Left Shift of WBC: Causes & Reasons

Possible Causes for Left Shift of WBC

What is Pseudomonas aeruginosa? Pseudomonas aeruginosa is a Gram-negative, rod-shaped bacterium. P. aeruginosa is a ubiquitous microorganism, which means it has the ability to survive under a variety of environmental conditions. It is commonly found in the environment e.g. water and soil. It causes disease in plants,[…] [nicd.ac.za]

Septicemia

Objective: In patients receiving inappropriate empirical antimicrobial agents, delaying of time to report positive hemoculture (TRH) may cause delay switching from inappropriate antimicrobial agents to appropriate antimicrobial agents, and thus may increase mortality. We hypothesized that the patients with septicemia[…] [ncbi.nlm.nih.gov]

Primary Myelofibrosis

Abstract Bone marrow fibrosis (BMF) is a histologic finding in a wide range of diseases, including malignancies, endocrine disorders, autoimmune diseases, and infections. Autoimmune myelofibrosis (AIMF) is an uncommon etiology of BMF; it can be secondary to a defined autoimmune disease, or it can be primary in the[…] [ncbi.nlm.nih.gov]

Familial Myelofibrosis

Familial myelofibrosis (FM) is a rare variant of primary myelofibrosis. It is a myeloproliferative disorder caused by germline mutations affecting the maturation, differentiation, and function of hematopoietic stem cells. As a consequence of excess release of certain growth factors, hematopoietic tissue is progressively[…] [symptoma.com]

Q Fever

What is Q-Fever? Query or Queensland fever (Q fever) is a bacterial infection affecting a variety of animal species as well as human beings. Q fever is caused by Coxiella burnetii, an obligate, intracellular, rickettsial organism that can survive in a dried condition for extended periods. Is Q-Fever widespread? Coxiella[…] [waddl.vetmed.wsu.edu]

Tularemia

Pictures of tularemia and disease information have been excerpted from VisualDx clinical decision support system as a public health service. Additional information, including symptoms, diagnostic pearls, differential diagnosis, best tests, and management pearls, is available in VisualDx. How VisualDx Works Media Kit[…] [visualdx.com]

Hemophilus Parainfluenzae Infection

Review. 2021 Nov;22(9):940-947. doi: 10.1089/sur.2020.172. Epub 2021 May 7. Affiliations PMID: 33970041 DOI: 10.1089/sur.2020.172 Review A Series of Haemophilus parainfluenzae Surgical Infections and Review of the Literature Oluwatobi O Onafowokan et al. Surg Infect (Larchmt). 2021 Nov. Abstract Background: Haemophilus[…] [pubmed.ncbi.nlm.nih.gov]

Systemic Inflammatory Response Syndrome

Please log in to edit this article. Edit Synonym: Systemic inflammatory response syndrome German : SIRS 1 Definition SIRS is the acronym for " S ystemic I nflammatory R esponse S yndrome". This is a disease pattern that is similar to a sepsis, without (in contrast to that) a detectable infection. 2 Etiology Possible[…] [flexikon.doccheck.com]

Listerial Sepsis

Meta-Analysis. 2022 Feb;19(2):104-114. doi: 10.1089/fpd.2021.0046. Epub 2021 Dec 9. Affiliations PMID: 34883025 DOI: 10.1089/fpd.2021.0046 Meta-Analysis Septicemia Due to Listeria monocytogenes Infection: A Systematic Review and Meta-Analysis Kenzie Schaefer et al. Foodborne Pathog Dis. 2022 Feb. Abstract Listeriosis is a[…] [pubmed.ncbi.nlm.nih.gov]

Aortic Angiosarcoma

Admission laboratory evaluation revealed leukocytosis (WBC 23 X 109/L) with a left shift, elevated c-reactive protein (72 mg/L) and elevated erythrocyte sedimentation rate [meeting.savs.org]

Splenitis

Blood analysis revealed a moderate neutrophilia (43,000 WBC) with a left shift. Blood chemistry was normal. [sonopath.com]

Hereditary Neutrophilia

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

shift, toxic changes, increased LAP score Term Hematologic features for Leukemoid reaction Definition neutrophilic reaction, WBC count > 50 x 103/uL, left shift with immature [flashcardmachine.com]

The release of less-mature bands and metamyelocytes into the peripheral circulation results in the so-called “left shift” in the WBC differential. [aafp.org]

Leukoerythroblastic Anemia

↑, left shifted, basophilia, eosinophilia, rarely monocytosis Normal or ↑, +/- basophils, (leukoerythroblastic ini fibrotic stage) ↑granulocytes if leukoerythroblastic Normal [surgpathcriteria.stanford.edu]

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

Peripheral Blood CML PV Cellular Phase PMF ET RBC Normal or ↓ Normal, ↑ or ↓, may be hypochromatic or polychromatic ↓, teardrop cells Normal or ↓ (iron deficient anemia) WBC [surgpathcriteria.stanford.edu]

Leukemoid Reaction

This is known as a 'left shift'. A very high WBC count (>50,000) with pronounced left shift that is not a leukemia is known as a "leukemoid reaction". [library.med.utah.edu]

In this particular case, leukocytosis represented a true leukemoid reaction as suggested by the elevated LAP and lack of a left shift on the WBC differential. [pancreas.imedpub.com]

After paclitaxel injection, the WBC count increased to 70.37*109/L. Bone marrow aspirates and biopsy showed left-shift neutrophilia, which confirmed leukemoid reaction. [ncbi.nlm.nih.gov]

Perforated Appendix

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

Also in the study, WBC was found elevated in 63% of all patients with 74% shifts to left. [wjes.biomedcentral.com]

left shift of WBCs, ↑ ESR Diagnosis Hx, PE, ultrasound, CT Management Appendectomy Complications Rupture, purulent peritonitis; untreated, death. [medical-dictionary.thefreedictionary.com]

Pelvic Appendix

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

CBC: increased WBC (>10,000 in >90% of cases), most often with a "left shift" (bandemia) Urinalysis: to evaluate for pyelonephritis or renal calculus Can you have an abnormal [quizlet.com]

[…] of WBCs to the left 1 Total 10 Source: Alvarado. [18] RLQ = right lower quadrant; WBCs = white blood cells Clinical scoring systems are attractive because of their simplicity [emedicine.medscape.com]

Atypical Chronic Myeloid Leukemia

Left shifted neutrophilia* Left shifted neutrophilia Monocytosis, may have left shifted neutrophilia Neutrophilia B lood basophils Increased Not increased Not increased Not [surgpathcriteria.stanford.edu]

Myeloproliferative and Mixed MDS/MPNs with Neutrophilia and/or Monocytosis CML -CP Atypical CML CMML-1 CNL Ph Chromosome and/or BCR-ABL1 Translocation Almost 100% Absent Absent Absent WBC [surgpathcriteria.stanford.edu]

Normocytic Normochromic Anemia

shift of WBCs Leukocytosis Thrombocytosis Blood loss, chronic Same as iron deficiency Same as iron deficiency Folate deficiency Same as vitamin B12 deficiency Serum folate [merckmanuals.com]

Common Anemias Etiology or Type Morphologic Changes Special Features Blood loss, acute Normochromic-normocytic, with polychromatophilia If severe, possible nucleated RBCs and left [merckmanuals.com]

Pituitary-Snuff-Taker's Lung

[…] with left shift (gram positive) -Red to gray hepatization; heavy -edema and WBC's in alveoli Nosocomial > community acquired (superinfection with flu; CF) Forms abscesses [quizlet.com]

[…] of infection in both lungs -onset tends to be insidious -purulent sputum (yellow or green) -normal or impaired defenses -sx: cough, fever, rusty sputum -Lobar -elevated WBC [quizlet.com]

Perforated Diverticulum

[…] hypogastrium, pain of variable severity may radiate to the back, rebound tenderness, fever, anorexia, constipation, GI tract discomfort, N&V Lab ↑ WBCs, left shift of myeloid [medical-dictionary.thefreedictionary.com]

Laboratory values are unremarkable except for a WBC count of 12,500 with a left shift. [medbullets.com]

Surgery Inflammation of one or more diverticula which, when acute, may rupture causing peritonitis Clinical More common in the elderly; ± abrupt onset with tenderness in left [medical-dictionary.thefreedictionary.com]

Pelvic Cancer

[…] to improve) Perinephric abscess – symptoms usually persist >5 days: Sx: Fever, flank pain, dysuria Labs: Leukocytosis with left shift, positive urinalysis (+ nitrites, + [cancertherapyadvisor.com]

shift, positive urinalysis (+ nitrites, + leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast (after 72 hours if failure [cancertherapyadvisor.com]

[…] leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast – modality of choice Nephrolithiasis: Sx: Colicky flank pain, nausea [cancertherapyadvisor.com]

Pericardial Disorder

On the first day of her life, she had WBC = 36,000 with a left shift and 27% blasts, without organomegaly, consistent with Children's Oncology Group (COG) “low risk” TMD, [clincancerres.aacrjournals.org]

Appendicitis

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

Based on this, we hypothesized that IG% may be beneficial for detecting appendicitis, in addition to classic inflammatory markers including the WBC count, a left shift in [ncbi.nlm.nih.gov]

Radiography/Labs: A CBC may initially show a normal leukocyte count but will eventually progress to leukocytosis with a left shift. [sages.org]

Acute Pelvic Cellulitis

shift, positive urinalysis (+ nitrites, + leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast (after 72 hours if failure [clinicaladvisor.com]

Immune Complex-Mediated Small Vessel Vasculitis

shift ↑ White blood cell ( WBC ) count ↓ Hemoglobin Coagulation profile: usually normal Serum antibodies and complement: ↑ IgA in serum Evidence of circulating IgA immune [amboss.com]

Laboratory tests Indications : useful in patients with an incomplete or unusual presentation Complete blood cell count with differential: ↑ Platelet count Eosinophilia, left [amboss.com]

Chronic Appendicitis

An elevated WBC count or left shift are helpful markers for the diagnosis of appendicitis in children with nontraumatic acute abdominal pain. 3 The diagnostic accuracy of [mhmedical.com]

[…] the WBC is better than C-reactive protein (CRP), but even when both are normal, there is a small chance (between 0% and 5%) that appendicitis is present. 4 An abdominal x-ray [mhmedical.com]

Chronic Neutrophilic Leukemia

Chronic Phase of Chronic Myeloid Leukemia

Neutrophilia (a left-shifted WBC differential), basophilia, and eosinophilia are common. The platelet count is normal or moderately increased. [merckmanuals.com]

Syphilitic Arthritis

>10K with left shift ESR >30 ESR is often elevated but may be normal early in process rises within 2 days of infection and can rise 3-5 days after initiation of appropriate [orthobullets.com]

[…] such as hip can be used in guiding aspirations MRI indications detects joint effusion, and may detect adjacent bone involvement such as osteomyelitis Studies Serum labs WBC [orthobullets.com]

Gaisbock Syndrome

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

[…] usually < 20k/L) with rare left shift Mild basophilia may be seen Thrombocytosis; may be particularly prominent in prodromal phase or exaggerated by concurrent iron deficiency [pathologyoutlines.com]

Hypersegmented neutrophils - see Right shift below. [patient.info]