Left Shift of WBC: Causes & Reasons

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Possible Causes for Left Shift of WBC

Pseudomonas Aeruginosa

Pseudomonas aeruginosa sepsis usually carries a high mortality rate in immunocompromised children. Ecthyma gangrenosum is a known cutaneous manifestation due mainly to Pseudomonas infection with or without septicemia. We describe clinical, biological, and therapeutic data. Of those children admitted to the pediatric[…] [ncbi.nlm.nih.gov]

Septicemia

Septicemia due to Pasteurella (Mannheimia) haemolytica is a rare occurrence. We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. Rare cases of systemic Mannheimia[…] [ncbi.nlm.nih.gov]

Primary Myelofibrosis

Primary myelofibrosis (PMF) is a clonal hematopoietic stem cell disorder. It is characterized by bone marrow fibrosis, extramedullary hematopoiesis with hepatosplenomegaly and leukoerythroblastosis in the peripheral blood. The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[…] [ncbi.nlm.nih.gov]

Familial Myelofibrosis

Familial myelofibrosis (FM) is a rare variant of primary myelofibrosis. It is a myeloproliferative disorder caused by germline mutations affecting the maturation, differentiation, and function of hematopoietic stem cells. As a consequence of excess release of certain growth factors, hematopoietic tissue is progressively[…] [symptoma.com]

Q Fever

Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and other animals. This organism is uncommon, but may be found in cattle, sheep, goats, and other domestic mammals, including cats and dogs. The infection results from inhalation of a spore-like small-cell variant, and from[…] [en.wikipedia.org]

Tularemia

Tularemia Other names Tularaemia, Pahvant Valley plague,[1] rabbit fever,[1] deer fly fever, Ohara's fever[2] A tularemia lesion on the back of the right hand Specialty Infectious disease Symptoms Fever, skin ulcer, large lymph nodes[3] Causes Francisella tularensis (spread by ticks, deer flies, contact with infected[…] [en.wikipedia.org]

Hemophilus Parainfluenzae Infection

« Previous Article Table of Contents Next Article » Abstract Fulltext Figs (0) References (18) Cited By (1) Supplementary Material (0) Metrics Related Content Preview this: Post-operative wound and vascular graft infection caused by Haemophilus parainfluenzae, Page 1 of 1 < Previous page | Next page >[…] [jmmcr.microbiologyresearch.org]

Systemic Inflammatory Response Syndrome

Please log in to edit this article. Edit Synonym: Systemic inflammatory response syndrome German : SIRS 1 Definition SIRS is the acronym for " S ystemic I nflammatory R esponse S yndrome". This is a disease pattern that is similar to a sepsis, without (in contrast to that) a detectable infection. 2 Etiology Possible[…] [flexikon.doccheck.com]

Listerial Sepsis

Referencias bibliográficas 1.- Murray E G D, Webb R A, Swann M B R. A disease of rabbits characterized by a large mononuclear leucocytosis, caused by a hitherto undescribed bacillus: Bacterium monocytogenes (n.sp.). J Pathol Bacteriol 1926; 29: 407-39. [ Links ] 2.- Lee J, Kyoung W, Hee Nam Ch, Ho Jung M, Han Kang[…] [scielo.conicyt.cl]

Splenitis

Blood analysis revealed a moderate neutrophilia (43,000 WBC) with a left shift. Blood chemistry was normal. [sonopath.com]

Perforated Appendix

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

Also in the study, WBC was found elevated in 63% of all patients with 74% shifts to left. [wjes.biomedcentral.com]

left shift of WBCs, ↑ ESR Diagnosis Hx, PE, ultrasound, CT Management Appendectomy Complications Rupture, purulent peritonitis; untreated, death. [medical-dictionary.thefreedictionary.com]

Hereditary Neutrophilia

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

shift, toxic changes, increased LAP score Term Hematologic features for Leukemoid reaction Definition neutrophilic reaction, WBC count > 50 x 103/uL, left shift with immature [flashcardmachine.com]

The release of less-mature bands and metamyelocytes into the peripheral circulation results in the so-called “left shift” in the WBC differential. [aafp.org]

Leukoerythroblastic Anemia

↑, left shifted, basophilia, eosinophilia, rarely monocytosis Normal or ↑, +/- basophils, (leukoerythroblastic ini fibrotic stage) ↑granulocytes if leukoerythroblastic Normal [surgpathcriteria.stanford.edu]

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

Peripheral Blood CML PV Cellular Phase PMF ET RBC Normal or ↓ Normal, ↑ or ↓, may be hypochromatic or polychromatic ↓, teardrop cells Normal or ↓ (iron deficient anemia) WBC [surgpathcriteria.stanford.edu]

Leukemoid Reaction

This is known as a 'left shift'. A very high WBC count (>50,000) with pronounced left shift that is not a leukemia is known as a "leukemoid reaction". [library.med.utah.edu]

In this particular case, leukocytosis represented a true leukemoid reaction as suggested by the elevated LAP and lack of a left shift on the WBC differential. [pancreas.imedpub.com]

After paclitaxel injection, the WBC count increased to 70.37*109/L. Bone marrow aspirates and biopsy showed left-shift neutrophilia, which confirmed leukemoid reaction. [ncbi.nlm.nih.gov]

Pelvic Appendix

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

CBC: increased WBC (>10,000 in >90% of cases), most often with a "left shift" (bandemia) Urinalysis: to evaluate for pyelonephritis or renal calculus Can you have an abnormal [quizlet.com]

[…] of WBCs to the left 1 Total 10 Source: Alvarado. [18] RLQ = right lower quadrant; WBCs = white blood cells Clinical scoring systems are attractive because of their simplicity [emedicine.medscape.com]

Normocytic Normochromic Anemia

shift of WBCs Leukocytosis Thrombocytosis Blood loss, chronic Same as iron deficiency Same as iron deficiency Folate deficiency Same as vitamin B12 deficiency Serum folate [merckmanuals.com]

Common Anemias Etiology or Type Morphologic Changes Special Features Blood loss, acute Normochromic-normocytic, with polychromatophilia If severe, possible nucleated RBCs and left [merckmanuals.com]

Atypical Chronic Myeloid Leukemia

Left shifted neutrophilia* Left shifted neutrophilia Monocytosis, may have left shifted neutrophilia Neutrophilia B lood basophils Increased Not increased Not increased Not [surgpathcriteria.stanford.edu]

Myeloproliferative and Mixed MDS/MPNs with Neutrophilia and/or Monocytosis CML -CP Atypical CML CMML-1 CNL Ph Chromosome and/or BCR-ABL1 Translocation Almost 100% Absent Absent Absent WBC [surgpathcriteria.stanford.edu]

Pituitary-Snuff-Taker's Lung

[…] with left shift (gram positive) -Red to gray hepatization; heavy -edema and WBC's in alveoli Nosocomial > community acquired (superinfection with flu; CF) Forms abscesses [quizlet.com]

[…] of infection in both lungs -onset tends to be insidious -purulent sputum (yellow or green) -normal or impaired defenses -sx: cough, fever, rusty sputum -Lobar -elevated WBC [quizlet.com]

Appendicitis

Lab Increased WBCs, left shift of WBCs, increased ESR. Diagnosis History, physical exam, ultrasound, CT. Management Appendectomy. [medical-dictionary.thefreedictionary.com]

Based on this, we hypothesized that IG% may be beneficial for detecting appendicitis, in addition to classic inflammatory markers including the WBC count, a left shift in [ncbi.nlm.nih.gov]

Radiography/Labs: A CBC may initially show a normal leukocyte count but will eventually progress to leukocytosis with a left shift. [sages.org]

Perforated Diverticulum

[…] hypogastrium, pain of variable severity may radiate to the back, rebound tenderness, fever, anorexia, constipation, GI tract discomfort, N&V Lab ↑ WBCs, left shift of myeloid [medical-dictionary.thefreedictionary.com]

Laboratory values are unremarkable except for a WBC count of 12,500 with a left shift. [medbullets.com]

Surgery Inflammation of one or more diverticula which, when acute, may rupture causing peritonitis Clinical More common in the elderly; ± abrupt onset with tenderness in left [medical-dictionary.thefreedictionary.com]

Pelvic Cancer

[…] to improve) Perinephric abscess – symptoms usually persist >5 days: Sx: Fever, flank pain, dysuria Labs: Leukocytosis with left shift, positive urinalysis (+ nitrites, + [cancertherapyadvisor.com]

shift, positive urinalysis (+ nitrites, + leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast (after 72 hours if failure [cancertherapyadvisor.com]

[…] leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast – modality of choice Nephrolithiasis: Sx: Colicky flank pain, nausea [cancertherapyadvisor.com]

Chronic Appendicitis

An elevated WBC count or left shift are helpful markers for the diagnosis of appendicitis in children with nontraumatic acute abdominal pain. 3 The diagnostic accuracy of [mhmedical.com]

[…] the WBC is better than C-reactive protein (CRP), but even when both are normal, there is a small chance (between 0% and 5%) that appendicitis is present. 4 An abdominal x-ray [mhmedical.com]

Immune Complex-Mediated Small Vessel Vasculitis

shift ↑ White blood cell ( WBC ) count ↓ Hemoglobin Coagulation profile: usually normal Serum antibodies and complement: ↑ IgA in serum Evidence of circulating IgA immune [amboss.com]

Laboratory tests Indications : useful in patients with an incomplete or unusual presentation Complete blood cell count with differential: ↑ Platelet count Eosinophilia, left [amboss.com]

Acute Pelvic Cellulitis

shift, positive urinalysis (+ nitrites, + leukocyte esterase, WBC casts) and urine culture, blood cultures Imaging: Abdominal CT with IV contrast (after 72 hours if failure [clinicaladvisor.com]

Pericardial Disorder

On the first day of her life, she had WBC = 36,000 with a left shift and 27% blasts, without organomegaly, consistent with Children's Oncology Group (COG) “low risk” TMD, [clincancerres.aacrjournals.org]

Chronic Neutrophilic Leukemia

Ureteral Carcinoma

Because of clinical findings of fever, a left shift of WBCs, and elevation of C-reactive protein level, the condition of one of our patients ( Fig. 6 ) was diagnosed as a [ajronline.org]

Chronic Phase of Chronic Myeloid Leukemia

Neutrophilia (a left-shifted WBC differential), basophilia, and eosinophilia are common. The platelet count is normal or moderately increased. [merckmanuals.com]

Gaisbock Syndrome

Left shift describes immature WBCs that are released from the marrow when there is a cause of marrow outpouring, typically due to infection. [patient.info]

[…] usually < 20k/L) with rare left shift Mild basophilia may be seen Thrombocytosis; may be particularly prominent in prodromal phase or exaggerated by concurrent iron deficiency [pathologyoutlines.com]

Hypersegmented neutrophils - see Right shift below. [patient.info]

Syphilitic Arthritis

>10K with left shift ESR >30 ESR is often elevated but may be normal early in process rises within 2 days of infection and can rise 3-5 days after initiation of appropriate [orthobullets.com]

[…] such as hip can be used in guiding aspirations MRI indications detects joint effusion, and may detect adjacent bone involvement such as osteomyelitis Studies Serum labs WBC [orthobullets.com]