Systemic The patient may initially complain of abdominal pain, diarrhea or dysentery and fever. Blood tests may reveal eosinophilia. He may also complain of fatigue, lethargy and skin sores and itching. CNS Neurological involvement may present with headaches, nausea, paresthesia, seizures, signs of muscle weakness and…
Turcot syndrome is a rare hereditary disease marked by central nervous system tumors, colorectal polyps, and adenocarcinoma of the colon. Onset is usually during teenage years with nonspecific symptoms. The diagnosis depends on family history, clinical examination, and special tests like colonoscopy and imaging of…
Coeliac disease (celiac sprue, nontropical sprue, endemic sprue, gluten enteropathy) is a chronic autoimmune disorder of the small intestine that results in an inability to tolerate gliadin, a prolamin found in wheat. Symptoms include pain, chronic constipation, chronic diarrhoea, failure to thrive and fatigue.
Juvenile polyposis syndrome is a syndrome characterized by the appearance of multiple juvenile polyps in the gastrointestinal tract. Polyps are abnormal growths arising from a mucous membrane. These usually begin appearing before age 20, but the term juvenile refers to the type of polyp, not to the age of the…
Peutz-Jeghers syndrome is a genetic disorder with an autosomal dominant pattern of inheritance, characterized by the presence of multiple hamartomatous polyps in the gastrointestinal tract with distinguishable pigmented lesions in skin and mucous membranes.
The intestinal polyps may result in obstruction and…
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by generalized gastrointestinal polyps, alopecia, nail changes and hyperpigmentation.
In many cases, the symptoms appear in the following order: Gastrointestinal symptoms Weight loss Weakness Edema Ectodermal changes The ectodermal changes occur…
Congenital acquired immune deficiency syndrome occurs due to mother-to-child transmission of HIV in utero, during delivery or breast-feeding. Depending on various factors, around 5-50% of children born to HIV+ mothers are infected. The diagnosis is made by a combination of clinical and immunological criteria, while…
Small intestinal bacterial overgrowth is described as the accumulation of a large number of bacteria in this organ, which should not normally be located in the structure. There are often underlying diseases and factors associated with the development of this condition.
The clinical picture is variable. Some patients…