicronemia- increased chylomicrons due to lipoprotien lipase defficiency Type 2a- Hypercholesterolemia- increased LDL due to decreased LDL receptors Type[usmleforum.com]

  • Hyperlipidemia Type 5

    Simon-Broome and Dutch criteria utilize lipid profiles, history of premature CVD, and physical examination findings such as tendon xanthomas from both the patient and family[acc.org] No increased risk of heart disease. Tx: Low fat diet Type 2A - Hypercholesterolemia Deficiency in LDL Receptors. Increased risk Ischemic Heart Disease.[quizlet.com] […] concentration Increased circulating LDL level Increased LDL cholesterol [ more ] 0003141 30%-79% of people have these symptoms Corneal arcus 0001084 Diabetes mellitus 0000819[rarediseases.info.nih.gov]

  • Coronary Atherosclerosis

    These mutations cause a decreased number of LDLR, elevated levels of serum total and LDL cholesterol, and phenotypes of tendon xanthomas, premature CAD, MI and stroke.[doi.org] Increased LDL levels were observed over time in patients with the -7673G A polymorphism of the ApoB gene.[ncbi.nlm.nih.gov] Xanthoma are sharply demarcated yellowish collection of cholesterol under the skin, that can occur anywhere on the body, but are most often seen on the elbows, joints, tendons[clinicaladvisor.com]

  • Cholesterol Ester Storage Disease

    Tendon xanthomas may cause discomfort and interfere with tendon flexibility.[icdlist.com] This explains the laboratory results detailed above: permanent hypercholesterolemia, increased LDL cholesterol and decreased HDL cholesterol.[symptoma.com] This results in an increase in the number and activity of LDL receptors on the hepatocyte membrane, and the rate of LDL catabolism increases.[lipidworld.biomedcentral.com]

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