Alzheimer disease is the most common form of dementia. The etiology of AD remains, in large part, unresolved, however, RORA (Retinoic Acid Receptor-related Orphan Receptor) emerges as a gene with a probable central role in the AD pathology/etiology. The main reversible causes of dementia include vitamin B12…
About 70% of patients have minor developmental and learning disabilities. […] These co-morbidities include increased risk for diabetes, cardiovascular events, and osteoporosis, as well as developmental delays, mild retardation, learning disabilities […] Complications of Klinefelter syndrome include osteoporosis, increased cardiovascular risk, mild to moderate developmental and learning disabilities, and increased psychosocial
Up to half of affected individuals have intellectual disability that ranges from mild to severe, and those with normal intelligence may have learning disabilities.
Associated mental health problems include: depression, anxiety disorder, and learning disabilities. […] Learning disabilities can include developmental speech and language disorders and academic skills disorders. […] ADHD, however, is not considered a learning disability, but it very frequently causes academic difficulties.
Prior to this, the diagnosis of TSC was largely restricted to severely affected individuals with Vogt's triad of learning disability, seizures, and facial angiofibroma. […] The prognosis for individuals with TSC depends on the severity of symptoms, which range from mild skin abnormalities to varying degrees of learning disabilities and epilepsy
Curfs and Fryns (1992) conducted research into the varying degrees of learning disability found in PWS.
A standard 30-cell karyotype analysis is required for diagnosis of Turner syndrome, in order to exclude mosaicism. Patients with Turner syndrome should be investigated for the presence of Y chromosomal material using a Y-centromeric probe. Malignant gonadoblastomas or testicular tissue might be seen in these…
Although the diagnosis can't be made solely on physical signs, a clinical suspicion toward this condition should be made in patients where other causes have been excluded, such as lymphomas and leukemias, as well as other lysosomal storage diseases that have a similar clinical presentation. Workup starts with a…