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509 Possible Causes for Leg Swelling, Protein C Deficiency

  • Hereditary Deficiency of Antithrombin

    Blood clots in the arms or legs usually cause swelling, redness, and pain.[medlineplus.gov] The incidence of thromboembolism in 48 females heterozygous for hereditary type I deficiency of antithrombin III (n 15), protein C (n 16) or protein S (n 17), who had taken[ncbi.nlm.nih.gov] Symptoms Patients will usually have symptoms of a blood clot, including: Coughing up blood Fainting Shortness of breath and pain when taking deep breaths Swelling of one leg[coordinatedhealth.com]

  • Deep Vein Thrombosis

    His left leg was hugely swelled. He had normal leg hair distribution.[ncbi.nlm.nih.gov] : The current study aims to explore the phenotype and genotype of a mutation Ala291Thr, which responsible for type I protein C (PC) deficiency in a Chinese woman.[ncbi.nlm.nih.gov] Kaufman: DVT is more common as we age and in patients with inherited blood clotting disorders, such as Protein C Deficiency, cancer and women who are on birth control pills[sheknows.com]

  • Thrombosis

    This condition is characterized by pooling of blood, chronic leg swelling, increased pressure, increased pigmentation or discoloration of the skin, and leg ulcers known as[my.clevelandclinic.org] After learning from a relative that some in the family had a Protein C Deficiency, a disorder that increases the risk of developing abnormal blood clots, Janet’s husband and[hopkinsallchildrens.org] Protein C deficiency or dysfunction -- Protein C helps regulate the speed of the coagulation cascade by degrading activated factors V and VIII.[web.archive.org]

  • Lymphedema

    Lymphedema is the swelling of a body part (usually arms or legs). This can occur after radiation or removal of lymph nodes.[allinahealth.org] The difference is when in life they first cause swelling of the legs or arms.[drugs.com] Lymphedema and any other type of leg swelling greatly increase the risk of infection in the skin and fatty tissues (cellulitis) of the extremity.[tennesseeveincare.com]

  • Vein Disorder

    Swelling of the leg is a further sign that damaged or diseased vein valves are not functioning properly.[cvvcenters.com] […] of natural anticoagulant (blood-thinning) proteins (antithrombin, protein C, protein S) Elevated blood counts Abnormal fibrinolysis (the breakdown of fibrin) Abnormal changes[webmd.com] Deficiency of natural anticoagulant (blood-thinning) proteins (antithrombin, protein C, protein S). Elevated blood counts.[medicinenet.com]

  • Liver Cirrhosis

    You may also get swelling in your legs, ankles or feet, known as peripheral oedema.[britishlivertrust.org.uk] Thrombin activation and microthrombosis of intrahepatic portal venules is a common feature in liver cirrhosis, due in part to relative protein C deficiency and altered coagulation-anticoagulation-fibrinolysis[ncbi.nlm.nih.gov] Plasma levels are also diminished in the presence of an acute thrombus. 8 Because a diagnosis of protein C, protein S and antithrombin deficiency is based on plasma level[dx.doi.org]

  • Stroke

    These include: preeclampsia (high blood pressure during pregnancy that can cause swelling in the hands, feet, and legs) premature rupture of the membranes (when a woman's[kidshealth.org] C deficiency, protein S deficiency, pregnancy) Sickle cell disease Fibromuscular dysplasia Arterial dissections Vasoconstriction associated with substance abuse (eg, cocaine[emedicine.com] Stroke in protein C deficiency. Am J Med. 1990 ; 89 :538–539. Crossref Medline Google Scholar 676.[doi.org]

  • May-Thurner Syndrome

    But providers should always rule out May-Thurner in a woman with unilateral swelling – typically in the left leg.[kansashealthsystem.com] S or Protein C deficiency or Anti-Thrombin III deficiency.[vascularcarecentre.com] S or Protein C deficiency, or Anti-Thrombin III deficiency.[tennesseeveincare.com]

  • Nephrotic Syndrome

    We report the case of a 23-year-old woman with a 2-week history of swelling around the eyes and both legs, and generalized body swelling.[ncbi.nlm.nih.gov] ., reduced antithrombin III levels, reduced protein C and S levels or activity) and impaired thrombolytic activity (decreased plasminogen levels, elevated plasminogen activator[jasn.asnjournals.org] Protein loss causes low protein count in the blood (hypoalbuminemia) and edemas (excess fluid in the interstitial cavity which is between the cells, causes leg swelling most[medical-dictionary.thefreedictionary.com]

  • Hemophilia

    Negrier C, Berruyer M, Durin A, Philippe N, Dechavanne M. Increased thrombin generation in a child with a combined factor IX and protein C deficiency.[nejm.org] Hemophilia C, also known as Rosenthal syndrome, is caused by low levels of factor XI (11), another blood protein required to make a blood clot.[ihtc.org] Hemophilia A and B are the best known types of hemophilia, but other clotting factor deficiencies also exist.[ihtc.org]

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