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66 Possible Causes for Leg Pain, Leukopenia, Massive Splenomegaly

  • Gaucher Disease

    Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.[] CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[] “We were playing tennis,” she recalled, when she felt what was like “drills going through my legs and hips—I fell down.”[]

  • Primary Myelofibrosis

    We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia[] Abstract Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary[] […] or discomfort pain in the left shoulder or upper left portion of the body unexpected bleeding bone pain, especially in the legs Diagnosis Because symptoms are similar to[]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[] , or swollen area Arm or leg: Sore, warm, and swollen limb Stomach : Pain Ulcers and bleeding Brain : Bad headache with or without vomiting Seizures Trouble moving, talking[]

  • Felty's Syndrome

    Splenectomy may be considered in those with massive splenomegaly or recurrent infections.[] Stiff, swollen, or painful joints, usually in your hands, feet, or arms You also will have a swollen spleen -- a fist-sized organ behind your left ribs.[] Jump to navigation Jump to search syndrome that results in rheumatoid arthritis, splenomegaly and neutropenia Felty syndrome Rheumatoid arthritis with splenoadenomegaly and leukopenia[]

  • Hypersplenism

    Unfortunately, these patients may become intolerant to this therapy when it is complicated by hypersplenism with leukopenia and/or thrombocytopenia.[] CONCLUSION: Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe[] .  Clinical features • Anemia • Pain abdomen • Leg ulcers • Cerebral pulmonary and mesenteric infracts  Diagnosis by electrophoresis  Treatment • Sodium cyanate • Partial[]

  • Myeloproliferative Disease

    Painful swollen joints, caused by gouty arthritis , which is in turn caused by hyperuricemia Bone pain Priapism Tinnitus Stupor due to leukostasis Left upper quadrant and[] WBC are increased and there is increased thrombocytosis Later phases: increasing and progressive fibrosis in BM, splenomegaly/hepatomegaly, moderate to marked anemia, leukopenia[] Painful swollen joints, caused by gouty arthritis, which is in turn caused by hyperuricemia Bone pain Priapism Tinnitus Stupor due to leukostasis Left upper quadrant and[]

  • Leukemia

    Case Study A 6-year-old boy who has Down syndrome presents with a 2-day history of fever (temperature to 39.0 C) and a painful limp and favoring of his right leg.[] Common side effects of Besponsa include low levels of platelets (thrombocytopenia), low levels of certain white blood cells (neutropenia, leukopenia), infection, low levels[] He had been having a pain in his left leg for 20 days before that. There were no other symptoms. The next day after his birthday, he started developing a fever .[]

  • Post-Polycythemia Vera Myelofibrosis

    Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[] Our present case suggests the potential risk of TLS development after ruxolitinib treatment, particularly in patients with massive splenomegaly.[] Thrombosis may cause symptoms in the affected site (leg pain, swelling or both with lower extremity thrombosis, unilateral vision loss with retinal vascular occlusion).[]

  • Agranulocytosis

    This time she was febrile, extremely intoxicated with general lymphadenopathy, catarrhal gingivostomatitis and massive splenomegaly.[] […] gums and lesions on ears, arms, legs, and trunk Powder/Snort 0 24 5/2/08 5 Not done Full recovery 10 Colorado 40s Female Unknown Arm and neck mass with fever and cough.[] Abstract The risks of severe leukopenia and agranulocytosis have varied over time and among geographical regions and cultures, with little information available on South American[]

  • Lymphoma

    […] lymphocytic leukemia [SLL/CLL]) Bleeding secondary to thrombocytopenia, disseminated intravascular coagulation (DIC), or vascular invasion by the tumor Infection secondary to leukopenia[] T-cell CLL usually is a more aggressive disorder than B-cell CLL, with massive splenomegaly, marked neutropenia, skin infiltration, modest bone marrow infiltration, and a[] Presenting symptoms in all 4 patients included back pain, radicular leg pain, and leg weakness, similar to spondylotic radiculopathy.[]

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