Paul McIntosh and Chafic Karam, Clinical Reasoning: A 38-year-old man with respiratory failure and progressive leg weakness, Neurology, 86, 18, (e190), (2016).
[dx.doi.org]
Proximal legs Weakness Proximal Legs > Arms Ptosis (40%) Course: Slow progression; Ambulation difficulties Vital capacity: 40% to 90% Cardiomyopathy (80%) Especially with
[neuromuscular.wustl.edu]
[…] after leg weakness Eventually occurs in 100% Diaphragm involvement: Common & Early; More symptomatic when supine Sleep disordered breathing: Common Expiration more involved
[neuromuscular.wustl.edu]