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133 Possible Causes for Leg Cramp, Proximal Muscle Weakness of the Lower Extremity

  • Graves Disease

    Graves' disease is the most common cause of hyperthyroidism and is often managed with radioactive iodine (RAI) therapy. With current dosing schemes, the vast majority of patients develop permanent post-RAI hypothyroidism and are placed on life-long levothyroxine therapy. This hypothyroidism typically occurs within[…][ncbi.nlm.nih.gov]

  • Oculopharyngeal Muscular Dystrophy

    Muscle weakness occurs mostly in your arms and legs, with symptoms appearing between age 11 and 25.[healthline.com] The proband first noticed bilateral ptosis, dysphagia, and proximal dominant muscle weakness in the lower extremities at age 53.[ncbi.nlm.nih.gov] Other signs that occur as the disease progresses include tongue weakness and atrophy, proximal upper and lower extremity weakness, dysphonia, dysarthria, facial muscle weakness[orpha.net]

  • Spinal Stenosis

    […] bending over Burning, tingling, numbness in your lower back, buttocks, and legs Cramping in your legs after standing or walking for long periods Bladder or bowel issues ([braceability.com] […] while walking or standing Cramping sensation in these areas Decreased walking due to weakness, numbness or pain in legs Cervical Stenosis Arthritic changes in neck Bone spurs[spineorthocenter.com] Symptoms: Leg (neurogenic Intermittent Claudication) Characteristics Leg Fatigue (dullness) or Leg Weakness Leg numbness or Paresthesia s (tingling sensation) Bilateral Leg[fpnotebook.com]

  • Lumbar Disk Herniation

    Symptoms of a herniated disc may include dull or sharp pain, muscle spasm or cramping, sciatica , and leg weakness or loss of leg function.[spineuniverse.com] Symptoms of a herniated disc may include dull or sharp pain, muscle spasm or cramping, sciatica, and leg weakness or loss of leg function.[spineuniverse.com] Sometimes the pain is accompanied by numbness and tingling in your leg or foot. You may experience cramping or muscle spasms in your back or leg.[mayfieldclinic.com]

  • Limb-Girdle Muscular Dystrophy

    […] or Arms; Proximal Cramps: Legs Cataracts (50%) Weakness Proximal Distal Legs 100%; Arms 90% Finger & Toe flexion: Limited Muscle atrophy Contractures : Limited flexion of[neuromuscular.wustl.edu] The proband displayed major weakness in lower extremities that progressed and affected the upper proximal shoulder and girdle muscles.[humgenomics.biomedcentral.com] Muscular weakness was stable until the age of 21, afterward, progressive weakening of the muscles of the proximal regions of the lower extremities began.[frontiersin.org]

  • Secondary Hyperparathyroidism

    Vitamin D deficiency results in abnormal mineralization of the bone, which manifests as bowed legs or knocked knees in children.[symptoma.com] Physical examination on admission revealed a blood pressure of 155/89 mmHg, pulse rate of 81/min, and severe flaccid weakness of the proximal muscles of all four limbs, with[edmcasereports.com] […] with severe cases of hypocalcemia and vitamin D deficiency will suffer from neuromuscular symptoms, including paresthaesia in the fingers, toes, or around the mouth; muscle cramps[symptoma.com]

  • Autosomal Dominant Spastic Paraplegia Type 41

    These symptoms can include: Leg cramps Paresthesia Muscle spasms Highly arched feet Bladder control problems Relatively mild muscle wasting Diminished vibration sense in the[disabled-world.com] muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise.[orpha.net] […] and leg weakness. [31] Also reported was that muscle strength and function correlated directly with serum testosterone levels.[emedicine.medscape.com]

  • Acute Hepatic Porphyria

    Less often, abdominal pain is described as cramping. Pain may also occur in the neck, lower back, buttocks, or arms and legs.[rarediseases.org]

  • Acute Intermittent Porphyria

    Less often, abdominal pain is described as cramping. Pain may also occur in the neck, lower back, buttocks, or arms and legs.[rarediseases.org]

  • Amyloidosis

    Itching, skin rash, diarrhea or constipation, muscle cramps and backache, leg swelling, risk of blood clot in veins, low platelets in blood.[ahajournals.org]

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